Characterization of skin tumors in an Egyptian large tertiary center

A cross-section study

https://doi.org/10.53730/ijhs.v8nS1.14936

Authors

  • Mohamed El-Khalawany Department of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, 11651, Egypt
  • Mohammad Moheb Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Modern University For Technology and Infor-mation (MTI), Cairo, Egypt
  • Mofreh Mansour Department of Dermatology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt
  • Omar AbdelHady Omar Ahmed Department of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, 11651, Egypt
  • Sameh Fahmy Mohamed Department of Dermatology and Venerology, Faculty of Medicine, Al-Azhar University, Cairo, 11651, Egypt
  • Ahmad Saeed Aladl Department of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, 11651, Egypt
  • Mohamed Amer Department of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, 11651, Egypt
  • Emad El Rewiny Department of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, 11651, Egypt
  • Manar Elsayed Sallam Department of Dermatology, Andrology and STDs, Faculty of Medicine, Mansoura University, Mansoura, 35516 , Egypt
  • Salma S Mohammed Department of Dermatology, Alzahra Hospital, Al-Azhar University, Cairo, Egypt
  • Ahmed Shawky Department of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, 11651, Egypt

Keywords:

skin tumor, basal cell carcinoma, melanoma, ultraviolet

Abstract

Skin tumors are a global health problem caused by UV exposure with ethnic and geographical distribution. This research summarized Egyptian skin tumor features. A cross-sectional study was conducted in the Al-Hussein Teaching Hospital, Al-Azhar University, Cairo, Egypt. Patients’ data were collected from the hospital-recorded registry from January 2010 to December 2020. Results: The age group, 19-59y, showed the highest prevalence, 57% (n=940), of skin tumors. The total number of skin tumor patients was 1649 (males 52.9% (n=872), females 47.1% (n=777). For benign skin tumors, the male-to-female ratio was 1: 0.96, and for malignant skin tumors, the male-to-female ratio was 1: 1.47. The frequency of skin tumors at the sun-exposed site (out of the total n= 1770) was 39.4% (n= 697) and the face showed the highest frequency 25.8% (n=457). The frequency of skin tumors at the non-sun-exposed sites was 60.6% (n=1073) of the total skin tumor number. Basal cell carcinoma (BCC) showed a frequency of 90.1% of cases affecting sun-exposed sites. Therefore, skin tumors have unique characteristics in Egypt, with malignant skin tumors being rare showing more predilection in males. Further studies are needed to emphasize the national characteristics of skin tumors in Egypt.

Downloads

Download data is not yet available.

References

AlSalman, S. A., Alkaff, T. M., Alzaid, T., & Binamer, Y. (2018). Nonmelanoma skin cancer in Saudi Arabia: Single center experience. Annals of Saudi Medicine, 38(1), 42–45. https://doi.org/10.5144/0256-4947.2018.21.01.1515

Arnold, M., Singh, D., Laversanne, M., Vignat, J., Vaccarella, S., Meheus, F., Cust, A. E., de Vries, E., Whiteman, D. C., & Bray, F. (2022). Global Burden of Cutaneous Melanoma in 2020 and Projections to 2040. JAMA Dermatology, 158(5), 495–503. https://doi.org/10.1001/jamadermatol.2022.0160

Basurto‐Lozada, P., Molina‐Aguilar, C., Castaneda‐Garcia, C., Vázquez‐Cruz, M. E., Garcia‐Salinas, O. I., Álvarez‐Cano, A., Martínez‐Said, H., Roldán‐Marín, R., Adams, D. J., Possik, P. A., & Robles‐Espinoza, C. D. (2021). Acral lentigi-nous melanoma: Basic facts, biological characteristics and research perspectives of an understudied disease. Pig-ment Cell & Melanoma Research, 34(1), 59–71. https://doi.org/10.1111/pcmr.12885

Bhatt, K., Tambe, S., Jerajani, H., & Dhurat, R. (2017). Utility of high-frequency ultrasonography in the diagnosis of benign and malignant skin tumors. Indian Journal of Dermatology, Venereology, and Leprology, 83(2), 162. https://doi.org/10.4103/0378-6323.191136

Bolick, N. L., & Geller, A. C. (2021). Epidemiology of Melanoma. Hematology/Oncology Clinics of North America, 35(1), 57–72. https://doi.org/10.1016/j.hoc.2020.08.011

Brenner, M., & Hearing, V. J. (2008). The Protective Role of Melanin Against UV Damage in Human Skin. Photochemistry and Photobiology, 84(3), 539–549. https://doi.org/10.1111/j.1751-1097.2007.00226.x

