The  role of statins in early sepsis in post cardiac surgery

Ahmed Mohammed Hassan Mostafa; Nehal Gamal Eldin Noh; Sheirf Wadie Nashed; Mayar Hassan El Sersy; Mohamed Yosef Mohamed

doi:10.53730/ijhs.v5nS2.14669

Authors

Ahmed Mohammed Hassan Mostafa
Ahm_hassan79@yahoo.com
Consultant of intensive care medicine national heart institute
Nehal Gamal Eldin Noh Professor of Anesthesia and Critical Care Medicine, Faculty of Medicine, Ain shams University
Sheirf Wadie Nashed Professor of Anesthesia and Critical Care Medicine, Faculty of Medicine, Ain shams University
Mayar Hassan El Sersy Lecturer of Anesthesia and Critical Care Medicine, Faculty of Medicine, Ain shams University
Mohamed Yosef Mohamed Lecturer of Anesthesia and Critical Care Medicine, Faculty of Medicine, Ain shams University

Keywords:

early sepsis, statin therapy, atorvastatin, inflammatory response, prognostic implications

Abstract

Background: Sepsis is a condition where the body's immune system overreacts to an infection, leading to a widespread inflammatory reaction. Present therapeutic endeavors predominantly concentrate on medications that have the ability to obstruct stages within the inflammatory cascade. Objective: This study sought to examine the influence of statin medication on early sepsis, with a focus on its pleiotropic effects and prognostic implications. A total of fifty patients diagnosed with early sepsis were included in the study. These patients were admitted to the critical care departments of Ain Shams University and the National Heart Institute between February 2012 and February 2013. The patients were categorized into two cohorts: the statins group, which consisted of individuals undergoing heart surgery and getting a daily dose of 80 mg of atorvastatin for four consecutive days, in addition to traditional sepsis therapy; and the control group, which only received conventional sepsis therapy. Results: The results showed that a brief period of intense statin medication led to a considerable decrease in levels of C-reactive protein (CRP) and procalcitonin (PCT) by day 4. Although there was no significant decrease in nitric oxide (Nox) levels, the total cholesterol levels remained unchanged.

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