Biochemical composition and therapeutic values of leaves of Lippia multiflora Moldenke grown in Côte d'Ivoire

https://doi.org/10.53730/ijhs.v9n2.15520

Authors

  • Fako Kané Nangui Abrogoua University, Abidjan, Côte d’Ivoire
  • Wohi Maniga Peleforo Gon Coulibaly University, Korhogo, Côte d’Ivoire
  • Mankambou Jacques Gnanwa Jean Lorougnon Guede University, Daloa, Côte d’Ivoire

Keywords:

biochemical composition, Côte d’Ivoire, leaves, Lippia multiflora, therapeutic value

Abstract

Phytochemical analysis of leaves from two varieties of Lippia multiflora cultivated in two localities of Côte d'Ivoire, such as Béoumi and Korhogo, were carried out to provide information on the therapeutic value of this herbal tea. Results showed the presence of bioactive compounds like alkaloids, tannins, and flavonoids in the extracts. All of the extracts were rich in condensed tannins. Concerning flavonoids, flavone was high grade in extracts from Béoumi, while the highest levels of flavanols were found in extracts from Korhogo. Essential minerals like calcium (Ca), sodium (Na), magnesium (Mg), potassium (K), phosphorus (P), manganese (Mn), zinc (Zn), copper (Cu), and iron (Fe) were present in leaves and extracts. In addition, the levels of both of these minerals in the extract were below the maximum level permissible suggested by the World Health Organization (1989). We also noted the variability of both components according to the cultivation areas. The presence of phytochemical components and mineral elements in the aqueous extracts of Lippia multiflora contributes to their therapeutic application in medicinal practices and their nutritional importance. However, the variability among the phytochemical profiles of samples from different areas expresses their different medicinal, pharmacologic, and nutritional properties.

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References

Abena, A. A., Diatewa, M., Gakosso, G., Gbeassor, M., Hondi-Assah, T. H., & Ouamba, J. M. (2003). Analgesic, antipyretic and anti-inflammatory effects of essential oil of Lippia multiflora. Fitoterapia, 74(3), 231-236. https://doi.org/10.1016/S0367-326X(03)00029-7 DOI: https://doi.org/10.1016/S0367-326X(03)00029-7

Adnan, M., Ahmad, A., Ahmed, A., Khalid, N., Hayat, I., & Ahmed, I. (2013). Chemical composition and sensory evaluation of tea (Camellia sinensis) commercialized in Pakistan. Pak. J. Bot, 45(3), 901-907.

Agnaniet, H., Makani, T., Akagah, A., Menut, C., & Bessière, J. M. (2005). Volatile constituents and antioxidant activity of essential oils from Lippia multiflora Mold. growing in Gabon. Flavour and fragrance journal, 20(1), 34-38. DOI: https://doi.org/10.1002/ffj.1383

Agrawal, A. D. (2011). Pharmacological activities of flavonoids: a review. Int. J. Pharm. Sci. Nanotechnol, 4(2), 1394-1398. DOI: https://doi.org/10.37285/ijpsn.2011.4.2.3

Aherne, S. A., & O’Brien, N. M. (2002). Dietary flavonols: chemistry, food content, and metabolism. Nutrition, 18(1), 75-81. https://doi.org/10.1016/S0899-9007(01)00695-5 DOI: https://doi.org/10.1016/S0899-9007(01)00695-5

Al-Fartusie, F. S., & Mohssan, S. N. (2017). Essential trace elements and their vital roles in human body. Indian J Adv Chem Sci, 5(3), 127-136.

Alphonse, A. K., Albert, Y. K., Célestin, B. K., Patrice, K. K., Antoine, N. G. K., & Yves, N. K. (2011). Comportement de deux morphotypes de Lippia multiflora (Verbenaceae) sur ferralsols de la région de Yamoussoukro, Côte d’Ivoire. Journal of Applied Biosciences, 38, 2592-2601.

Annan, K., Kojo, A. I., Cindy, A., Samuel, A. N., & Tunkumgnen, B. M. (2010). Profile of heavy metals in some medicinal plants from Ghana commonly used as components of herbal formulations. Pharmacognosy Research, 2(1), 41. DOI: https://doi.org/10.4103/0974-8490.60579

Ashok, P. K., & Upadhyaya, K. (2012). Tannins are astringent. Journal of pharmacognosy and phytochemistry, 1(3), 45-50.

