Emerging antibiotic resistance profiles in urinary tract infections among the elderly: A critical review

Sami Ullah; Shahab Ali Khan; Syed Hassan Iftikhar; Tariq Shah; Muhammad Osama; Izat Ullah; Javaria Ismail; Kashif Ali; Naqeeb Ullah; Sundas Safdar; Hanifullah Hanfi

doi:10.53730/ijhs.v8nS1.14875

Authors

Sami Ullah
Kmcite033@gmail.com
Resident Physician, General Medicine, Medical A Ward Lady Reading Hospital Peshawar
Shahab Ali Khan Resident physician, Internal Medicine, Medical A ward, Lady Reading Hospital Peshawar
Syed Hassan Iftikhar House Officer, Internal Medicine, Medicine D Ward, MTI Lady Reading Hospital
Tariq Shah House Officer, Internal Medicine, Lady Reading Hospital Peshawar
Muhammad Osama House Officer, Medicine Department, Lady Reading Hospital Peshawar
Izat Ullah Resident Surgeon, General Surgery, Medical Complex Quetta
Javaria Ismail Final Year MBBS Medical Student, Women Medical and Dental College Abbottabad
Kashif Ali Resident physician, Internal medicine, Lady Reading Hospital, Peshawar
Naqeeb Ullah Resident physician, Internal Medicine, Lady Reading Hospital Peshawar
Sundas Safdar Resident Radiologist, Radiology, Lady Reading Hospital Peshawar
Hanifullah Hanfi Medical Student, MBBS, Khyber Medical University, Peshawar

Keywords:

Antibiotic Resistance, Urinary Tract Infections, Elderly Population, Emergence of Resistance, Treatment Challenges

Abstract

Antibiotic resistance is an increasing danger to treating UTIs in aging patients. These assessments found a regarding raise in multidrug-resistant bacteria those making old-style antibiotics less effective. The weakened immune systems, numerous healthcare exposures, and several chronic conditions in elderly patients subsidize to this resistance. These evaluations explore other strategies outside antibiotics. The capable options include cranberry for anticipation, immune-boosting vaccines, and estrogen therapy for postmenopausal women to decrease repetition. Those rapid and precise diagnostic apparatuses like multiplex PCR panels can also recover treatment by identifying the specific bacteria and its antibiotic vulnerability. However antibiotic stewardship programs are crucial to fight resistance. So these programs promote evidence-based prescribing, track antibiotic use, and educate healthcare benefactors on appropriate usage. The continuous monitoring of resistance designs is also important to guide treatment conclusions and public health policies. At last the collaboration among healthcare providers, researchers, and policymakers is highlighted. This cooperation is critical to progress effective approaches to combat resistance, enhance treatment for the elderly, and preserve the upcoming of antibiotics.

Downloads

Download data is not yet available.

References

András, M. (2020). Strategies to Control the Emerging Bacterial Antibioticresistance in Urology Szegedi Tudomanyegyetem (Hungary)].

Bader, M. S., Loeb, M., Leto, D., & Brooks, A. A. (2020). Treatment of urinary tract infections in the era of antimicrobial resistance and new antimicrobial agents. Postgraduate medicine, 132(3), 234-250.

Bilsen, M. P., Jongeneel, R. M., Schneeberger, C., Platteel, T. N., Van Nieuwkoop, C., Mody, L., Caterino, J. M., Geerlings, S. E., Köves, B., & Wagenlehner, F. (2023). Definitions of urinary tract infection in current research: a systematic review. Open forum infectious diseases,

Byron, J. K. (2019). Urinary tract infection. Veterinary Clinics: Small Animal Practice, 49(2), 211-221.

de Llano, D. G., Moreno-Arribas, M. V., & Bartolomé, B. (2021). Cranberry Polyphenols and Prevention against Urinary Tract Infections: A Brief Review. Current Advances in Chemistry and Biochemistry, 132.

Gajdács, M., Ábrók, M., Lázár, A., & Burián, K. (2021). Urinary tract infections in elderly patients: A 10-year study on their epidemiology and antibiotic resistance based on the WHO Access, Watch, Reserve (AWaRe) classification. Antibiotics, 10(9), 1098.

Garcia Reeves, A. B. (2019). Antimicrobial stewardship programs: implications for resistance rates & quality of care in hospitals.

González de Llano, D., Moreno-Arribas, M., & Bartolomé, B. (2021). Cranberry polyphenols and prevention against urinary tract infections: A brief review.

