Anti mullerian hormone and antral follicle count for prediction of ovarian reserve in female infertile patients: A cross sectional study

Aakriti Aryal; Vishnu G. Vandana; C. V. Meghana; Dasari Himaja; D. Sandeep; S. Sarumathy; Melvin George; R. Roopini

doi:10.53730/ijhs.v6nS3.5723

Authors

Aakriti Aryal Department of Pharmacy Practice, SRM College of Pharmacy, Faculty of Medicine & Health Sciences, SRM Institute of Science and Technology, Kattankulathur, 603203, Chengalpattu (DT), TN, India
Vishnu Vandana G. Department of Pharmacy Practice, SRM College of Pharmacy, Faculty of Medicine & Health Sciences, SRM Institute of Science and Technology, Kattankulathur, 603203, Chengalpattu (DT), TN, India
Meghana C. V. Department of Pharmacy Practice, SRM College of Pharmacy, Faculty of Medicine & Health Sciences, SRM Institute of Science and Technology, Kattankulathur, 603203, Chengalpattu (DT), TN, India
Dasari Himaja Department of Pharmacy Practice, SRM College of Pharmacy, Faculty of Medicine & Health Sciences, SRM Institute of Science and Technology, Kattankulathur, 603203, Chengalpattu (DT), TN, India
Sandeep D. Department of Pharmacy Practice, SRM College of Pharmacy, Faculty of Medicine & Health Sciences, SRM Institute of Science and Technology, Kattankulathur, 603203, Chengalpattu (DT), TN, India
Sarumathy S. Department of Pharmacy Practice, SRM College of Pharmacy, Faculty of Medicine & Health Sciences, SRM Institute of Science and Technology, Kattankulathur, 603203, Chengalpattu (DT), TN, India
Melvin George Department of Cardiology, SRM Medical College Hospital and Research Centre, Faculty of Medicine & Health Sciences, SRM Institute of Science and Technology, Kattankulathur, 603203, Chengalpattu (DT), TN, India
Roopini R. Department of Pharmacy Practice, SRM College of Pharmacy, Faculty of Medicine & Health Sciences, SRM Institute of Science and Technology, Kattankulathur, 603203, Chengalpattu (DT), TN, India

Keywords:

infertility, ovarian reserve, anti mullerian-hormone, antral follicle count

Abstract

Ovarian reserve (OR)determines the quantity and quality of follicles present in the ovary. It is independent of menstrual cycle in women of reproductive age. The chances of conceiving in infertile women can be predicted by understanding and determining the OR. The aim of the study was to assess and determine whether Anti-Mullerian Hormone (AMH) with Antral Follicle Count (AFC) or AMH alone is a better predictor of ovarian reserve in female infertile patients. Methods: In this prospective, cross-sectional study, a total of 60 patients were measured for AMH levels of which 30 patients was assessed along with AFC. The demographic details were collected and 5ml of venous blood samples were taken on day 2 of menstrual cycle. Serum was separated and stored at -20^oC. Serum AMH levels were analysed using enzyme-linked immune sorbent assay (ELISA) whereas Antral Follicle Count with ultrasonography. Finally, 54 patients completed the analysis with the mean age of 26.32±3.95 years and body mass index of 24.09±4.62. The average AMH levels and AFC were found to be 2.49±4.05 ng/ml and 14.92±8.69 follicles respectively. AMH showed negative correlation with both FSH and LH and no correlation with estradiol.

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