Effect of flavonoids on bond strength of dentin adhesives
A systematic review
Keywords:
flavonoids, bond strength, dentin adhesivesAbstract
The effectiveness of adhesive restorations depends on a durable long-term dentin bond. Due to collagen fibril denaturation, the consistency and durability of bonding to caries-affected dentin can be questioned as compared to sound dentin. Exogenous cross-linking agents have been suggested as a viable method of inhibiting MMP activity and retaining collagen within the dentin-bonded interface. Due to their strong antioxidant capacity, flavonoids are natural cross linkers that play an important role in protecting unprotected collagen fibrils inside the hybrid layer. This study aimed to evaluate the effectiveness of flavonoids incorporated dentin adhesives in improving the bond strength of composite resin. A search was performed in the electronic databases (PUBMED CENTRAL, Medline, Scopus, Lilacs, Science Direct, Google scholar and Hand Search) using search terms alone and in combination by means of PUBMED search builder upto March 2021. Also cross check of reference was done on all potentially eligible articles. Initially 47 articles were identified.2 articles were removed because of duplicates. After title and abstract screening 27 articles were removed.After reading full texts,4 articles were removed and finally 14 articles were included in this review for detailed analysis.
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Vallittu PK. Bonding of hybrid composite resin to the surface of gold-alloy used in porcelain-fused-to-metal restorations [Internet]. Vol. 24, Journal of Oral Rehabilitation. 1997. p. 560–7. Available from: http://dx.doi.org/10.1046/j.1365-2842.1997.00546.x
Miletic V. Dental Composite Materials for Direct Restorations. Springer; 2017. 319 p.
Bächinger HP. Collagen: Primer in Structure, Processing and Assembly. Springer Science & Business Media; 2005. 252 p.
Zeidan LC, Reis AF, Cassoni A, Rodrigues JA. Effect of six month storage on microtensile bond strength of new elective etching adhesive system on dentin in self-etching or etch-and-rinse approach [Internet]. Vol. 8, The Saudi Journal for Dental Research. 2017. p. 5–10. Available from: http://dx.doi.org/10.1016/j.sjdr.2016.06.006
Almahdy A, Koller G, Festy F, Bartsch JW, Watson TF, Banerjee A. An MMP-inhibitor modified adhesive primer enhances bond durability to carious dentin [Internet]. Vol. 31, Dental Materials. 2015. p. 594–602. Available from: http://dx.doi.org/10.1016/j.dental.2015.03.003
Almahdy A, Koller G, Sauro S, Bartsch JW, Sherriff M, Watson TF, et al. Effects of MMP Inhibitors Incorporated within Dental Adhesives [Internet]. Vol. 91, Journal of Dental Research. 2012. p. 605–11. Available from: http://dx.doi.org/10.1177/0022034512446339
Maravic T, Mancuso E, Comba A, Checchi V, Generali L, Mazzitelli C, et al. Dentin Cross-linking Effect of Carbodiimide After 5 Years. J Dent Res. 2021 Sep;100(10):1090–8.
Zeitoune AA, Bersanetti PA, Schor P, Erbes LA, Cesar CL, Adur J. Comparison of morphological changes of corneal collagen fibers treated with collagen crosslinking agents using second harmonic generation images. Int J Biol Macromol. 2020 Dec 15;165(Pt A):346–53.
Mahyudin F, Hermawan H. Biomaterials and Medical Devices: A Perspective from an Emerging Country. Springer; 2016. 242 p.