Gupta, E., Saxena, J., Kumar, S., Sharma, U., Rastogi, S., Srivastava, V. K., Kaushik, S., & Jyoti, A. (2023). Fast track diagnostic tools for clinical management of sepsis: paradigm shift from conventional to advanced methods. Diagnostics, 13(2), 277.

Isac, R., Basaca, D.-G., Olariu, I.-C., Stroescu, R. F., Ardelean, A.-M., Steflea, R. M., Gafencu, M., Chirita-Emandi, A., Bagiu, I. C., & Horhat, F. G. (2021). Antibiotic resistance patterns of uropathogens causing urinary tract infections in children with congenital anomalies of kidney and urinary tract. Children, 8(7), 585.

Izett‐Kay, M., Barker, K. L., McNiven, A., & Toye, F. (2022). Experiences of urinary tract infection: A systematic review and meta‐ethnography. Neurourology and Urodynamics, 41(3), 724-739.

Josephs-Spaulding, J., Krogh, T. J., Rettig, H. C., Lyng, M., Chkonia, M., Waschina, S., Graspeuntner, S., Rupp, J., Møller-Jensen, J., & Kaleta, C. (2021). Recurrent urinary tract infections: unraveling the complicated environment of uncomplicated rUTIs. Frontiers in cellular and infection microbiology, 11, 562525.

Kebede, T. M. (2023). Anti-Bacterial Use and Resistance Pattern in Urinary Tract Infections. In Urinary Tract Infections-New Insights. IntechOpen.

Khoshnood, S., Heidary, M., Mirnejad, R., Bahramian, A., Sedighi, M., & Mirzaei, H. (2017). Drug-resistant gram-negative uropathogens: A review. Biomedicine & Pharmacotherapy, 94, 982-994.

Klein, R. D., & Hultgren, S. J. (2020). Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies. Nature Reviews Microbiology, 18(4), 211-226.

Kumar, M., Sarma, D. K., Shubham, S., Kumawat, M., Verma, V., Nina, P. B., Jp, D., Kumar, S., Singh, B., & Tiwari, R. R. (2021). Futuristic non-antibiotic therapies to combat antibiotic resistance: A review. Frontiers in microbiology, 12, 609459.

Lund, D. M. (2017). Effect of Continuing Education on Reduction of Urinary Tract Infection The College of St. Scholastica].

Machowska, A., & Stålsby Lundborg, C. (2019). Drivers of irrational use of antibiotics in Europe. International journal of environmental research and public health, 16(1), 27.

Mohiuddin, A. K., & Nasirullah, M. (2019). UTI prevalence among population with chronic conditions. Journal of Medical Research and Case Reports, 1(2).

Murgia, L. (2020). Development of a new medical device for the diagnosis and management of Urinary Tract Infections (UTIs).

Murugaiyan, J., Kumar, P. A., Rao, G. S., Iskandar, K., Hawser, S., Hays, J. P., Mohsen, Y., Adukkadukkam, S., Awuah, W. A., & Jose, R. A. M. (2022). Progress in alternative strategies to combat antimicrobial resistance: Focus on antibiotics. Antibiotics, 11(2), 200.

Pinkerton, J. V. (2020). Hormone therapy for postmenopausal women. New England Journal of Medicine, 382(5), 446-455.

Sayegh, N., Hallit, S., Hallit, R., Saleh, N., & Zeidan, R. K. (2021). Physicians' attitudes on the implementation of an antimicrobial stewardship program in Lebanese hospitals. Pharmacy Practice (Granada), 19(1).

Shin, D. J., Andini, N., Hsieh, K., Yang, S., & Wang, T.-H. (2019). Emerging analytical techniques for rapid pathogen identification and susceptibility testing. Annual review of analytical chemistry, 12, 41-67.

Von Vietinghoff, S., Shevchuk, O., Dobrindt, U., Engel, D. R., Jorch, S. K., Kurts, C., Miethke, T., & Wagenlehner, F. (2024). The global burden of antimicrobial resistance–urinary tract infections. Nephrology Dialysis Transplantation, 39(4), 581-588.

Wagenlehner, F., Nicolle, L., Bartoletti, R., Gales, A. C., Grigoryan, L., Huang, H., Hooton, T., Lopardo, G., Naber, K., & Poojary, A. (2022). A global perspective on improving patient care in uncomplicated urinary tract infection: expert consensus and practical guidance. Journal of global antimicrobial resistance, 28, 18-29.

Wall, S. (2019). Prevention of antibiotic resistance–an epidemiological scoping review to identify research categories and knowledge gaps. Global Health Action, 12(sup1), 1756191.