Role of platelet count in diagnosis of oral potentially malignant disorders and oral squamous cell carcinoma
Keywords:
Leukoplakia, Oral Submucous fibrosis, Oral squamous cell carcinoma, platelet countAbstract
Introduction: Platelets play an important role in the metabolic functions of malignant tissues. Platelet count is the major marker for malignancy and their increase in number can depict stages, severity and metastasis of cancer. Increase in number of platelet count can be used in early diagnosis of cancer. However, use of some chemotherapeutic agents is associated with low platelet count. Therefore, the platelet to cancer cell ratio varies through the course of the disease and is highly affected by treatment. Aim: To assess correlation between platelet count and progression of malignancy. Materials and method: Platelet counts were retrieved from patients diagnosed oral potentially malignat disorders and oral squamous cell carcinoma based on clinical data. The collected data is analyzed to correlate the platelet count in oral potentially malignat disorders and oral squamous cell carcinoma compared to healthy control patients. Result: Nonsignificant differnce was noted in platelet count in oral potentially malignat disorders and oral squamous cell carcinoma compared to healthy control patients. Conclusion: Thrombocystosis is a poor predicator for malignancy, platelet count alone cannot determine the severity of malignancy, correlation with histopathologic data can better establish the grading of malignancy.
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