Association of Analytical Chemists. Official Methods of Analysis. (2000). 17th ed., Arlington, Virginia. USA.

Donkora, A., Kuranchiea, C., Osei-Fosua, P., Nyarkoa, S., & Doamekpora, L. (2015). Assessment of essential minerals and toxic trace metals in popularly consumed tea products in Ghana, A Preliminary Study. Res J Chem Environ Sci, 3(1), 49-55.

Bangou, M. J., Kiendrebeogo, M., Compaoré, M., Coulibaly, A. Y., Meda, N. T. R., Abarca, N. A., ... & Nacoulma, O. G. (2011). Enzyme inhibition effect and polyphenolic content of medicinal plant extracts from Burkina Faso.

Bidie, A. P., N’guessan, B. B., Yapo, A. F., N’Guessan, J. D., & Djaman, A. J. (2011). Activités antioxydantes de dix plantes medicinales de la pharmacopée ivoirienne. Sciences & Nature, 8(1-2), 1-12.

Cherotich, L., Kamunya, S.M., Alakonya, A., Msomba, S.W., Uwimana, M.A., Wanyoko, J.K. & Owuor, P.O. (2013). Variation in catechin composition of popularly cultivated tea clones in east Africa (Kenya). American Journal of Plant Sciences, 4, 628-640. DOI: https://doi.org/10.4236/ajps.2013.43081

Coșarcă, S., Tanase, C., & Muntean, D. L. (2019). Therapeutic aspects of catechin and its derivatives–an update. Acta Biologica Marisiensis, 2(1), 21-29. DOI: https://doi.org/10.2478/abmj-2019-0003

Edet, R., Bello, O. I., & Babajide, J. (2019). Culture and the development of traditional medicine in Africa.

Germame, Y., & Mekuria, T. (2021). Identification of Bioactive Compound. Phytochemical Analysis and Antimicrobial Activity of Lippia adoensis var. koseret from Ethiopia. Sch Int J Tradit Complement Med, 4(8), 139-153.

Hossain, M. T., Furhatun-Noor, A., Matin, A., Tabassum, F., & Ar Rashid, H. (2021). A review study on the pharmacological effects and mechanism of action of tannins. European J. Pharm. Med. Res, 8(8), 5-10.

Ilyas, M., Arshad, M. U., Saeed, F., & Iqbal, M. (2015). Antioxidant potential and nutritional comparison of Moringa leaf and seed powders and their tea infusions. J. Anim. Plant Sci, 25(1), 226-233.

Irvine, F. N. (1961). Loranthaceae. Woody plants of Ghana with special reference to their uses.

Kanko, C., Koukoua, G., N'Guessan, Y. T., Fournier, J., Pradère, J. P., & Toupet, L. (2004). Contribution à l'étude phytochimique de Lippia multiflora (Verbenaceae). Comptes Rendus Chimie, 7(10-11), 1029-1032. https://doi.org/10.1016/j.crci.2003.12.028 DOI: https://doi.org/10.1016/j.crci.2003.12.028

Kunle, O., Okogun, J., Egamana, E., Emojevwe, E., & Shok, M. (2003). Antimicrobial activity of various extracts and carvacrol from Lippia multiflora leaf extract. Phytomedicine, 10(1), 59-61. https://doi.org/10.1078/094471103321648674 DOI: https://doi.org/10.1078/094471103321648674

Lahhob, Q.R., Al-sanaf, A.E., Mohammed, N.Y., Abbas, H.J., Ibrahim, Z.J., Najim, M.K., Malik, Z.A., Budaiwi, Z.K., Abdul-Jabbar, Z.H. & Kadhamk, M.J. (2023). Mineral and Trace Elements, Dietary Sources, Biological Effects, Deficiency, and Toxicity: A Review. Eurasian Chemical Communications, 5(6), 536-555.