Burgard, B., & Reichrath, J. (2020a). Solarium Use and Risk for Malignant Melanoma: Many Open Questions, Not the Time to Close the Debate. Advances in Experimental Medicine and Biology, 1268, 155–170. https://doi.org/10.1007/978-3-030-46227-7_8

Burgard, B., & Reichrath, J. (2020b). Solarium Use and Risk for Malignant Melanoma: Many Open Questions, Not the Time to Close the Debate. Advances in Experimental Medicine and Biology, 1268, 155–170. https://doi.org/10.1007/978-3-030-46227-7_8

Dika, E., Scarfì, F., Ferracin, M., Broseghini, E., Marcelli, E., Bortolani, B., Campione, E., Riefolo, M., Ricci, C., & Lamber-tini, M. (2020). Basal Cell Carcinoma: A Comprehensive Review. International Journal of Molecular Sciences, 21(15), 5572. https://doi.org/10.3390/ijms21155572

El-Khalawany, M., Hassab-El-Naby, H. M. M., Mousa, A. M., Sameh, A., Rageh, M. A., Genedy, R. M., Hosny, A. M., Aboelmagd, M. A., & Aboeldahab, S. (2023). Epidemiological and clinicopathological analysis of basal cell carci-noma in Egyptian population: A 5-year retrospective multicenter study. Journal of Cancer Research and Clinical Oncology, 149(7), 3121–3129. https://doi.org/10.1007/s00432-022-04207-7

Garbe, C., & Leiter, U. (2009). Melanoma epidemiology and trends. Clinics in Dermatology, 27(1), 3–9. https://doi.org/10.1016/j.clindermatol.2008.09.001

Gruber, P., & Zito, P. M. (2023). Skin Cancer. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK441949/

Gupta, A. K., Bharadwaj, M., & Mehrotra, R. (2016). Skin Cancer Concerns in People of Color: Risk Factors and Prevention. Asian Pacific Journal of Cancer Prevention : APJCP, 17(12), 5257–5264. https://doi.org/10.22034/APJCP.2016.17.12.5257

Higgins, S., Nazemi, A., Chow, M., & Wysong, A. (2018). Review of Nonmelanoma Skin Cancer in African Americans, Hispanics, and Asians. DERMATOLOGIC SURGERY, 44(7), 903–910. https://doi.org/10.1097/DSS.0000000000001547

Hubner, J., Eisemann, N., Brunssen, A., & Katalinic, A. (2018). Skin cancer screening in Germany: Review after ten years. BUNDESGESUNDHEITSBLATT-GESUNDHEITSFORSCHUNG-GESUNDHEITSSCHUTZ, 61(12), 1536–1543. https://doi.org/10.1007/s00103-018-2836-6

Hussein, M. R. (2005). Skin cancer in Egypt: A word in your ear. Cancer Biology & Therapy, 4(5), 593–595. https://doi.org/10.4161/cbt.4.5.1730

Katalinic, A., Kunze, U., & Schafer, T. (2003). Epidemiology of cutaneous melanoma and non-melanoma skin cancer in Schleswig-Holstein, Germany: Incidence, clinical subtypes, tumour stages and localization (epidemiology of skin cancer). British Journal of Dermatology, 149(6), 1200–1206. https://doi.org/10.1111/j.1365-2133.2003.05554.x

Khandpur, S., & Ramam, M. (2012). Skin tumours. Journal of Cutaneous and Aesthetic Surgery, 5(3), 159. https://doi.org/10.4103/0974-2077.101368

Koczkodaj, P., Sulkowska, U., Didkowska, J., Rutkowski, P., & Mańczuk, M. (2023). Melanoma Mortality Trends in 28 Eu-ropean Countries: A Retrospective Analysis for the Years 1960–2020. Cancers, 15(5), 1514. https://doi.org/10.3390/cancers15051514

Leiter, U., Keim, U., & Garbe, C. (2020). Epidemiology of Skin Cancer: Update 2019. In J. Reichrath (Ed.), Sunlight, Vita-min D and Skin Cancer (Vol. 1268, pp. 123–139). Springer International Publishing. https://doi.org/10.1007/978-3-030-46227-7_6

Lembo, F., Cecchino, L. R., Parisi, D., & Portincasa, A. (2020). Utility of a New Artificial Dermis as a Successful Tool in Face and Scalp Reconstruction for Skin Cancer: Analysis of the Efficacy, Safety, and Aesthetic Outcomes. Der-matology Research and Practice, 2020, 4874035. https://doi.org/10.1155/2020/4874035

Lembo, F., Cecchino, L. R., Parisi, D., & Portincasa, A. (2022). Nonmelanoma Skin Cancer in COVID-19 Era: The Foggia Experience. Journal of Cutaneous and Aesthetic Surgery, 15(4), 436–438. https://doi.org/10.4103/JCAS.JCAS_84_21

