Study the role of GLP-1 receptor agonist (Liraglutide) on experimentally induced diabetic nephropathy in male albino rats

Samah Gamal Elsayed Elraey; Mohamed Mohamed Shebl; Ahmed Elsayed Abdelfattah; Sahar Ahmed Elsawy

doi:10.53730/ijhs.v9nS1.15674

Authors

Samah Gamal Elsayed Elraey
gamalsamah91@gmail.com
Physiology Department, Faculty of Medicine, Tanta University, Egypt
Mohamed Mohamed Shebl Physiology Department, Faculty of Medicine, Tanta University, Egypt
Ahmed Elsayed Abdelfattah Physiology Department, Faculty of Medicine, Tanta University, Egypt
Sahar Ahmed Elsawy Physiology Department, Faculty of Medicine, Tanta University, Egypt

Keywords:

caspase-12, Diabetic nehpropathy, FOXO1, Glucagon-like peptide 1, GRP78

Abstract

This study is to display glucagon-like peptide 1 (GLP-1) receptor agonist (liraglutide) role in diabetic nephropathy (DN) in rats and to investigate its mechanism of action. 60 male albino rats were divided into: I) control group; II) DN group; III) DN pre-treated group; IV) DN post-treated group. Group II, III & IV revealed a significant reduction in final body weight compared to control. Group II showed significant decreases in e-GFR, GSH and FoxO1 which were significantly elevated in group III & IV near to control. However, Group II showed significant rises in urinary protein, ACR, BUN, serum creatinine, TNFα, insulin, glucose, HOMA IR, MDA, caspase-12 and GRP78 that were significantly reduced in group III & IV near to control. FoxO1 has positive correlations with e-GFR and GSH and has negative correlations with urinary protein, ACR, BUN, serum creatinine, TNF-α, insulin, glucose, HOMA IR, MDA, caspase-12 and GRP78 in all groups. The histopathological findings of Group II showed glomeruli distortion and interstitial hemorrhage but group III & IV revealed enhancement in renal architecture. We can conclude that liraglutide has a significant role in the protection and treatment of the kidneys in DN.

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