Lesjak, M., Beara, I., Simin, N., Pintać, D., Majkić, T., Bekvalac, K., ... & Mimica-Dukić, N. (2018). Antioxidant and anti-inflammatory activities of quercetin and its derivatives. Journal of functional foods, 40, 68-75. https://doi.org/10.1016/j.jff.2017.10.047 DOI: https://doi.org/10.1016/j.jff.2017.10.047

Ma, W., Guo, A., Zhang, Y., Wang, H., Liu, Y., & Li, H. (2014). A review on astringency and bitterness perception of tannins in wine. Trends in Food Science & Technology, 40(1), 6-19. https://doi.org/10.1016/j.tifs.2014.08.001 DOI: https://doi.org/10.1016/j.tifs.2014.08.001

Magoma, G. N., Wachira, F. N., Obanda, M., Imbuga, M., & Agong, S. G. (2000). The use of catechins as biochemical markers in diversity studies of tea (Camellia sinensis). Genetic Resources and Crop Evolution, 47(2), 107-114. DOI: https://doi.org/10.1023/A:1008772902917

Mehansho, H., Butler, L. G., & Carlson, D. M. (1987). Dietary tannins and salivary proline-rich proteins: interactions, induction, and defense mechanisms. Annual review of nutrition, 7(1), 423-440. DOI: https://doi.org/10.1146/annurev.nutr.7.1.423

Mutuku, A., Wanyoko, J., Wachira, F., Kamunya, S., Chalo, R., Kimutai, S., ... & Karori, S. (2016). Influence of geographical regions on catechin and caffeine levels in tea (Camellia sinensis). American Journal of Plant Sciences, 7(3), 562-571. DOI: https://doi.org/10.4236/ajps.2016.73049

Ngaibi, J., Taiwe, G. S., Njapdounke, J. S. K., Nguezeye, Y., Sidiki, N., & Bum, E. N. (2021). Potential of an aqueous extract of Lippia multiflora Moldenke (Verbenaceae) in the treatment of anxiety disorders: Possible involvement of serotoninergic transmission. GSC Biological and Pharmaceutical Sciences, 14(3), 277-289. DOI: https://doi.org/10.30574/gscbps.2021.14.3.0079

Obouayeba, A. P., Diarrassouba, M., Soumahin, E. F., & Kouakou, T. H. (2015). Phytochemical analysis, purification and identification of Hibiscus anthocyanins. J Pharm Chem Biol Sci, 3(2), 156-168.

Okuda, T., & Ito, H. (2011). Tannins of constant structure in medicinal and food plants—hydrolyzable tannins and polyphenols related to tannins. Molecules, 16(3), 2191-2217. DOI: https://doi.org/10.3390/molecules16032191

Oladimeji, F. A., Orafidiya, O. O., Ogunniyi, T. A. B., & Adewunmi, T. A. (2000). Pediculocidal and scabicidal properties of Lippia multiflora essential oil. Journal of Ethnopharmacology, 72(1-2), 305-311. https://doi.org/10.1016/S0378-8741(00)00229-4 DOI: https://doi.org/10.1016/S0378-8741(00)00229-4

Olafisoye, O. B., Ojelade, O. D., & Osibote, O. A. (2017). Trace elements and antioxidants in some medicinal plants. Res Rev Biosci, 11(3), 111.

Osredkar, J., & Sustar, N. (2011). Copper and zinc, biological role and significance of copper/zinc imbalance. J Clinic Toxicol s, 3(2161), 0495. DOI: https://doi.org/10.4172/2161-0495.S3-001

Owuor, P. O., & Kwach, B. O. (2012). Quality and yields of black tea Camellia sinensis LO Kuntze in responses to harvesting in Kenya: a review. Asian Journal of Biological and Life Sciences, 1 (1) 1-7.

