The effect of complementary prana therapy on serotonin levels, Perceived Stress Scale (PSS) Scores and Psoriasis Area and Severity Index (PASI) scores in psoriasis vulgaris patients

https://doi.org/10.53730/ijhs.v8n1.14795

Authors

  • I Gusti Ayu Risma Pramita Udayana University, Denpasar | Prof. Dr. IGNG Ngoerah Hospital, Denpasar, Indonesia
  • Luh Made Mas Rusyati Udayana University, Denpasar | Prof. Dr. IGNG Ngoerah Hospital, Denpasar, Indonesia
  • Ni Ketut Sri Diniari Udayana University, Denpasar | Prof. Dr. IGNG Ngoerah Hospital, Denpasar, Indonesia
  • Nyoman Suryawati Udayana University, Denpasar | Prof. Dr. IGNG Ngoerah Hospital, Denpasar, Indonesia
  • Ketut Kwartantaya Winaya Udayana University, Denpasar & Prof. Dr. IGNG Ngoerah Hospital, Denpasar, Indonesia
  • Ni Made Dwi Puspawati Udayana University, Denpasar & Prof. Dr. IGNG Ngoerah Hospital, Denpasar, Indonesia

Keywords:

complementary therapy, perceived stress scale, prana, psoriasis vulgaris, serotonin

Abstract

Introduction: Psoriasis vulgaris is a skin problem that has become a global concern with an increase in new cases reaching around 150,000 cases each year. This condition certainly reduces the quality of life and increases the patient's anxiety regarding the disease they are experiencing. This research was conducted to examine the effect of pranic complementary therapy on serotonin levels, Perceived Stress Scale (PSS) scores and Psoriasis Area and Severity Index (PASI) scores in psoriasis vulgaris patients. Method: Experimental research using a single group pre-test and post-test study design approach was carried out on 17 patients with psoriasis vulgaris. The resulting data was then analyzed using SPSS. Results: This study showed that there was a significant decrease between pre and post-therapy serotonin levels with a mean difference of 44.69 ng/ml (p=0.002). Providing pranic therapy can also reduce the severity of psoriasis through (PASI) by 2.92 ± 3.82 (p = 0.006; 95% CI = 0.95-4.89). Meanwhile, prana was also found to reduce the stress index (PSS) by 3.88 ± 4.54 (p = 0.003; 95% CI = 1.10-6.21). Conclusion: Complementary pranic therapy affects serotonin levels, Perceived Stress Scale (PSS) scores and Psoriasis Area and Severity Index (PASI) scores in psoriasis vulgaris patients.

Downloads

Download data is not yet available.

References

Agustina, M., Hidayati, A. N., & Hasanatuludhhiyah, N. (2020). Side Effects of Methotrexate for Psoriasis Therapy. Berkala Ilmu Kesehatan Kulit Dan Kelamin, 32(2), 98.

Alakbarov, H., Sağduyu, İ. E., Acar, A., Türk, B. G., & Ünal, İ. (2021). Age distribution of psoriasis clinical types: A single center study. TURKDERM-Turkish Archives of Dermatology and Venereology, 55(4), 193-198.

Alverina, L., Hidajat, D., Hendrawan, I. W., & Medikawati, I. G. A. A. R. (2021). Karakteristik penderita psoriasis di poliklinik rawat jalan dermatologi dan venereologi Rumah Sakit Umum Daerah Provinsi Nusa Tenggara Barat periode Januari 2016–Desember 2020. Intisari Sains Medis, 12(3), 880-885.

As’ad Naufal, D., Kusumastuti, E. H., & Hidayati, A. N. (2021). Risk Factor Profile and Quality of Life of Psoriasis Vulgaris.

Astuti, C. P., Widyawati, M. N., & Suryono, S. (2019). Application Model of Pranic Healing Therapy for Emotional Stress Using Accurate Bio-Well GDV Camera. In E3S Web of Conferences (Vol. 125, p. 05005). EDP Sciences.

Au, S. C., Madani, A., Alhaddad, M., Alkofide, M., & Gottlieb, A. B. (2013). Comparison of the efficacy of biologics versus conventional systemic therapies in the treatment of psoriasis at a comprehensive psoriasis care center. Journal of drugs in dermatology: JDD, 12(8), 861-866.

Babalola, E., Noel, P., & White, R. (2017). The biopsychosocial approach and global mental health: Synergies and opportunities. Indian journal of social psychiatry, 33(4), 291-296.

