Tailoring antidepressant therapy based on genetic profiles
Review
Keywords:
Major depressive illness, Antidepressant drugs, Genetics, Precision medicineAbstract
Background: Depression is a substantial public health concern that impacts millions of individuals globally. The wide range of symptoms and manifestations of depression emphasizes the need of tailoring treatment methods to each individual, which includes adapting antidepressant prescriptions accordingly. Genetic factors contribute to depression and its association with other psychiatric and non-psychiatric illnesses, highlighting the need of a thorough assessment that encompasses psychopathology, physical health, and genetic variables. Aim of Work: This research aims to highlight the significance of customized therapy in the management of depression, taking into account hereditary variables, metabolic abnormalities, and inflammatory indicators. The research also seeks to emphasize the potential use of genotyping in directing the selection of antidepressants and making dose changes for people with altered metabolism. Methods: The research entails examining previously published works on the genetic factors related to depression, the influence of inflammatory and metabolic abnormalities in its development, and the possible advantages of genotyping in the treatment of antidepressants. The research also examines the incorporation of genetic information, such as the tendency to develop cardio-metabolic illnesses due to several genes, together with non-genetic risk factors to improve treatment results.
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