Determination of deferasirox (anti-thalassemia drug) in serum and urine: cyclic voltammetry study

Fatima Hamza M. Baker; Hiba Ali Numan; Muthana Saleh Mashkour

doi:10.53730/ijhs.v6nS1.5653

Authors

Fatima Hamza M. Baker
fatima.hamza@alkafeel.edu.iq
Al-Kafeel University, College of Health and Medical Technologies, Department of Medical Laboratory Technologies, Iraq
Hiba Ali Numan Al-Kafeel University, College of Health and Medical Technologies, Department of Medical Laboratory Technologies, Iraq
Muthana Saleh Mashkour Faculty of Science, Department of Chemistry, University of Kufa, Iraq

Keywords:

Electrochemistry, Cyclicvoltametery, Glassy carbon electrod, MWCNTs, Defeasirox and Thalassema

Abstract

The purpose of this project is to examine cyclic voltammetry (CV) analytical technique for anti_thalassemia drug of deferasirox by modified multi-walled carbon nanotubes (MWCNTs) on glassy carbon electrod (GCE) was described. The electrochemical performance of deferasirox was studied by cyclic voltammetry technique. The ability of the electrode for the determination of deferasirox under Optimize condition in pH 13.8~14, scan rate 100mv/s, temperature 30 ⁰C and interference that have been studied. Where found the results that calibration curve of deferasirox was linear in the concentrations 13.4×10^-4-2.6×10^-2 M, its detection limit was 8.46×10^-11M and LOQ was 2.82×10^-10 M. The enthalpy ∆H was calculated to be (6.736 kJ. mol^-1), and the entropy can be calculated to be (213.8 J. K^‐¹ mol^‐¹). The area of electrode was calculated to be 0.314 cm²and also the diffusion coefficient was 3.154×10^-4 cm²sec^-1. RSD% for bulk and form was less than 0.3% while serum and urine less than 2.5% and recovery in all close to 100.1%. The voltammogram for deferasirox give irreversible process with diffusion– controlled process. Finally, this technique has been applied for deferasirox on pharmaceutical formulations and biological samples (serum and urine).

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