Boham, M. P., Suling, P. L., & Pandaleke, H. E. (2016). Profil psoriasis di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. RD Kandou Manado periode Januari 2013–Desember 2015. e-CliniC, 4(2).

Budianti, W. K., Anindya, S., Debinta, A. A., Novianto, E., Fitri, E. M., & Halim, E. (2019). Kesesuaian Tata Laksana Psoriasis dengan Panduan Praktik Klinis (PPK) Di RSUPN Dr. Cipto Mangunkusumo. Media Dermato Venereologica Indonesiana, 46(4).

Carlin, C. S., Feldman, S. R., Krueger, J. G., Menter, A., & Krueger, G. G. (2004). A 50% reduction in the Psoriasis Area and Severity Index (PASI 50) is a clinically significant endpoint in the assessment of psoriasis. Journal of the American Academy of Dermatology, 50(6), 859-866. https://doi.org/10.1016/j.jaad.2003.09.014

Castellar, J. I., Fernandes, C. A., & Tosta, C. E. (2014). Beneficial effects of pranic meditation on the mental health and quality of life of breast cancer survivors. Integrative cancer therapies, 13(4), 341-350.

Chen, Y., Wei, L., Song, Y., Zhang, R., Kuai, L., Li, B., & Wang, R. (2023). Life quality among psoriasis patients based on Dermatology Life Quality Index evaluation and its association with psoriasis severity in China: a cross-sectional study. Annals of Medicine, 55(1), 2231847.

Dewi, D. A. P. N., & Indira, I. G. (2018). Insiden dan profil psoriasis di poliklinik kulit dan kelamin Rumah Sakit Umum Pusat Sanglah Denpasar periode Januari 2012 sampai Desember 2014. E-Jurnal Med Udayana, 7(9), 1-7.

Dewi, F. D. K. (2021). Terapi pada Psoriasis. Jurnal Medika Hutama, 2(02 Januari), 631-641.

Diagnostika. (2013). Instruction for use Serotonin ELISA.

Diniari, N. K. S., Ayu, K., & Widiana, G. R. (2023). The effectiveness of pranic complementary therapy to reduce post COVID-19 anxiety in elderly. International Journal of Health & Medical Sciences, 6(1), 1-6. https://doi.org/10.21744/ijhms.v6n1.2069

Easthope, G., Tranter, B., & Gill, G. (2000). General practitioners’ attitudes toward complementary therapies. Social Science & Medicine, 51(10), 1555-1561. https://doi.org/10.1016/S0277-9536(00)00048-4

El-Mawla, A., Hashim, A. A., & Zidan, A. S. (2018). Assessment of the effect of psoriasis on male sexual function. Human Andrology, 8(3), 69-75.

El-Mawla, A., Hashim, A. A., & Zidan, A. S. (2018). Assessment of the effect of psoriasis on male sexual function. Human Andrology, 8(3), 69-75.

Fiorentino, D., Ho, V., Lebwohl, M. G., Leite, L., Hopkins, L., Galindo, C., ... & Langley, R. G. (2017). Risk of malignancy with systemic psoriasis treatment in the Psoriasis Longitudinal Assessment Registry. Journal of the American Academy of Dermatology, 77(5), 845-854. https://doi.org/10.1016/j.jaad.2017.07.013

Gamret, A. C., Price, A., Fertig, R. M., Lev-Tov, H., & Nichols, A. J. (2018). Complementary and alternative medicine therapies for psoriasis: a systematic review. JAMA dermatology, 154(11), 1330-1337.

Garber, C., Plotnikova, N., Au, S. C., Sorensen, E. P., & Gottlieb, A. (2015). Biologic and Conventional Systemic Therapies Show Similar Safety and Efficacy in Elderly and Adult Patients With Moderate to Severe Psoriasis. Journal of drugs in dermatology: JDD, 14(8), 846-852.

Gaston, L. O. U. I. S. E., Crombez, J. C., Lassonde, M., Bernier-Buzzanga, J., & Hodgins, S. (1991). Psychological stress and psoriasis: experimental and prospective correlational studies. Acta dermato-venereologica. Supplementum, 156, 37-43.

Griffiths, C. E. M., Armstrong, A. W., Gudjonsson, J. E., & Barker, J. N. W. N. (2021). Psoriasis Lancet 397 (10281): 1301–1315.

Guillet, C., Seeli, C., Nina, M., Maul, L. V., & Maul, J. T. (2022). The impact of gender and sex in psoriasis: What to be aware of when treating women with psoriasis. International journal of women's dermatology, 8(2), e010.

