Correlation between levels of LGR-5 (leucine rich repeat containing protein coupled receptor 5) with clinical aspects and colorectal carcinoma stage

Mendila P Arungpadang; Ronald E Lusikooy; Firdaus Kasim; Mappincara Mappincara; Warsinggih Warsinggih

doi:10.53730/ijhs.v5n3.1541

Authors

Mendila P Arungpadang
mendilascorpio@gmail.com
Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Ronald E Lusikooy Digestive Surgery Division, Department of Surgery, Hasanuddin University, Makassar, Indonesia
Firdaus Kasim Department of Public Health, Hasanuddin University, Makassar, Indonesia
Mappincara Digestive Surgery Division, Department of Surgery, Hasanuddin University, Makassar, Indonesia
Warsinggih Digestive Surgery Division, Department of Surgery, Hasanuddin University, Makassar, Indonesia

Keywords:

cancer metastasis, clinical aspects, colorectal cancer, colorectal carcinoma stage, LGR-5 level, medical aid

Abstract

This study analyzes the colorectal cancer refers to gradually growing cancer that begins as tumor or tissue development in the internal layer of the rectum or stomach. CRC is resistant to chemotherapy and radiation and can cause collapse. This study is an analytical observational study using a cross-sectional study design with an evaluation stage of increasing LGR-5 levels on clinical aspects and stages of Colorectal Carcinoma patients in Makassar. Data collection was primary, where the data taken was demographic data and related to clinical aspects of the patient, namely, age, gender, cancer location, and cancer stage, lymph node participation, histopathological type when the patient came to treatment with diagnosis of colorectal cancer. The non-sanskari analysis was carried out on variables from the results of the study using contradiction analysis to determine the relationship between the increased level of LGR-5 and the stage of carcinogen ma patients based on AJCC. The analysis was carried out with the chi-square test. The value of significance is obtained when p <0.05.

Downloads

Download data is not yet available.

References

Amori, N., Aghajani, M., Asgarian, F. S., & Jazayeri, M. (2017). Epidemiology and trend of common cancers in Iran (2004–2008). European journal of cancer care, 26(5), e12449.

Baena, R., & Salinas, P. (2015). Diet and colorectal cancer. Maturitas, 80(3), 258-264.

Barker, N., & Clevers, H. (2010). Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells. Gastroenterology, 138(5), 1681-1696. https://doi.org/10.1053/j.gastro.2010.03.002

Barker, N., Van Es, J. H., Kuipers, J., Kujala, P., Van Den Born, M., Cozijnsen, M., ... & Clevers, H. (2007). Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature, 449(7165), 1003-1007.

Beckmann, K. R., Bennett, A., Young, G. P., Cole, S. R., Joshi, R., Adams, J., ... & Roder, D. (2015). Sociodemographic disparities in survival from colorectal cancer in South Australia: a population-wide data linkage study. BMC health services research, 16(1), 1-14.

Biswas, S. K., Allavena, P., & Mantovani, A. (2013, September). Tumor-associated macrophages: functional diversity, clinical significance, and open questions. In Seminars in immunopathology (Vol. 35, No. 5, pp. 585-600). Springer Berlin Heidelberg.

Bollati, V., & Baccarelli, A. (2010). Environmental epigenetics. Heredity, 105(1), 105-112.

Bratt, O. (2002). Hereditary prostate cancer: clinical aspects. The Journal of urology, 168(3), 906-913. https://doi.org/10.1016/S0022-5347(05)64541-7

Carchi, J. A. Y. ., Catagua, T. C. M. ., Rivera, D. G. B. ., Mera, V. B. ., & Rosario, M. del . (2021). From beginner to expert, experience of the rotating nursing intern in pre-professional practice. International Journal of Health Sciences, 5(2), 111-117.

Christensen, B. C., Houseman, E. A., Marsit, C. J., Zheng, S., Wrensch, M. R., Wiemels, J. L., ... & Kelsey, K. T. (2009). Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS genetics, 5(8), e1000602.

Dharmayuda, T. G., Suega, K., Bakta, I. M., & Sumohadi, I. M. D. (2021). Ki67 expression and prognostic aspects of colorectal cancer. International Journal of Health Sciences, 5(2), 79-88.