Li, Z., Fang, Y., Chen, H., Zhang, T., Yin, X., Man, J., Yang, X., & Lu, M. (2022). Spatiotemporal trends of the global burden of melanoma in 204 countries and territories from 1990 to 2019: Results from the 2019 global burden of disease study. Neoplasia, 24(1), 12–21. https://doi.org/10.1016/j.neo.2021.11.013

Liu, F., Grimsrud, T. K., Veierød, M. B., Robsahm, T. E., Ghiasvand, R., Babigumira, R., Shala, N. K., & Stenehjem, J. S. (2021). Ultraviolet radiation and risk of cutaneous melanoma and squamous cell carcinoma in males and females in the Norwegian Offshore Petroleum Workers cohort. American Journal of Industrial Medicine, 64(6), 496–510. https://doi.org/10.1002/ajim.23240

Loh, T. Y., Ortiz, A., Goldenberg, A., & Brian Jiang, S. I. (2016). Prevalence and Clinical Characteristics of Nonmelanoma Skin Cancers Among Hispanic and Asian Patients Compared With White Patients in the United States: A 5-Year, Single-Institution Retrospective Review. Dermatologic Surgery, 42(5), 639–645. https://doi.org/10.1097/DSS.0000000000000694

Macneal, P., & Patel, B. C. (2023). Congenital Melanocytic Nevi. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK563168/

Myers, D. J., & Fillman, E. P. (2023). Dermatofibroma. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK470538/

Myroshnychenko, M. S., Moiseienko, T. M., Torianyk, I. I., Ivannik, V. Y., Popova, N. G., Mozhaiev, I. V., Chastii, T. V., Minukhin, V. V., Leontiev, P. A., Osolodchenko, T. P., & Parkhomenko, K. Y. (2022). SEBORRHEIC KERATOSIS: CURRENT STATE OF THE PROBLEM. Wiadomosci Lekarskie (Warsaw, Poland: 1960), 75(1 pt 2), 172–175.

Narayanan, D. L., Saladi, R. N., & Fox, J. L. (2010). Review: Ultraviolet radiation and skin cancer: UVR and skin cancer. International Journal of Dermatology, 49(9), 978–986. https://doi.org/10.1111/j.1365-4632.2010.04474.x

Nazer, R., Bashihab, R., Al-Madani, W., Omair, A., & AlJasser, M. (2020). Cherry angioma: A case–control study. Journal of Family and Community Medicine, 27(2), 109. https://doi.org/10.4103/jfcm.JFCM_293_19

Paulo, M. S., Adam, B., Akagwu, C., Akparibo, I., Al-Rifai, R. H., Bazrafshan, S., Gobba, F., Green, A. C., Ivanov, I., Kezic, S., Leppink, N., Loney, T., Modenese, A., Pega, F., Peters, C. E., Prüss-Üstün, A. M., Tenkate, T., Ujita, Y., Wittlich, M., & John, S. M. (2019). WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to solar ultraviolet radiation and of the effect of occupational exposure to solar ultraviolet radiation on melanoma and non-melanoma skin cancer. Environment International, 126, 804–815. https://doi.org/10.1016/j.envint.2018.09.039

Reichrath, J., Lindqvist, P. G., Pilz, S., März, W., Grant, W. B., Holick, M. F., & De Gruijl, F. R. (2020). Sunbeds and Mela-noma Risk: Many Open Questions, Not Yet Time to Close the Debate. Anticancer Research, 40(1), 501–509. https://doi.org/10.21873/anticanres.13978

Rogers, H. W., Weinstock, M. A., Feldman, S. R., & Coldiron, B. M. (2015). Incidence Estimate of Nonmelanoma Skin Can-cer (Keratinocyte Carcinomas) in the US Population, 2012. JAMA Dermatology, 151(10), 1081. https://doi.org/10.1001/jamadermatol.2015.1187

Roland, N., & Memon, A. (2023). Non-melanoma skin cancer of the head and neck. British Journal of Hospital Medicine (London, England: 2005), 84(4), 1–10. https://doi.org/10.12968/hmed.2021.0126

Rubin, R. (2020). Melanoma Diagnoses Rise While Mortality Stays Fairly Flat, Raising Concerns About Overdiagnosis. JAMA, 323(15), 1429. https://doi.org/10.1001/jama.2020.2669

Schadendorf, D., Fisher, D. E., Garbe, C., Gershenwald, J. E., Grob, J.-J., Halpern, A., Herlyn, M., Marchetti, M. A., McAr-thur, G., Ribas, A., Roesch, A., & Hauschild, A. (2015). Melanoma. Nature Reviews Disease Primers, 1(1), 15003. https://doi.org/10.1038/nrdp.2015.3