Hägg, D., Sundström, A., Eriksson, M., & Schmitt-Egenolf, M. (2017). Severity of psoriasis differs between men and women: a study of the clinical outcome measure psoriasis area and severity index (PASI) in 5438 Swedish register patients. American journal of clinical dermatology, 18, 583-590.

Han, J. H., Bang, C. H., Han, K., Ryu, J. Y., Lee, J. Y., Park, Y. M., & Lee, J. H. (2021). The risk of psoriasis in patients with allergic diseases: a nationwide population-based cohort study. Allergy, Asthma & Immunology Research, 13(4), 638-645.

Henning, S. W., Jaishankar, D., Barse, L. W., Dellacecca, E. R., Lancki, N., Webb, K., ... & Le Poole, I. C. (2020). The relationship between stress and vitiligo: Evaluating perceived stress and electronic medical record data. PLoS One, 15(1), e0227909.

Krisnarto, E., Novitasari, A., & Aulirahma, D. M. (2017). Faktor Prediktor Kualitas Hidup Pasien Psoriasis : Studi Cross Sectional. Jurnal Unimus, 49, 43–51.

Marek-Jozefowicz, L., Czajkowski, R., Borkowska, A., Nedoszytko, B., Żmijewski, M. A., Cubała, W. J., & Slominski, A. T. (2022). The brain–skin axis in psoriasis—psychological, psychiatric, hormonal, and dermatological aspects. International journal of molecular sciences, 23(2), 669.

Maul, J. T., Augustin, M., Sorbe, C., Conrad, C., Anzengruber, F., Mrowietz, U., ... & Navarini, A. A. (2021). Association of sex and systemic therapy treatment outcomes in psoriasis: a two‐country, multicentre, prospective, noninterventional registry study. British Journal of Dermatology, 185(6), 1160-1168.

Maximino, J., Coimbra, M., & Pedrosa, J. (2022). Detection of COVID-19 in Point of Care Lung Ultrasound. In 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) (pp. 1527-1530). IEEE.

Minxue, S. H. E. N., Duling, C. A. O., Yi, X. I. A. O., Kuang, Y., Danrong, J. I. N. G., Yajia, L. I., ... & Wu, Z. H. U. (2021). Serum 5-hydroxytryptamine is related to psoriasis severity in patients with comorbid anxiety or depression. Acta Dermato-Venereologica, 101(8).

Mrowietz, U. (2018). Psoriasis, stress, age and more. British Journal of Dermatology, 178(4), 830-831.

Nittur, A., Pavan, B., Ganapathy, R., Dorai, V. K., & Singhal, S. (2023). Pranic Healing as a Complementary Therapy in Diabetic Foot Ulcer Management: A Randomised, Controlled, Double-Blind Trial. Global Advances in Integrative Medicine and Health, 12, 27536130231183429.

Nurjanah, D. S. (2017). Tenaga Prana sebagai Terapi Alternatif bagi Penyembuhan Penyakit Pasien (Studi Terhadap Metode Penyembuhan Alternatif di Klinik Pengobatan Yayasan Majlis Taklim Al-Ukhuwah Buah Batu Bandung). Jurnal Syifa Al-Qulub, 1(2), 160-181.

Parisi, R., Symmons, D. P., Griffiths, C. E., & Ashcroft, D. M. (2013). Global epidemiology of psoriasis: a systematic review of incidence and prevalence. Journal of Investigative Dermatology, 133(2), 377-385. https://doi.org/10.1038/jid.2012.339

Preller, K. H., Pokorny, T., Hock, A., Kraehenmann, R., Stämpfli, P., Seifritz, E., ... & Vollenweider, F. X. (2016). Effects of serotonin 2A/1A receptor stimulation on social exclusion processing. Proceedings of the National Academy of Sciences, 113(18), 5119-5124.

Rajagopal, R., Jois, S. N., Mallikarjuna Majgi, S., Anil Kumar, M. N., & Shashidhar, H. B. (2018). Amelioration of mild and moderate depression through Pranic Healing as adjuvant therapy: randomised double-blind controlled trial. Australasian Psychiatry, 26(1), 82-87.

Rasmana, N. K. H. (2021). Pengaruh Terapi Pranic Healing Terhadap Tingkat Depresi, Ansietas Dan Stress Pasien Dengan Carcinoma Di Rumah Sakit X Denpasar (Doctoral dissertation, STIKES BINA USADA BALI).

Rendon, A., & Schäkel, K. (2019). Psoriasis pathogenesis and treatment. International journal of molecular sciences, 20(6), 1475.

