Characterization, development and evaluation of a cream by using terminalia chebula and cucumber sativus extracts

Aleena Haider; Bushra Nasir; Iqra Tariq; Komal Arshad; Marrium Razzaq; Hafsa Irfan; Furqan Iqbal

doi:10.53730/ijhs.v7nS1.14410

Authors

Aleena Haider
aleena.haider184@gmail.com
M. Phill Pharmaceutics, Lecturer at Limit Institute of Health Sciences, Sahiwal
Bushra Nasir PhD Pharmacy, Assistant Professor Pharmaceutics at Bahauddin Zakariya University, Multan
Iqra Tariq M. Phill Pharmaceutics, Lecturer at Ehsan College of Health Sciences and Professional Studies, Multan
Komal Arshad M. Phill Pharmaceutics, Principal at Bright Institute of Allied Health Sciences, Multan
Marrium Razzaq Pharm-D, Branch Manager in Dvago Pharmacy and Wellness Experts Nova Care PVT Ltd, Multan
Hafsa Irfan Pharm-D, Retail Pharmacist at Dvago Pharmacy and Wellness Experts Nova Care PVT Ltd, Multan
Furqan Iqbal PhD in Pharmaceutics, Assistant Professor Pharmaceutics at Bahauddin Zakariya University, Multan

Keywords:

Terminalia Chebula, Cucumber Sativus, Melanin, freckles, moisture, sebum, transepidermal loss

Abstract

Background: Continual exposure to the sun's ultraviolet radiation damages skin. Freckles are little brown patches that develop on the skin after repeated sun exposure. Terminalia chebula and Cucumber Sativus extracts-infused water in oil (W/O) emulsion is created, that has anti-freckle and emollient effect. Methodology: Base with no extract and formulation containing three different extract concentrations 4% of Terminalia Chebula with 1% Cucumber Sativus, 5% T. Chebula with 2% C. Sativus and 6% of T. Chebula with 3% of C. Sativus are formulated and after 4 weeks of study and their stability parameters are evaluated at 8^oC, 25^oC, 40^oC and 40^oC + 75RH. Different parameters such as anti freckle effect, skin melanin, skin moisture content, sebum level and TEW loss level are investigated by applying these formulations on the volunteer’s cheeks for 4 weeks. Results: Skin melanin levels, sebum level, moisture level and TEW loss level of three formulations containing both plant extracts are significant statistically (p < 0.05). Skin melanin level and TEW loss are decreased after application of cream. But skin moisture and sebum level are increased after application of formulation.

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