Antiemetic effect of intravenous palonosetron and ondansetron for the prevention of postoperative nausea and vomiting following laparoscopic surgeries under general anaesthesia, a randomised observational study

Dinesh Chauhan; Tejash Sharma; Ganesh C. Naik

doi:10.53730/ijhs.v6nS2.5694

Antiemetic effect of intravenous palonosetron and ondansetron for the prevention of postoperative nausea and vomiting following laparoscopic surgeries under general anaesthesia, a randomised observational study

https://doi.org/10.53730/ijhs.v6nS2.5694

Authors

Dinesh Chauhan Professor and Head, Department of Anaesthesiology, Shrimati Bhikhiben Kanjibhai Shah, Medical Institute & Research Centre, Sumandeep Vidyapeeth (An Institute Deemed to be University), Piparia, Vadodara, Gujarat, India
Tejash Sharma Associate Professor, Department of Anaesthesiology, Shrimati Bhikhiben Kanjibhai Shah, Medical Institute & Research Centre, Sumandeep Vidyapeeth (An Institute Deemed to be University), Piparia, Vadodara, Gujarat, India
Ganesh C. Naik
ganeshnaik888@gmail.com
3rd year resident, Department of Anaesthesiology, Shrimati Bhikiben Kanjibhai Shah, Medical Institute & Research Centre, Sumandeep Vidyapeeth (An Institute Deemed to be University) Piparia, Vadodara, Gujarat, India

Keywords:

ondansetron, palonosetron, laparoscopic surgeries, general anaesthesia

Abstract

Post-operative nausea and vomiting(PONV) is one of the common complications in patients undergoing laparoscopic surgeries under general anaesthesia. This study compares efficacy of prophylactic palonosetron and ondansetron in the prevention of PONV. After obtaining the approval of institutional ethical committee, a prospective randomised study was conducted on 60 patients belonging to American Society of Anaesthesiologists Grade I and II, patients of either sex, aged between 18 to 60 years, fulfilling the inclusion criteria were divided into two groups receiving inj. ondansetron 8 milligrams i.v. or inj. palonosetron 75 micrograms i.v. Incidence of PONV and need of rescue antiemetic was recorded post operatively. Data were evaluated statistically using Graph Pad Prism computer software version 6.04.It was found that inj. palonosetron 75mcg i.v. was more efficient in the prevention of PONV and required lesser rescue antiemetic when compared inj. ondansetron 8mg i.v. At conclusion of the study it was found that the prophylactic usage of inj. palonosetron 75 mcg i.v. is more effective than inj. ondansetron 8mg i.v. in the prevention of PONV in patients undergoing laparoscopic surgery (p value < 0.05).

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References

Miller R. Miller's anesthesia. Philadelphia PA: Elsevier Saunders; 2015.

Elsaid R, Namrouti A, Samara A, Sadaqa W, Zyoud S. Assessment of pain and postoperative nausea and vomiting and their association in the early postoperative period: an observational study from Palestine. BMC Surgery. 2021;21(1).

Nagarekha D, Shaikh S, Hegade G, Marutheesh M. Postoperative nausea and vomiting: A simple yet complex problem. Anesthesia: Essays and Researches. 2016;10(3):388.

Nanavati A, Prabhakar S. Fast-track surgery: Toward comprehensive peri-operative care. Anesthesia: Essays and Researches. 2014;8(2):127.

Islam S, Jain PN. Post-operative nausea and vomiting (PONV): A review article. Indian Journal of Anaesthesia. 2004;48(4):253-8.

Bunce KT, Tyers MB. The role of 5-HT in postoperative nausea and vomiting. British Journal of Anaesthesia. 1992;69(7 Suppl 1):60S-2S.

Gan TJ, Meyer T, Apfel CC, Chung F, Davis PJ, Eubanks S, Kovac A, Philip BK, Sessler DI, Temo J, Tramèr MR. Consensus guidelines for managing postoperative nausea and vomiting. Anesthesia & Analgesia. 2003;97(1):62-71.

Tramer M, Reynolds D, Moore R, McQuay H. Efficacy, Dose-Response, and Safety of Ondansetron in Prevention of Postoperative Nausea and Vomiting. Anesthesiology. 1997;87(6):1277-1289.

Bednarz S, Filipovic M, Schoch O, Mauermann E. Gastric rupture after bag-mask-ventilation. Respiratory medicine case reports. 2015;16:1-2.

Paventi S, Santevecchi A, Ranieri R. Efficacy of a single-dose ondansetron for preventing post-operative nausea and vomiting after laparoscopic cholecystectomy with sevoflurane and remifentanil infusion anaesthesia. European review for medical and pharmacological sciences. 2001;5:59-64.

Kovac AL. Prevention and treatment of postoperative nausea and vomiting. Drugs. 2000;59(2):213-43.

Park SK, Cho EJ. A Randomised, double-blind trial of palonosetron compared with ondansetron in preventing postoperative nausea and vomiting after gynaecological laparoscopic surgery. Journal of International Medical Research. 2011;39(2):399-407.

Moon YE. Postoperative nausea and vomiting. Korean journal of anesthesiology. 2014;67(3):164.

Published

08-04-2022

How to Cite

Chauhan, D., Sharma, T., & Naik, G. C. (2022). Antiemetic effect of intravenous palonosetron and ondansetron for the prevention of postoperative nausea and vomiting following laparoscopic surgeries under general anaesthesia, a randomised observational study. International Journal of Health Sciences, 6(S2), 2778–2784. https://doi.org/10.53730/ijhs.v6nS2.5694

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Issue

Vol. 6 No. S2 (2022)

Section

Peer Review Articles

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