McAnulty RJ, Laurent GJ. Collagen Synthesis and Degradation In Vivo. Evidence for Rapid Rates of Collagen Turnover with Extensive Degradation of Newly Synthesized Collagen in Tissues of the Adult Rat [Internet]. Vol. 7, Collagen and Related Research. 1987. p. 93–104. Available from: http://dx.doi.org/10.1016/s0174-173x(87)80001-8
Tanzer ML. Collagen Biosynthesis and Degradation [Internet]. Disorders of Mineral Metabolism. 1982. p. 237–70. Available from: http://dx.doi.org/10.1016/b978-0-12-135302-5.50011-0
Porto ICCM, Porto ICC, França R. Effect of natural polyphenols on resin–dentin bond strength [Internet]. Vol. 31, Dental Materials. 2015. p. e34–5. Available from: http://dx.doi.org/10.1016/j.dental.2015.08.078
Epasinghe DJ, Yiu CKY, Burrow MF. Effect of proanthocyanidin incorporation into dental adhesive on durability of resin–dentin bond [Internet]. Vol. 63, International Journal of Adhesion and Adhesives. 2015. p. 145–51. Available from: http://dx.doi.org/10.1016/j.ijadhadh.2015.09.006
Filho VC. Natural Products as Source of Molecules with Therapeutic Potential: Research & Development, Challenges and Perspectives. Springer; 2018. 531 p.
Fang H, Li Q-L, Han M, Mei ML, Chu CH. Anti-proteolytic property and bonding durability of mussel adhesive protein-modified dentin adhesive interface [Internet]. Vol. 33, Dental Materials. 2017. p. 1075–83. Available from: http://dx.doi.org/10.1016/j.dental.2017.07.008
Li Y. GELATIN MICROGEL INCORPORATED POLY (ETHYLENE GLYCOL) BIOADHESIVE WITH ENHANCED ADHESIVE PROPERTY AND BIOACTIVITY [Internet]. Available from: http://dx.doi.org/10.37099/mtu.dc.etds/999
Venezky DL. Adhesive Restorative Dental Materials: A Literature Survey of Inorganic Polymers. 1965. 78 p.
Manly R. Adhesion in Biological Systems. Elsevier; 2012. 318 p.
Mendes BN, Bridi EC, França FMG, Turssi CP, do Amaral FLB, Basting RT, et al. Polyphenol-enriched extract of Arrabidaea chica used as a dentin pretreatment or incorporated into a total-etching adhesive system: Effects on bonding stability and physical characterization. Mater Sci Eng C Mater Biol Appl. 2020 Nov;116:111235.
Yu H-H, Zhang L, Yu F, Li F, Liu Z-Y, Chen J-H. Epigallocatechin-3-gallate and Epigallocatechin-3-O-(3-O-methyl)-gallate Enhance the Bonding Stability of an Etch-and-Rinse Adhesive to Dentin. Materials [Internet]. 2017 Feb 15;10(2). Available from: http://dx.doi.org/10.3390/ma10020183
Vidal CMP, Aguiar TR, Phansalkar R, McAlpine JB, Napolitano JG, Chen S-N, et al. Galloyl moieties enhance the dentin biomodification potential of plant-derived catechins. Acta Biomater. 2014 Jul;10(7):3288–94.
de Macedo FAA, Souza NO, Lemos MVS, De-Paula DM, Santiago SL, Feitosa VP. Dentin bonding and physicochemical properties of adhesives incorporated with epigallocatechin-3-gallate. Odontology. 2019 Jan;107(1):23–8.
Du X, Huang X, Huang C, Wang Y, Zhang Y. Epigallocatechin-3-gallate (EGCG) enhances the therapeutic activity of a dental adhesive [Internet]. Vol. 40, Journal of Dentistry. 2012. p. 485–92. Available from: http://dx.doi.org/10.1016/j.jdent.2012.02.013
Yun J-H, Pang E-K, Kim C-S, Yoo Y-J, Cho K-S, Chai J-K, et al. Inhibitory effects of green tea polyphenol (-)-epigallocatechin gallate on the expression of matrix metalloproteinase-9 and on the formation of osteoclasts. J Periodontal Res. 2004 Oct;39(5):300–7.
Ho Y-C, Yang S-F, Peng C-Y, Chou M-Y, Chang Y-C. Epigallocatechin-3-gallate inhibits the invasion of human oral cancer cells and decreases the productions of matrix metalloproteinases and urokinase-plasminogen activator. J Oral Pathol Med. 2007 Nov;36(10):588–93.
