Exploring the anti-inflammatory and anti-pyretic potentials of methanolic and aqueous fruit extracts from ceiba speciosa
Keywords:
ceiba speciosa, anti-inflammatory effect, antipyretic effect, rat models, fruit extractAbstract
Background and Aim: Ceiba speciosa (C.speciosa) has been used for treating various ailments as a folklore remedy in particularly as an anti-inflammatory agent. The fruit of this plant, however, has not been extensively investigated for its pharmacological activities. Keeping in view the anti-inflammatory activity of the leaves and flowers, this study was intended to explore the anti-inflammatory potential of the fruit of this plant in rats. Materials and Methods: Carrageenan induced inflammation model was applied to study the effects of Methanol and Aqueous extract of Ceiba speciosa fruit in Wister rats of both sexes. Diclofenac sodium (10mg/kg) was used as a standard reference for this model. 9 groups of animals were made prior to the administration of methanol extract of Ceiba speciosa fruit. Yeast induced pyrexia model was used to study the anti-pyretic effect of methanol and aqueous extracts of Ceiba speciosa fruit in rats. Paracetamol (150mg/kg) was used as a standard reference for investigation of anti-pyretic effect. Results: Data compiled at the end of the study illustrated that methanol extract of C. speciosa fruit showed significant (p < 0.0001) anti-inflammatory effect at doses of 200mg/kg B.W., 400 mg/kg B.W. and 600mg/kg B.W. when related with disease control group.
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