Pascual, M. E., Slowing, K., Carretero, E., Mata, D. S., & Villar, A. (2001). Lippia: traditional uses, chemistry and pharmacology: a review. Journal of ethnopharmacology, 76(3), 201-214. https://doi.org/10.1016/S0378-8741(01)00234-3 DOI: https://doi.org/10.1016/S0378-8741(01)00234-3

Plum, L. M., Rink, L., & Haase, H. (2010). The essential toxin: impact of zinc on human health. International journal of environmental research and public health, 7(4), 1342-1365. DOI: https://doi.org/10.3390/ijerph7041342

Rajput, A., Sharma, R., & Bharti, R. (2022). Pharmacological activities and toxicities of alkaloids on human health. Materials Today: Proceedings, 48, 1407-1415. https://doi.org/10.1016/j.matpr.2021.09.189 DOI: https://doi.org/10.1016/j.matpr.2021.09.189

Reddy, V. S., Shiva, S., Manikantan, S., & Ramakrishna, S. (2024). Pharmacology of caffeine and its effects on the human body. European Journal of Medicinal Chemistry Reports, 100138. https://doi.org/10.1016/j.ejmcr.2024.100138 DOI: https://doi.org/10.1016/j.ejmcr.2024.100138

Rehman, J. U., Aktar, N., Khan, M. Y., Ahmad, K., Ahmad, M., Sultana, S., & Asif, H. M. (2015). Phytochemical screening and hepatoprotective effect of Alhagi maurorum Boiss (Leguminosae) against paracetamol-induced hepatotoxicity in rabbits. Tropical Journal of Pharmaceutical Research, 14(6), 1029-1034. DOI: https://doi.org/10.4314/tjpr.v14i6.13

Shah, K. K., Verma, R., Oleske, J. M., Scolpino, A., & Bogden, J. D. (2019). Essential trace elements and progression and management of HIV infection. Nutrition Research, 71, 21-29. https://doi.org/10.1016/j.nutres.2019.08.001 DOI: https://doi.org/10.1016/j.nutres.2019.08.001

Singleton, V. L., Orthofer, R., & Lamuela-Raventós, R. M. (1999). [14] Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent. In Methods in enzymology (Vol. 299, pp. 152-178). Academic press. https://doi.org/10.1016/S0076-6879(99)99017-1 DOI: https://doi.org/10.1016/S0076-6879(99)99017-1

Sofowora, A. (1993). Medicinal plants and traditional medicine in Africa. Ibadan. Nigeria: Spectrum Books Ltd, 191-289.

Swarnalatha, G., Nath, B. S., Naik, N. L., Amaladhas, P. H., & Emerald, F. M. E. (2021). Therapeutic potential of green tea catechins-A magical herb. Int. J. Curr. Microbiol. App. Sci, 10(02), 3560-3571. DOI: https://doi.org/10.20546/ijcmas.2021.1002.392

Toyosi, D., Olu, M. & Alamu E. A. (2013). Preliminary antibacterial and phytochemical screening of three medicinal plants used in the folkloric treatment of skin infection. International Journal of Research in Ayurveda and Pharmacy, 4 (4), 547-550. DOI: https://doi.org/10.7897/2277-4343.04419

Valentin, A., Pélissier, Y., Benoit, F., Marion, C., Kone, D., Mallie, M., ... & Bessière, J. M. (1995). Composition and antimalarial activity in vitro of volatile components of Lippia multiflora. Phytochemistry, 40(5), 1439-1442. https://doi.org/10.1016/0031-9422(95)00522-9 DOI: https://doi.org/10.1016/0031-9422(95)00522-9

Wangrawa, D. W., Waongo, A., Traore, F., Sanou, D., Lahondere, C., Sané, A. R., ... & Sanon, A. (2024). The Essential Oils Compounds of Lippia multiflora Moldenke and Cymbopogon schoenanthus (L.) Spreng Repel and Affect the Survival of the Maize Pest Spodoptera frugiperda (Lepidoptera: Noctuidae) Larvae. Psyche: A Journal of Entomology, 2024(1), 1202962. DOI: https://doi.org/10.1155/2024/1202962

Wheeler, D. S., & Wheeler, W. J. (2004). The medicinal chemistry of tea. Drug development research, 61(2), 45-65. DOI: https://doi.org/10.1002/ddr.10341

Zeece, M. (2020). Introduction to the Chemistry of Food. Academic Press.

Published

04-05-2025

How to Cite

Kané, F., Maniga, W., & Gnanwa, M. J. (2025). Biochemical composition and therapeutic values of leaves of Lippia multiflora Moldenke grown in Côte d’Ivoire. International Journal of Health Sciences, 9(2), 325–336. https://doi.org/10.53730/ijhs.v9n2.15520

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Peer Review Articles