Gene expression analysis of Aerva javanica and Parkinsonia aculeata synthesized gold nanoparticles in Cervical and Liver cancer cell lines
Keywords:
Aerva javanica, Parkinsonia aculeata, p53, HeLa, HepG2Abstract
Chemotherapy is effective in many cancer treatments compare to surgery and radiation. Due to its side effects and multidrug resistance, Nanoparticles synthesized from some of the medicinal plants are one of the prominent alternatives for the treatment of various diseases. In our present study, Synthesized the AuNPs from Aerva javanica and Parkinsonia aculeata extract and studied the p53, caspase-3, Caspase-9 and NF-kB gene expression in HeLa and HepG2 cell lines by Real-time PCR. p53 gene down regulation was observed in Aerva javanica AuNPs treated HeLa cells compared to HepG2 cells and caspase-3, Caspase-9 and NF-kB gene expression levels were not changed in both cell lines. Parkinsonia aculeata AuNPs treated HeLa and HepG2 cells not showed any changes in gene expression levels of studied genes. Based on the present results concluding the Aerva javanica AuNPs are effective anti-cancer activity on cervical cancer cells.
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