Ronpirin, C., & Tencomnao, T. (2010). Psoriasis: A review of the role of serotonergic system. African Journal of Biotechnology, 9(11), 1528-1534.

Ruisoto, P., López-Guerra, V. M., Paladines, M. B., Vaca, S. L., & Cacho, R. (2020). Psychometric properties of the three versions of the Perceived Stress Scale in Ecuador. Physiology & Behavior, 224, 113045. https://doi.org/10.1016/j.physbeh.2020.113045

Salvan, P., Fonseca, M., Winkler, A. M., Beauchamp, A., Lerch, J. P., & Johansen-Berg, H. (2023). Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks. Nature neuroscience, 26(1), 53-63.

Segar, D., Praharsini, I. G. A. A., & Indira, I. E. (2019). Prevalence and clinical manifestations of patients with psoriasis in RSUP Sanglah from 2017 to 2018. Intisari Sains Medis, 10(3).

Shatri, H. (2023). Perbedaan Serotonin Plasma dan Kortisol Saliva terhadap Gejala Depresi pada Pasien Pasca Sindrom Koroner Akut. Jurnal Penyakit Dalam Indonesia, 10(3), 123–129.

Stockmeier, C. A. (2003). Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter. Journal of psychiatric research, 37(5), 357-373. https://doi.org/10.1016/S0022-3956(03)00050-5

Sui, C. K. (2004). Miracles through pranic healing: Practical manual on energy healing. Energetic Solutions, Inc..

Suwarsa, O., Khairani, F. A., Isneny, S. U., Avriyanti, E., Dharmadji, H. P., Pangastuti, M., ... & Gunawan, H. (2021). The Effect of Systemic Methotrexate and Cyclosporine Combination Therapy inPsoriasis Vulgaris Patients in Bandung, Indonesia. Berkala Ilmu Kesehat Kulit dan Kelamin, 33(3), 200.

Takeshita, J., Grewal, S., Langan, S. M., Mehta, N. N., Ogdie, A., Van Voorhees, A. S., & Gelfand, J. M. (2017). Psoriasis and comorbid diseases: epidemiology. Journal of the American Academy of Dermatology, 76(3), 377-390. https://doi.org/10.1016/j.jaad.2016.07.064

Thorslund, K. (2012). Serotonergic mechanisms in psoriasis. Karolinska Institutet (Sweden).

Thungady, E., Rusyati, L. M. M., & Praharsini, I. G. A. A. (2020). Kadar serotonin serum yang rendah merupakan factor resiko terjadinya eritema nodusum leprosum. Medicina, 51(1), 23–27.

Wardhana, M., Windari, M., Puspasari, N., & Suryawati, N. (2019). Role of serotonin and dopamine in psoriasis: a case-control study. Open Access Macedonian Journal of Medical Sciences, 7(7), 1138–1142.

Woźniak, E., Owczarczyk-Saczonek, A., & Placek, W. (2021). Psychological Stress, Mast Cells, and Psoriasis—Is There Any Relationship?. International journal of molecular sciences, 22(24), 13252.

Yudistira, K. A., & Wiraguna, A. A. G. P. (2014). Gambaran Karakteristik Kasus Psoriasis Vulgaris di Poliklinik Penyakit Kulit dan Kelamin RSUD Kabupaten Buleleng Tahun 2012-2013. Jurnal Medika Udayana, 3(9), 1–10.

Zachariae, R., Øster, H., Bjerring, P., & Kragballe, K. (1996). Effects of psychologic intervention on psoriasis: a preliminary report. Journal of the American Academy of Dermatology, 34(6), 1008-1015. https://doi.org/10.1016/S0190-9622(96)90280-7

Zhang, C. S., May, B., Yan, Y., Yu, J. J., Yao, D., Chang, S., ... & Xue, C. C. (2016). Terms referring to psoriasis vulgaris in the classical Chinese medicine literature: a systematic analysis. Complementary Therapies in Medicine, 25, 55-60. https://doi.org/10.1016/j.ctim.2015.12.014

Published

08-03-2024

How to Cite

Pramita, I. G. A. R., Rusyati, L. M. M., Diniari, N. K. S., Suryawati, N., Winaya, K. K., & Puspawati, N. M. D. (2024). The effect of complementary prana therapy on serotonin levels, Perceived Stress Scale (PSS) Scores and Psoriasis Area and Severity Index (PASI) scores in psoriasis vulgaris patients. International Journal of Health Sciences, 8(1), 66–82. https://doi.org/10.53730/ijhs.v8n1.14795

Issue

Section

Peer Review Articles