Frequency of ABO incompatibility as a cause of neonatal jaundice in neonatal unit of Ayub Teaching Hospital, Abbottabad

https://doi.org/10.53730/ijhs.v6nS8.14120

Authors

  • Adeela Ilyas Senior registrar paediatrics medicine, Muhammad teaching hospital
  • Inamullah Senior registrar paediatrics medicine, Muhammad teaching hospital
  • Iffat Mehmood Registrar, Paediatric Cardiology, Hayatabad Medical Complex
  • Sadia Jehanzeb Senior Registrar, Pediatrics medicine, Northwest teaching hospital
  • Naqib Jan Registrar, Paediatric cardiology, Hayatabad medical complex

Keywords:

frequency, ABO incompatibility, neonatal jaundice

Abstract

Background: Neonatal jaundice is a common problem encountered by neonatologists. After prevention of Rh-isoimmunization ABO incompatibility has become the most common cause of hemolysis. For infants delivered of 35 weeks gestation or later ABO incompatibility have been found to be the major risk factors for development of severe hyperbilirubinemia. Objective: To assess the frequency of ABO incompatibility as a cause of neonatal jaundice. Methodology: The current study was Cross-sectional descriptive study carried out at the Neonatal units of Ayub teaching hospital, Abbottabad. Study was carried out over a period of six months from 01-06-2011 to 30-11-2011. The calculated sample size based on using the WHO software was 246 patients. Investigations were done regarding mother and baby’s blood group, serum bilirubin levels (total, direct and indirect). Data was entered into computer using SPSS version 10. Results: A total of 246 neonates were included in this study. Mean age of the neonates was 4.62±4.09.  Males were 157 (63.8%) and females were 89 (36.2%). 

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References

Adhikari M, Mackenjee H. Care of the newborn. In: Wittenberg DF, editor. Coovadia’s paediatrics and child health. 6th ed. Cape Town, South Africa: Oxford University Press, 2010; p. 129–130.

Badlee Z Exchange transfusion in neonatal hyperbilirubinaemia: experience in Isfahan, Iran. Singapore Med J 2007; 48(5): 421-3

Brits H, Adendorff J, Huisamen D, Beukes D, Botha K, Herbst H, Joubert G. The prevalence of neonatal jaundice and risk factors in healthy term neonates at National District Hospital in Bloemfontein. African Journal of Primary Health Care and Family Medicine. 2018 May 3;10(1):1-6.

Brown SB, King RF. The mechanism of haem catabolism. Bilirubin formation in living rats by [18O]oxygen labelling. Biochem J. 1978;170(2):297–311. https://doi. org/10.1042/bj1700297

Ceelie, I., van der Starre, C., Tibboel, D., Stol, K., Koren, G., & de Wildt, S. N. (2011). Evaluation of drug formularies for pediatric intensive care. Pediatric Critical Care Medicine, 12(1), e14-e19.

Drabik-Clary K, Reddy VV, Benjamin WH, Boctor FN. Severe hemolytic disease of the newborn in a group B African-American infant delivered by a group O mother. Annals of Clinical & Laboratory Science. 2006 Mar 20;36(2):205-7.

Kalakheti BK, Singh R, Bhatta NK, Karki A, Baral N. Risk of neonatal hyperbilirubinemia in babies born to 'O' positive mothers: a prospective cohort study. Kathmandu Univ Med J (KUMJ). 2009 Jan-Mar;7(25):11-5. doi: 10.3126/kumj.v7i1.1758. PMID: 19483446.

Kaplan M, Hammerman C. Bilirubin and the Genome: The Hereditary Basis of Unconjugated Neonatal Hyperbilirubinemia. Curr Pharmacogen. 2005;3.

Kaplan M, Muraca M, Hammerman C, et al. Imbalance between production and conjugation of bilirubin: A fundamental concept in the mechanism of neonatal jaundice. Paediatrics. 2002;110(4):e47. https://doi.org/10.1542/peds.110.4.e47

Khan RS, Houlihan DD, Newsome PN. Investigating jaundice. Medicine. 2015;43(10):573–576. https://doi.org/10.1016/j.mpmed.2015.07.009

Kramer LI. Advancement of dermal icterus in the jaundiced newborn. Am J Dis Child. 1969;118(3):454–458.

Maisels MJ, Kring E. The contribution of hemolysis to early jaundice in normal newborns. Pediatrics. 2006;118(1):276–279. https://doi.org/10.1542/peds.2005- 3042

Maisels MJ, McDonagh AF. Phototherapy for neonatal jaundice. New England Journal of Medicine. 2008 Feb 28;358(9):920-8.

Marwaha N, Dhawan H, Thakral B, Kaur R, Basu S, Parmar V. Severe ABO hemolytic disease of newborn with a positive direct antiglobulin test. Indian journal of pathology & microbiology. 2009 Apr 1;52(2):292.

Moerschel SK, Cianciaruso LB, Tracy LR. A practical approach to neonatal jaundice. American family physician. 2008 May 1;77(9):1255-62.

Moyer VA, Ahn C, Sneed S. Accuracy of clinical judgment in neonatal jaundice. Arch Pediatr Adolesc Med. 2000;154(4):391–394. https://doi.org/10.1001/archpedi. 154.4.391

National Institute for Health and Care Excellence. Neonatal jaundice [homepage on the Internet]. Clinical guideline 98. London: Royal College of Obstetricians and Gynaecologists; 2010 [cited 2016 Jun 15]. Available from: https://www.nice.org. uk/guidance/cg98/evidence/full-guideline-pdf-245411821

Olusanya BO, Osibanjo FB, Slusher TM. Risk factors for severe neonatal hyperbilirubinemia in low and middle-income countries: A systematic review and meta-analysis. PLoS One. 2015;10(2):e0117229. https://doi.org/10.1371/journal. pone.0117229

Porter ML, Dennis BL. Hyperbilirubinemia in the term newborn. Am Fam Physician. 2002;65(4):599–606. https://doi.org/10.1001/archpedi.1969.02100040456007

Rennie J, Burman-Roy S, Murphy MS, Guideline Development Group. Neonatal jaundice: Summary of the NICE guidance. BMJ. 2010;340:c2409. https://doi.org/ 10.1136/bmj.c2409

Shaw E. A guide to the qualitative research process: evidence from a small firm study. Qualitative Market Research: An International Journal. 1999 Aug 1;2(2):59-70.

Worsley JB. Hyperbilirubinemia guidelines and unintended harms. Pediatrics. 2004 Oct;114(4):1134-5.

Published

02-04-2023

How to Cite

Ilyas, A., Inamullah, I., Mehmood, I., Jehanzeb, S., & Jan, N. (2023). Frequency of ABO incompatibility as a cause of neonatal jaundice in neonatal unit of Ayub Teaching Hospital, Abbottabad. International Journal of Health Sciences, 6(S8), 7016–7022. https://doi.org/10.53730/ijhs.v6nS8.14120

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Peer Review Articles