The effect lanolin extract and vaseline with glycerine mixture to treatment by affecting of IL-4 and IL-13 level in induced eczema in rats
Keywords:
IL-4, IL-13, lanolin, vaseline, ratsAbstract
The goal of this study was to assess the healing effectiveness of lanoline (also known as wool waxes or wool grease), an oil compound released by skin sebaceous glands for sheep that possesses characteristics against microbial, inflammation, as well as protecting properties for skin. It also has an excellent moisturizing function. The determination of Interleukin-4 and Interleukin-13, it can be determined due to the accumulation of inflammatory cells in the affected area that signal the production of Interleukin-4 and Interleukin-13 in cases of eczema. Both the increase in IL-4 and IL-13, Reduces synthesis of essential structural proteins such as filaggrin and lipid components required for effective skin barrier activities, resulting in increased trans epidermal water loss, which is commonly observed and expected in eczema. The study showed a significant increase in the eczema and glycerine group for 24 hours for both IL-4 and IL-13, where there was a slight decrease in the 24-hour lanolin group compared to the control group as well as between groups.
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