Oral alterations among children with congenital zika virus syndrome
A systematic review and meta-analysis
Keywords:
Children, Zika Virus, Congenital Zika Virus Syndrome, Oral Alterations, dental careAbstract
Background and aim: the aim of present study was evaluating the oral alterations in children with congenital Zika syndrome -associated microcephaly compared to the group of children without this problem. Method: all international databases, PubMed, Scopus, Science Direct, ISI, and Embase were examined, searching between 2015 to March 2023 based on keywords related to the objectives of the study. Stata/MP v.17 software was used to conduct the meta-analysis. Result: After reviewing the abstracts of 177 articles, 21 articles were selected for full text review, of which 5 articles were included in the meta-analysis. Odds ratio of delayed tooth eruption between children with congenital Zika syndrome group and control group was 1.79 (OR, 1.79 95% CI 1.33, 2.25; p<0.001). Children with congenital Zika syndrome -associated microcephaly, compared to healthy children, had 2.15 (OR, 2.15 95% CI 1.62, 2.67; p<0.001) times chance of palate alteration. Conclusion: chance of delay in deciduous dental eruption, difficulty in lip sealing, palate alteration and ankyloglossia in children with CZS-associated microcephaly was significantly more than the control group.
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Kazmi SS, Ali W, Bibi N, Nouroz F. A review on Zika virus outbreak, epidemiology, transmission and infection dynamics. Journal of Biological Research-Thessaloniki. 2020;27:1-11.
Bagul PD, Badar CN, Tiwari KJ. Zika Virus: A Review. Research Journal of Pharmacology and Pharmacodynamics. 2022;14(3):171-3.
Cao-Lormeau V-M, Blake A, Mons S, Lastère S, Roche C, Vanhomwegen J, et al. Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. The Lancet. 2016;387(10027):1531-9.
Bogoch II, Brady OJ, Kraemer MU, German M, Creatore MI, Kulkarni MA, et al. Anticipating the international spread of Zika virus from Brazil. The Lancet. 2016;387(10016):335-6.
Masmejan S, Musso D, Vouga M, Pomar L, Dashraath P, Stojanov M, et al. Zika virus. Pathogens. 2020;9(11):898.
de Oliveira WK, Cortez-Escalante J, De Oliveira WTGH, Carmo GMId, Henriques CMP, Coelho GE, et al. Increase in reported prevalence of microcephaly in infants born to women living in areas with confirmed Zika virus transmission during the first trimester of pregnancy—Brazil, 2015. Morbidity and Mortality Weekly Report. 2016;65(9):242-7.
de Melo Marques V, Santos CS, Santiago IG, Marques SM, Brasil MdGN, Lima TT, et al. Neurological complications of congenital Zika virus infection. Pediatric neurology. 2019;91:3-10.
Burger-Calderon R, Carrillo FB, Gresh L, Ojeda S, Sanchez N, Plazaola M, et al. Age-dependent manifestations and case definitions of paediatric Zika: a prospective cohort study. The Lancet Infectious Diseases. 2020;20(3):371-80.
Lindsey NP, Porse CC, Potts E, Hyun J, Sandhu K, Schiffman E, et al. Postnatally acquired Zika virus disease among children, United States, 2016–2017. Clinical Infectious Diseases. 2020;70(2):227-31.
Aguiar YPC, Cavalcanti AFC, de Alencar CRB, de Oliveira Melo AS, Cavalcanti SdLB, Cavalcanti AL. Chronology of the first deciduous tooth eruption in Brazilian children with microcephaly associated with zika virus: a longitudinal study. Pesquisa Brasileira em Odontopediatria e Clinica Integrada. 2018;18(1):3982.
Carvalho IF, Alencar PNB, Carvalho de Andrade MD, Silva PGdB, Carvalho EDF, Araújo LS, et al. Clinical and x-ray oral evaluation in patients with congenital Zika Virus. Journal of Applied Oral Science. 2019;27.