Fadaka, A. O., Pretorius, A., & Klein, A. (2019). Biomarkers for stratification in colorectal cancer: microRNAs. Cancer Control, 26(1), 1073274819862784.

Fatemi, S. R., Pourhoseingholi, M. A., Asadi, F., Vahedi, M., Pasha, S., Alizadeh, L., & Zali, M. R. (2015). Recurrence and five-year survival in colorectal cancer patients after surgery. Iranian journal of cancer prevention, 8(4).

Fukuma, M., Tanese, K., Effendi, K., Yamazaki, K., Masugi, Y., Suda, M., & Sakamoto, M. (2013). Leucine-rich repeat-containing G protein-coupled receptor 5 regulates epithelial cell phenotype and survival of hepatocellular carcinoma cells. Experimental cell research, 319(3), 113-121. https://doi.org/10.1016/j.yexcr.2012.10.011

Globocan 2018. (2018). World Health Organization. Global Health Observatory.

Gzil, A., Zar?bska, I., Jaworski, D., Antosik, P., Dur?lewicz, J., Maciejewska, J., ... & Szylberg, ?. (2020). The prognostic value of leucine-rich repeat-containing G-protein (Lgr5) and its impact on clinicopathological features of colorectal cancer. Journal of Cancer Research and Clinical Oncology, 146(10), 2547-2557.

Heinen, C. D. (2010). Genotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 693(1-2), 32-45. https://doi.org/10.1016/j.mrfmmm.2009.09.004

Huang, T., Qiu, X., Xiao, J., Wang, Q., Wang, Y., Zhang, Y., & Bai, D. (2016). The prognostic role of Leucine-rich repeat-containing G-protein-coupled receptor 5 in gastric cancer: A systematic review with meta-analysis. Clinics and research in hepatology and gastroenterology, 40(2), 246-253. https://doi.org/10.1016/j.clinre.2015.07.009

Ihemelandu, C., Naeem, A., Parasido, E., Berry, D., Chaldekas, K., Harris, B. T., ... & Albanese, C. (2019). Clinicopathologic and prognostic significance of LGR5, a cancer stem cell marker in patients with colorectal cancer. Colorectal cancer, 8(4), CRC11.

Jiang, Y., Li, W., He, X., Zhang, H., Jiang, F., & Chen, Z. (2016). Lgr5 expression is a valuable prognostic factor for colorectal cancer: evidence from a meta-analysis. BMC cancer, 16(1), 1-9.

Kazama, S., Kishikawa, J., Kiyomatsu, T., Kawai, K., Nozawa, H., Ishihara, S., & Watanabe, T. (2018). Expression of the stem cell marker CD133 is related to tumor development in colorectal carcinogenesis. Asian journal of surgery, 41(3), 274-278.

KJ, W. (1977). New Hope For Breastcancer Patients. InPharma, 7.

Kuipers, E. J., Grady, W. M., Lieberman, D., Seufferlein, T., Sung, J. J., & Boelens, P. G. (2015). Nat Rev Dis Primers. V1, DOI, 10.

Leushacke, M., & Barker, N. (2012). Lgr5 and Lgr6 as markers to study adult stem cell roles in self-renewal and cancer. Oncogene, 31(25), 3009-3022.

Lewis, C. E., Harney, A. S., & Pollard, J. W. (2016). The multifaceted role of perivascular macrophages in tumors. Cancer cell, 30(1), 18-25.

Matano, M., Date, S., Shimokawa, M., Takano, A., Fujii, M., Ohta, Y., ... & Sato, T. (2015). Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids. Nature medicine, 21(3), 256-262.

McCubrey, J. A., Abrams, S. L., Stadelman, K., Chappell, W. H., LaHair, M., Franklin, R. F., & Steelman, L. S. (2010). Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells. Advances in enzyme regulation, 50(1), 285.

Nakata, S., Phillips, E., & Goidts, V. (2014). Emerging role for leucine-rich repeat-containing G-protein-coupled receptors LGR5 and LGR4 in cancer stem cells. Cancer management and research, 6, 171.

Notoatmodjo, S. (2010). Ilmu perilaku kesehatan.

