Prevalence of anxiety and depression among celiac disease patients
Keywords:
celiac disease, anxiety, depressionAbstract
Background and Aim: Celiac disease is an immune-mediated intestinal condition with a 1% worldwide incidence caused by gluten sensitivity in a genetically predisposed individual. It manifests as gastrointestinal symptoms, malabsorption-related symptoms, and/or extra intestinal manifestations such as neuropsychiatric problems. The present study aimed to determine the prevalence of anxiety and depression in celiac disease patients. Patients and Method: This questionnaire based cross-sectional study was carried out on 126 celiac disease patients investigated in the Internal Medicine and Gastroenterology Department of District Headquarter Hospital, Charsadda Pakistan. All the patients with age ≥18 years old diagnosed with celiac disease based on positive serological test and biopsy confirmation were enrolled. The questionnaire consisted of demographic details, Generalized Anxiety Disorder-7 (GAD-7) score, and nine questions that assessed depressive symptoms. SPSS version 27 was used for data analysis. Results: The overall mean age was 36.5± 12.16 years. Of the 126 total patients, there were 98 (77.8%) female and 28 (22.2%) male. The incidence of anxiety and depressive symptoms were 84.1% (n=106) and 81% (n=102) respectively. There was no causal relationship found between any of the factors and the occurrence of anxiety or depression symptoms.
Downloads
References
Haj Ali S, Alqurneh R, Abu Sneineh A, et al. (June 01, 2023) The Prevalence of Anxiety and Depressive Symptoms Among Patients With Celiac Disease in Jordan. Cureus 15(6): e39842. DOI 10.7759/cureus.39842.
Singh P, Arora A, Strand TA, et al.: Global prevalence of celiac disease: systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2018, 16:823-36. 10.1016/j.cgh.2017.06.037.
Tapsas D, Hollén E, Stenhammar L, Fälth-Magnusson K: The clinical presentation of coeliac disease in 1030 Swedish children: changing features over the past four decades. Dig Liver Dis. 2016, 48:16-22. 10.1016/j.dld.2015.09.018
Kivelä L, Kaukinen K, Lähdeaho ML, et al.: Presentation of celiac disease in Finnish children is no longer changing: a 50-year perspective. J Pediatr. 2015, 167:1109-15. 10.1016/j.jpeds.2015.07.057
Ludvigsson JF, Bai JC, Biagi F, et al.: Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology. Gut. 2014, 63:1210-28. 10.1136/gutjnl-2013-306578.
Smith DF, Gerdes LU. Meta‐analysis on anxiety and depression in adult celiac disease. Acta Psychiatrica Scandinavica. 2012 Mar;125(3):189-93.
Germone M, Phu T, Slosky C, Pan Z, Jones A, Stahl M, Mehta P, Shull M, Ariefdjohan M, Liu E. Anxiety and Depression in Pediatric Patients with Celiac Disease: A Large Cross-Sectional Study. Journal of Pediatric Gastroenterology and Nutrition. 2022 Jun 1;75(2):181-5.
Barberis N, Quattropani MC, Cuzzocrea F. Relationship between motivation, adherence to diet, anxiety symptoms, depression symptoms and quality of life in individuals with celiac disease. Journal of psychosomatic research. 2019 Sep 1;124:109787.
Trovato CM, Raucci U, Valitutti F, Montuori M, Villa MP, Cucchiara S, Parisi P: Neuropsychiatric manifestations in celiac disease. Epilepsy Behav. 2019, 99:106393. 10.1016/j.yebeh.2019.06.036
Slim M, Rico-Villademoros F, Calandre EP: Psychiatric comorbidity in children and adults with glutenrelated disorders: a narrative review. Nutrients. 2018, 10:875. 10.3390/nu10070875
Alkhayyat M, Qapaja T, Aggarwal M, et al.: Epidemiology and risk of psychiatric disorders among patients with celiac disease: a population-based national study. J Gastroenterol Hepatol. 2021, 36:2165-70.10.1111/jgh.15437
Clappison E, Hadjivassiliou M, Zis P: Psychiatric manifestations of coeliac disease, a systematic review and meta-analysis. Nutrients. 2020, 12:142. 10.3390/nu12010142
van Hees NJ, Van der Does W, Giltay EJ: Coeliac disease, diet adherence and depressive symptoms . J Psychosom Res. 2013, 74:155-60. 10.1016/j.jpsychores.2012.11.007.
Sharma N, Singh K, Senapati S. Celiac disease poses significant risk in developing depression, anxiety, headache, epilepsy, panic disorder, dysthymia: A meta-analysis. Indian Journal of Gastroenterology. 2021:1-0.
Valitutti F, Trovato CM, Montuori M, Cucchiara S. Pediatric celiac disease: follow-up in the spotlight. Adv Nutr. 2017;8:356–61.
Biagetti C, Gesuita R, Gatti S, Catassi C. Quality of life in children with celiac disease: a paediatric cross-sectional study. Dig Liver Dis. 2015;47:927–32.
Smith DF, Gerdes LU. Meta-analysis on anxiety and depression in adult celiac disease. Acta Psychiatr Scand. 2012;125:189–9.
Esenyel S, Unal F, Vural P. Depression and anxiety in child and adolescents with follow-up celiac disease and in their families. Turk J Gastroenterol. 2014;25:381–5.
J.P.W. Burger et al. Systematic review with meta-analysis: dietary adherence influences normalization of health-related quality of life in coeliac disease Clin. Nutr. (2017)
N.J.M. Van Hees et al. Coeliac disease, diet adherence and depressive symptoms J. Psychosom. Res. (2013)
N. Barberis et al. The relationship between coping, emotion regulation and quality of life of patients on dialysis Int. J. Psychiatry Med. (2017)
N. Barberis et al. Trait EI in the relationship between needs fulfilment and symptoms and attitudes associated with EDs Ment Health & Prev. (2018)
N. Barberis et al. Role of emotional intelligence as a mediating factornetween Uncertainty and Anxiety Hospital in chroninc renal patients Illn. Crisis Loss (2016)
AlHadi AN, AlAteeq DA, Al-Sharif E, et al.: An arabic translation, reliability, and validation of Patient Health Questionnaire in a Saudi sample. Ann Gen Psychiatry. 2017, 16:32. 10.1186/s12991-017-0155-1
Barghouti F, Al Masalha A, Fayyomi H, Mari’e L, Ahmad M: Prevalence of generalized anxiety disorder in family practice clinics. Clin Pract. 2018, 15:945-51. 10.4172/clinical-practice.1000432
Jaradat AM: Prevalence of depression among a sample of university students in Jordan . Univ Sharjah J Hum Soc Sci. 2012, 9:177-97.
Rostami-Nejad M, Taraghikhah N, Ciacci C, et al.: Anxiety symptoms in adult celiac patients and the effect of a gluten-free diet: an Iranian nationwide study. Inflamm Intest Dis. 2020, 5:42-7. 10.1159/000505657.
Kelly DL, Demyanovich HK, Eaton WW, Cascella N, Jackson J, Fasano A, Carpenter WT: Anti gliadin antibodies (AGA IgG) related to peripheral inflammation in schizophrenia. Brain Behav Immun. 2018, 69:57-9. 10.1016/j.bbi.2017.10.020.
Dehhaghi M, Kazemi Shariat Panahi H, Guillemin GJ: Microorganisms, tryptophan metabolism, and kynurenine pathway: a complex interconnected loop influencing human health status. Int J Tryptophan Res. 2019, 12:10.1177/1178646919852996
Published
How to Cite
Issue
Section
Copyright (c) 2023 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
