The role of pharmacogenomics in personalized medicine: A focus on drug metabolism

Ali Nasser Alsuwaileh; Ibrahim Abdulaziz Ibrahim Albakheet; Hammad Abdullah Aljaloud; Abdullah Khalifah Aljadeedi; Saeed Hassan Alyami; Abdulaziz Hussain Mohammed Alrashed

doi:10.53730/ijhs.v8nS1.15423

Authors

Ali Nasser Alsuwaileh KSA, National Guard Health Affairs
Ibrahim Abdulaziz Ibrahim Albakheet Albakheet- Public Health
Hammad Abdullah Aljaloud KSA, National Guard Health Affairs
Abdullah Khalifah Aljadeedi KSA, National Guard Health Affairs
Saeed Hassan Alyami KSA, National Guard Health Affairs
Abdulaziz Hussain Mohammed Alrashed National Guard Health Affairs

Keywords:

Pharmacokinetics, pharmacogenomics, gene-pharmacotherapy, genetic differences, side effects of drugs, pharmacogenomics analysis

Abstract

Background: The conventional model of drug treatment may involve set protocols of drug use and not the currently variegated pharmacology patterns due to mutations in drug metabolism enzymes. But recent innovations in pharmacogenomics have provided new insight on feeds and processing of drugs through genetic and environment components that present a more divergent view of treatment. Aim: The purpose of this study is to understand drug metabolism specificity in the framework of individualized medicine and its potential to enhance the efficacy and safety of a drug due to genetic and lifestyle differences. Methods: A literature search was performed to compare the effects of genetic variations and environment as to drug metabolism. The research also focuses at how the pharmacogenomics testing is used in developing the custom drug therapies. Results: major impact in the rate of metabolism of drugs along with their effectiveness and toxicity. Of course, assessing health-promoting behaviours that include diet and physical activity, or the lack of thereof, as well as others, can strongly impact therapeutic success. Conclusion: Potential for manufactured Meal is its ability to highlight the vests in drug metabolism that are crucial for finding personalized treatments.

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