Öhman, U. (1982). Prognosis in patients with obstructing colorectal carcinoma. The American journal of surgery, 143(6), 742-747. https://doi.org/10.1016/0002-9610(82)90050-2

Raggi, C., Mousa, H. S., Correnti, M., Sica, A., & Invernizzi, P. (2016). Cancer stem cells and tumor-associated macrophages: a roadmap for multitargeting strategies. Oncogene, 35(6), 671-682.

Rawla, P., Sunkara, T., & Barsouk, A. (2018). Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol. 2019; 14 (2): 89–103.

Rhee, Y. Y., Kim, K. J., & Kang, G. H. (2017). CpG island methylator phenotype-high colorectal cancers and their prognostic implications and relationships with the serrated neoplasia pathway. Gut and liver, 11(1), 38.

Schepers, A. G., Snippert, H. J., Stange, D. E., van den Born, M., van Es, J. H., van de Wetering, M., & Clevers, H. (2012). Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science, 337(6095), 730-735.

Shekarriz, R., Montazer, F., & Alizadeh-Navaei, R. (2019). Overexpression of cancer stem cell marker Lgr5 in colorectal cancer patients and association with clinicopathological findings. Caspian journal of internal medicine, 10(4), 412.

Siegel, R. L., Miller, K. D., Goding Sauer, A., Fedewa, S. A., Butterly, L. F., Anderson, J. C., ... & Jemal, A. (2020). Colorectal cancer statistics, 2020. CA: a cancer journal for clinicians, 70(3), 145-164.

Thoresen, L., Frykholm, G., Lydersen, S., Ulveland, H., Baracos, V., Prado, C. M., ... & Falkmer, U. (2013). Nutritional status, cachexia and survival in patients with advanced colorectal carcinoma. Different assessment criteria for nutritional status provide unequal results. Clinical nutrition, 32(1), 65-72. https://doi.org/10.1016/j.clnu.2012.05.009

Valastyan, S., & Weinberg, R. A. (2011). Tumor metastasis: molecular insights and evolving paradigms. Cell, 147(2), 275-292. https://doi.org/10.1016/j.cell.2011.09.024

Vitola, J. V., Delbeke, D., Sandler, M. P., Campbell, M. G., Powers, T. A., Wright, J. K., ... & Pinson, C. W. (1996). Positron emission tomography to stage suspected metastatic colorectal carcinoma to the liver. The American journal of surgery, 171(1), 21-26. https://doi.org/10.1016/S0002-9610(99)80067-1

Wang, H., Chen, Y., Fernandez-Del Castillo, C., Yilmaz, O., & Deshpande, V. (2013). Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway. Modern Pathology, 26(1), 139-147.

Widana, I.K., Sumetri, N.W., Sutapa, I.K., Suryasa, W. (2021). Anthropometric measures for better cardiovascular and musculoskeletal health. Computer Applications in Engineering Education, 29(3), 550–561. https://doi.org/10.1002/cae.22202

Winawer, S. J. (1999). Natural history of colorectal cancer. The American journal of medicine, 106(1), 3-6. https://doi.org/10.1016/S0002-9343(98)00338-6

Wu, X. S., Xi, H. Q., & Chen, L. (2012). Lgr5 is a potential marker of colorectal carcinoma stem cells that correlates with patient survival. World journal of surgical oncology, 10(1), 1-8.

Yuan, J., Yu, J. X., & Ge, J. (2010). Sexual dimorphism on the neurogenic potential of rhesus monkeys mesenchymal stem cells. Biochemical and biophysical research communications, 396(2), 394-400.

Zhang, Q. W., Liu, L., Gong, C. Y., Shi, H. S., Zeng, Y. H., Wang, X. Z., ... & Wei, Y. Q. (2012). Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature. PloS one, 7(12), e50946.

Zheng, Z., Yu, H., Huang, Q., Wu, H., Fu, Y., Shi, J., ... & Fan, X. (2018). Heterogeneous expression of Lgr5 as a risk factor for focal invasion and distant metastasis of colorectal carcinoma. Oncotarget, 9(53), 30025.

Ziskin, J. L., Dunlap, D., Yaylaoglu, M., Fodor, I. K., Forrest, W. F., Patel, R., ... & Jubb, A. M. (2013). In situ validation of an intestinal stem cell signature in colorectal cancer. Gut, 62(7), 1012-1023.