Comparison of foam sclerotherapy and cyanoacrylate glue for preventing the recurrence of varicose veins

Farid Ullah; Maila Aslam; Rabeea Zia; Inam Ullah; Muhammad Usman Khalid; Khurshid Anwar

doi:10.53730/ijhs.v7nS1.14430

Authors

Farid Ullah
faridkn278@gmail.com
Department of Vascular Surgery, Combined Military Hospital (CMH), Peshawar
Maila Aslam District Surgeon, THQ Hospital Kharian
Rabeea Zia Pakistan kidney and Liver hospital, Lahore
Inam-u-llah Department of Food Science and Technology, The University of Haripur
Muhammad Usman Khalid Faculty of Food Science and Nutrition, BZU, Multan
Khurshid Anwar Department of Food Science and Technology, The University of Haripur

Keywords:

Varicose veins, Cyanoacrylate glue, Foam sclerotherapy, Recurrence prevention, Treatment efficacy

Abstract

Background: Varicose veins are a common vascular disorder that can cause discomfort and aesthetic concerns. Cyanoacrylate glue and foam sclerotherapy are treatment modalities used to prevent recurrence of varicose veins, but their comparative effectiveness is not well established. Objective: This research compared the effectiveness of foam sclerotherapy and cyanoacrylate glue in preventing varicose vein recurrence. Methods: A randomized controlled trial was conducted from June to December 2022, including 140 participants equally divided into cyanoacrylate glue and foam sclerotherapy groups. Convenience sampling was employed to recruit participants from clinics and hospitals. Data on demographic characteristics, clinical severity, treatment outcomes, and patient satisfaction were collected and analyzed. Results: In comparison to the foam sclerotherapy group, the cyanoacrylate glue group showed considerably lower recurrence rates (10.7% vs. 14.6%), greater symptomatic recovery (88.9% vs. 82.5%), and higher aesthetic satisfaction (95.3% vs. 90.1%). Patient compliance was higher (94.2%) and pain levels were lower (2.3 out of 10) in the cyanoacrylate glue group. Conclusion: Cyanoacrylate glue treatment showed superior efficacy in preventing varicose vein recurrence, improving symptoms, and enhancing patient satisfaction compared to foam sclerotherapy.

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References

Bootun, R., Lane, T. R., & Davies, A. H. (2016). A comparison of thermal and non-thermal ablation. Reviews in Vascular Medicine, 4, 1-8.

Bootun, R., Onida, S., Lane, T. R., & Davies, A. H. (2022). Varicose veins. Surgery (Oxford).

Davies, H., Darvall, K., & Bradbury, A. W. (2017). Foam sclerotherapy for ablation of the saphenous veins, varicose tributaries, and perforating veins. Handbook of Venous and Lymphatic Disorders, 421-428.

Gao, R. D., Qian, S. Y., Wang, H. H., Liu, Y. S., & Ren, S. Y. (2022). Strategies and challenges in treatment of varicose veins and venous insufficiency. World Journal of Clinical Cases, 10(18), 5946.

Gibson, K., Minjarez, R., Gunderson, K., & Ferris, B. (2019). Need for adjunctive procedures following cyanoacrylate closure of incompetent great, small and accessory saphenous veins without the use of postprocedure compression: Three-month data from a postmarket evaluation of the VenaSeal System (the WAVES Study). Phlebology, 34(4), 231-237.

Kemp, N. (2017). A synopsis of current international guidelines and new modalities for the treatment of varicose veins. Australian Family Physician, 46(4), 229-233.

Koramaz, İ., El Kılıç, H., Gökalp, F., Bitargil, M., Bektaş, N., Engin, E., ... & Bozkurt, A. K. (2017). Ablation of the great saphenous vein with nontumescent n-butyl cyanoacrylate versus endovenous laser therapy. Journal of Vascular Surgery: Venous and Lymphatic Disorders, 5(2), 210-215.

Kucukguven, A., & A Khalil, R. (2013). Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins. Current drug targets, 14(3), 287-324.

Lam, Y. L., De Maeseneer, M., Lawson, J., De Borst, G. J., & Boersma, D. (2017). Expert review on the VenaSeal® system for endovenous cyano-acrylate adhesive ablation of incompetent saphenous trunks in patients with varicose veins. Expert review of medical devices, 14(10), 755-762.

McAree, B. J. (2015). Optimisation of minimally invasive therapy for primary varicose veins (Doctoral dissertation, University of Leeds).

Morrison, N., Gibson, K., Vasquez, M., Weiss, R., & Jones, A. (2020). Five-year extension study of patients from a randomized clinical trial (VeClose) comparing cyanoacrylate closure versus radiofrequency ablation for the treatment of incompetent great saphenous veins. Journal of Vascular Surgery: Venous and Lymphatic Disorders, 8(6), 978-989.

Onida, S., Lane, T. R., Bootun, R., & Davies, A. H. (2019). Varicose veins and their management. Surgery (Oxford), 37(2), 73-80.

Poredos, P., Spirkoska, A., Rucigaj, T., Fareed, J., & Jezovnik, M. K. (2015). Do blood constituents in varicose veins differ from the systemic blood constituents?. European Journal of Vascular and Endovascular Surgery, 50(2), 250-256.

Prasad BP, K., Joy, B., Toms, A., & Sleeba, T. (2018). Treatment of incompetent perforators in recurrent venous insufficiency with adhesive embolization and sclerotherapy. Phlebology, 33(4), 242-250.

Yavuz, T., Acar, A. N., Aydın, H., & Ekingen, E. (2018). A retrospective study of a new n-butyl-2-cyanoacrylate glue ablation catheter incorporated with application guiding light for the treatment of venous insufficiency: twelve-month results. Vascular, 26(5), 547-555.

Yie, K. (2022). Symptom improvement after cyanoacrylate glue adhesion and endovenous laser ablation in low-grade CEAP clinical classes. Journal of Vascular Surgery: Venous and Lymphatic Disorders, 10(2), 360-369.