D'Agostino ÉS, Chagas JRLP, Cangussu MCT, Vianna MIP. Chronology and sequence of deciduous teeth eruption in children with microcephaly associated to the Zika virus. Special Care in Dentistry. 2020;40(1):3-9.
de Oliveira AMM, de Melo EGM, Mendes MLT, dos Santos Oliveira SJG, Tavares CSS, Vaez AC, et al. Oral and maxillofacial conditions, dietary aspects, and nutritional status of children with congenital Zika syndrome. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2020;130(1):71-7.
Leal MC, van der Linden V, Bezerra TP, de Valois L, Borges AC, Antunes MM, et al. Characteristics of dysphagia in infants with microcephaly caused by congenital Zika virus infection, Brazil, 2015. Emerging infectious diseases. 2017;23(8):1253.
Lopes-Silva J, Paiva SM, Abreu LG, Castro Martins C, Rabelo-Costa D, Ferrarez Bouzada MC, et al. Signs and symptoms of primary tooth eruption in preterm and low birth weight children. Journal of Dentistry for Children. 2021;88(2):94-100.
Marín IC, Sánchez AG, Reyes M, García JC, Torrealba RM, Rodríguez BA, et al. Síndrome congénito asociado a virus Zika. Bol venez infectol. 2019:72-8.
Tugwell P, Tovey D. PRISMA 2020. Journal of Clinical Epidemiology. 2021;134:A5-A6.
Moola S, Munn Z, Tufanaru C, Aromataris E, Sears K, Sfetcu R, et al. Chapter 7: Systematic reviews of etiology and risk. Joanna briggs institute reviewer's manual The Joanna Briggs Institute. 2017;5.
Gomes PN, Azevedo ID, do Amaral BA, Arrais NMR, Lima KCd. Microcephaly as a risk factor for dental alterations: A case‐control study. Oral Diseases. 2022.
Ribeiro RA, Mattos A, Meneghim MdC, Vedovello SA, Borges TMD, Santamaria Jr M. Oral and maxillofacial outcomes in children with microcephaly associated with the congenital Zika syndrome. European Journal of Orthodontics. 2021;43(3):346-52.
do Amaral BA, Gomes PN, Azevedo ID, Galvao HC, da Costa Oliveira AGR, Rabelo SGF. Prevalence of malocclusions in children with microcephaly associated with the Zika virus. American Journal of Orthodontics and Dentofacial Orthopedics. 2021;159(6):816-23.
Bayless NL, Greenberg RS, Swigut T, Wysocka J, Blish CA. Zika virus infection induces cranial neural crest cells to produce cytokines at levels detrimental for neurogenesis. Cell host & microbe. 2016;20(4):423-8.
Jaskoll T, Abichaker G, Htet K, Bringas Jr P, Morita S, Sedghizadeh PP, et al. Cytomegalovirus induces stage-dependent enamel defects and misexpression of amelogenin, enamelin and dentin sialophosphoprotein in developing mouse molars. Cells Tissues Organs. 2010;192(4):221-39.
Cobourne MT, Sharpe PT. Tooth and jaw: molecular mechanisms of patterning in the first branchial arch. Archives of oral biology. 2003;48(1):1-14.
Sajjadian N, Shajari H, Jahadi R, Barkett MG, Sajjadian A. Relationship between birth weight and time of first deciduous tooth eruption in 143 consecutively born infants. Pediatrics & Neonatology. 2010;51(4):235-7.
Allison PJ, Hennèquin M, Faulks D. Dental care access among individuals with Down syndrome in France. Special Care in Dentistry. 2000;20(1):28-34.
Oliveira JS, Prado Júnior RR, de Sousa Lima KR, de Oliveira Amaral H, Moita Neto JM, Mendes RF. Intellectual disability and impact on oral health: a paired study. Special Care in Dentistry. 2013;33(6):262-8.
Silva LVdO, Hermont AP, Magnani IQ, Martins CC, Borges‐Oliveira AC. Oral alterations in children with microcephaly associated to congenital Zika syndrome: A systematic review and meta‐analyses. Special Care in Dentistry. 2022.
Teixeira SA, Santos PCM, Batista AR, Albuquerque BN, Vasconcelos M, Borges-Oliveira AC. Assessment of oral hygiene in mentally disabled children. Revista Odonto Ciência. 2015;30(3):65-70.
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