Viral load and B-catenin level correlation study in patients with chronic hepatitis B virus

Abdullah A. Mohammed; Sura A. Abdulsattar; Sabeha Al-bayati

doi:10.53730/ijhs.v6nS2.5815

Authors

Abdullah A. Mohammed
Abdullah.medical@uofallujah.edu.iq
Department of Chemistry and Biochemistry, College of Medicine, Mustansiriyah University, Iraq
Sura A. Abdulsattar Department of Chemistry and Biochemistry, College of Medicine, Mustansiriyah University, Iraq
Sabeha Al-bayati Department of internal medicine, College of Medicine, Mustansiriyah University, Iraq

Keywords:

viral hepatitis, autoimmune diseases, hepatitis B X protein (HBx), real time PCR, viral load

Abstract

Hepatitis a general term which refers to inflammation of the liver. It may result from various causes, both infectious ( viral, bacterial, fungal, and parasitic) and noninfectious (alcohol, drugs, autoimmune diseases, and metabolic diseases). The hepatitis B X protein (HBx) plays a role in the epigenetic regulation of HBV replication. Real-time PCR has catalysed wider acceptance of PCR because it is more rapid, sensitive and reproducible, while the risk of carryover contamination is minimised. The present study is a case-control study design comprise a total of 58 patient with hepatitis B of which 29 patients were with chronic infection and additional 29 patient with chronic hepatitis, and 30 apparently healthy control subjects. In the current study, fifty - eight diagnosed hepatitis B virus patients were enrolled. The correlations of study biomarkers with viral load in the (chronic hepatitis group) of HBV patients. B-catenin showed a significant positive correlation with viral load in chronic hepatitis group (r = 0.387, p = 0.038).

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