Hypoalbuminemia as an early predictor of severe COVID-19 infection
A retrospective observational study
Keywords:
COVID-19, SARS-CoV 2, serum albumin, hypoalbuminemiaAbstract
Objectives: Several unique characteristics have been found in severe COVID19, such as lymphopenia, old age, high CRP level, elevated D dimer levels and underlying comorbid diseases. Serum albumin, being a negative acute phase reactant has been found to be associated with inflammatory response and poor outcomes in infectious diseases. The aim of the study was to analyse whether the serum albumin levels on admission might reflect the severity of systemic inflammation in COVID 19 infection and thus serve as an early predictive factor for COVID 19 outcomes. Materials and Method: This retrospective observational study included 185 COVID-19 positive patients. Laboratory data was recorded from blood samples collected at admission and analyzed by standard methods in the laboratory. Hypoalbuminemia was defined as serum albumin levels <3.5g/dl. p < 0.05 was considered statistically significant. Results: In the 185 COVID 19 patients studied, average age was 51.29 (±15.68) years. The study population had a male predominance (68.11%). 85 (45.95%) individuals were found to have hypoalbuminemia on admission. 18 (9.73%) deaths were reported amongst the study population and a significant association was found between low serum albumin levels on admission and mortality.(p < 0.001).
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References
WHO Coronavirus (COVID-19) Dashboard [Internet]. [cited 2021 Nov 25]. Available from: https://covid19.who.int
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020 Mar 28;395(10229):1054–62.
Zhang Y, Zheng L, Liu L, Zhao M, Xiao J, Zhao Q. Liver impairment in COVID-19 patients: A retrospective analysis of 115 cases from a single centre in Wuhan city, China. Liver Int. 2020 Sep;40(9):2095–103.
Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al. Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China. Clin Infect Dis. 2020 Jul 28;71(15):762–8.
He X, Yao F, Chen J, Wang Y, Fang X, Lin X, et al. The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients. Sci Rep. 2021 Jan 19;11(1):1–7.
Ejaz H, Alsrhani A, Zafar A, Javed H, Junaid K, Abdalla AE, et al. COVID-19 and comorbidities: Deleterious impact on infected patients. J Infect Public Health. 2020 Dec;13(12):1833–9.
Huang J, Cheng A, Kumar R, Fang Y, Chen G, Zhu Y, et al. Hypoalbuminemia predicts the outcome of COVID‐19 independent of age and co‐morbidity. J Med Virol [Internet]. [cited 2021 Oct 27]; Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273060/
Aziz M, Fatima R, Lee-Smith W, Assaly R. The association of low serum albumin level with severe COVID-19: a systematic review and meta-analysis. Crit Care. 2020 May 26;24(1):255.
Xu Y, Yang H, Wang J, Li X, Xue C, Niu C, et al. Serum Albumin Levels are a Predictor of COVID-19 Patient Prognosis: Evidence from a Single Cohort in Chongqing, China. IJGM. 2021 Jun 24;14:2785–97.
Viana-Llamas MC, Arroyo-Espliguero R, Silva-Obregón JA, Uribe-Heredia G, Núñez-Gil I, García-Magallón B, et al. Hypoalbuminemia on admission in COVID-19 infection: An early predictor of mortality and adverse events. A retrospective observational study. Med Clin . 2021 May 7;156(9):428–36.
Soeters PB, Wolfe RR, Shenkin A. Hypoalbuminemia: Pathogenesis and Clinical Significance. JPEN J Parenter Enteral Nutr. 2019 Feb;43(2):181–93.
Ramadori G. Hypoalbuminemia: an underestimated, vital characteristic of hospitalized COVID-19 positive patients? Hepatoma Research. 2020 Jun 3;6:28.
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