Shrivastava, V., Tangde, A., Joshi, A., & Bindu, R. (2019). Clinicopathological study of skin tumours. International Journal of Research in Medical Sciences, 7(5), 1712. https://doi.org/10.18203/2320-6012.ijrms20191664

Sinikumpu, S.-P., Huilaja, L., Jokelainen, J., Koiranen, M., Auvinen, J., Hägg, P. M., Wikström, E., Timonen, M., & Tasanen, K. (2014). High Prevalence of Skin Diseases and Need for Treatment in a Middle-Aged Population. A Northern Finland Birth Cohort 1966 Study. PLoS ONE, 9(6), e99533. https://doi.org/10.1371/journal.pone.0099533

Slominski, R. M., Sarna, T., Płonka, P. M., Raman, C., Brożyna, A. A., & Slominski, A. T. (2022a). Melanoma, Melanin, and Melanogenesis: The Yin and Yang Relationship. Frontiers in Oncology, 12, 842496. https://doi.org/10.3389/fonc.2022.842496

Slominski, R. M., Sarna, T., Płonka, P. M., Raman, C., Brożyna, A. A., & Slominski, A. T. (2022b). Melanoma, Melanin, and Melanogenesis: The Yin and Yang Relationship. Frontiers in Oncology, 12, 842496. https://doi.org/10.3389/fonc.2022.842496

Sorahan, T. (2007). Mortality of UK oil refinery and petroleum distribution workers, 1951-2003. Occupational Medicine, 57(3), 177–185. https://doi.org/10.1093/occmed/kql168

Stenehjem, J. S., Babigumira, R., Hosgood, H. D., Veierød, M. B., Samuelsen, S. O., Bråtveit, M., Kirkeleit, J., Rothman, N., Lan, Q., Silverman, D. T., Friesen, M. C., Robsahm, T. E., Kjærheim, K., Andreassen, B. K., Shala, N. K., Liu, F.-C., Strand, L.-Å., & Grimsrud, T. K. (2021). Cohort Profile: Norwegian Offshore Petroleum Workers (NOPW) Cohort. International Journal of Epidemiology, 50(2), 398–399. https://doi.org/10.1093/ije/dyaa107

Teng, Y., Yu, Y., Li, S., Huang, Y., Xu, D., Tao, X., & Fan, Y. (2021). Ultraviolet Radiation and Basal Cell Carcinoma: An Environmental Perspective. Frontiers in Public Health, 9, 666528. https://doi.org/10.3389/fpubh.2021.666528

Thapa, S., Ghosh, A., Ghartimagar, D., & Regmi, S. (2021). Benign Skin Neoplasms among the Histopathological Specimens of Skin Neoplasm in a Teaching Hospital: A Descriptive Cross-sectional Study. Journal of Nepal Medical Associa-tion, 59(243), 1106–1110. https://doi.org/10.31729/jnma.6086

Thawabteh, A. M., Jibreen, A., Karaman, D., Thawabteh, A., & Karaman, R. (2023). Skin Pigmentation Types, Causes and Treatment—A Review. Molecules, 28(12), 4839. https://doi.org/10.3390/molecules28124839

Tukenmez Demirci, G., Atis, G., Kivanc Altunay, I., & Sakiz, D. (2015). The Epidemiology of Non-Melanocytic Benign and Malignant Skin Tumors in Pediatric Patients Attending to the Dermatology Department. Journal of Clinical Medi-cine Research, 7(10), 770–774. https://doi.org/10.14740/jocmr2190w

Urban, K., Mehrmal, S., Uppal, P., Giesey, R. L., & Delost, G. R. (2021). The global burden of skin cancer: A longitudinal analysis from the Global Burden of Disease Study, 1990–2017. JAAD International, 2, 98–108. https://doi.org/10.1016/j.jdin.2020.10.013

Published

09-06-2024

How to Cite

El-Khalawany, M., Moheb, M., Mansour, M., Ahmed, O. A. O., Mohamed, S. F., Aladl, A. S., Amer, M., El Rewiny, E., Sallam, M. E., Mohammed, S. S., & Shawky, A. (2024). Characterization of skin tumors in an Egyptian large tertiary center: A cross-section study. International Journal of Health Sciences, 8(S1), 766–788. https://doi.org/10.53730/ijhs.v8nS1.14936

Issue

Vol. 8 No. S1 (2024)

Section

Peer Review Articles
Copyright & Licensing

Copyright (c) 2024 International journal of health sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.

Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.

This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.

Crossref
Scopus
Google Scholar
Europe PMC

Most read articles by the same author(s)