Study of clinical profiles of tubercular meningitis patients with seizures

Abstract

Background: Tuberculosis remains a serious global health problem, with an estimated 10 million new cases occurring globally during 2019. CNS involvement one of the most devastating clinical manifestations of tuberculosis (TB) is noted in 5-10% of extrapulmonary TB cases, and accounts for approximately 1% of all TB cases and it also carries significant higher mortality and neurological disability among infected individuals especially in low income countries. Materials & Methods: It’s a hospital based prospective study which will include 80 patients admitted in department of Medicine and Neurology diagnosed as tubercular meningitis with a duration of 3 years. All Subjects were subjected to anthropometric measurements and routine biochemical tests – Hemogram, Urea, Serum Creatinine, LFT, Lipid Profile. Results: In patients who developed seizures before hospital admission, most common finding in neuroimaging is hydrocephalus, inflammatory edema and ventriculomegaly in patient who developed seizure within first week of hospital admission, majority had normal CT finding (27.27%) followed by metabolic cause like hyponatremia and hepatitis(18.18).In patients who developed seizure after 1^st week of hospital admission, commonest cause found is Hydrocephalus(25.69%) and tuberculoma (17.64%)  followed by calcified granuloma (15.68%).