Yang H, Li K, Yan H, Liu S, Wang Y, Huang C. High-performance therapeutic quercetin-doped adhesive for adhesive-dentin interfaces. Sci Rep. 2017 Aug 15;7(1):8189.
Porto ICC de M, Rocha AB de B, Ferreira IIS, de Barros BM, Ávila EC, da Silva MC, et al. Polyphenols and Brazilian red propolis incorporated into a total-etching adhesive system help in maintaining bonding durability. Heliyon. 2021 Feb;7(2):e06237.
Islam S, Hiraishi N, Nassar M, Yiu C, Otsuki M, Tagami J. Effect of natural cross-linkers incorporation in a self-etching primer on dentine bond strength [Internet]. Vol. 40, Journal of Dentistry. 2012. p. 1052–9. Available from: http://dx.doi.org/10.1016/j.jdent.2012.08.015
Gotti VB, Feitosa VP, Sauro S, Correr-Sobrinho L, Leal FB, Stansbury JW, et al. Effect of antioxidants on the dentin interface bond stability of adhesives exposed to hydrolytic degradation. J Adhes Dent. 2015 Feb;17(1):35–44.
Khalid S, Rafique MA, Khan AS. Application of natural crosslinkers on tooth surface: an in-vitro comparative evaluation of resin-dentin bond strength. J Pak Med Assoc. 2020 Aug;70(8):1363–70.
Nowshehri JA, Bhat ZA, Shah MY. Blessings in disguise: Bio-functional benefits of grape seed extracts [Internet]. Vol. 77, Food Research International. 2015. p. 333–48. Available from: http://dx.doi.org/10.1016/j.foodres.2015.08.026
Seseogullari-Dirihan R, Apollonio F, Mazzoni A, Tjaderhane L, Pashley D, Breschi L, et al. Use of crosslinkers to inactivate dentin MMPs. Dent Mater. 2016 Mar;32(3):423–32.
Ku CS, Mun SP. Characterization of proanthocyanidin in hot water extract isolated from Pinus radiata bark [Internet]. Vol. 41, Wood Science and Technology. 2007. p. 235–47. Available from: http://dx.doi.org/10.1007/s00226-006-0103-8
Epasinghe DJ, Yiu CKY, Burrow MF, Tay FR, King NM. Effect of proanthocyanidin incorporation into dental adhesive resin on resin–dentine bond strength [Internet]. Vol. 40, Journal of Dentistry. 2012. p. 173–80. Available from: http://dx.doi.org/10.1016/j.jdent.2011.11.013
Beck F, Ilie N. Antioxidants and Collagen-Crosslinking: Benefit on Bond Strength and Clinical Applicability. Materials [Internet]. 2020 Dec 1;13(23). Available from: http://dx.doi.org/10.3390/ma13235483
Islam MS, Hiraishi N, Nassar M, Yiu C, Otsuki M, Tagami J. Effect of hesperidin incorporation into a self-etching primer on durability of dentin bond. Dent Mater. 2014 Nov;30(11):1205–12.
Ghorab S, Ibraheim A. Effect of hesperidin on antibacterial activity and adhesive properti es of an etch-and-rinse adhesive system [Internet]. Vol. 64, Egyptian Dental Journal. 2018. p. 3801–12. Available from: http://dx.doi.org/10.21608/edj.2018.79355
Virdi M. Emerging Trends in Oral Health Sciences and Dentistry. BoD – Books on Demand; 2015. 854 p.
Xu J, Li M, Wang W, Wu Z, Wang C, Jin X, et al. A novel prime-&-rinse mode using MDP and MMPs inhibitors improves the dentin bond durability of self-etch adhesive. J Mech Behav Biomed Mater. 2020 Apr;104:103698.
Taschner M, Nato F, Mazzoni A, Frankenberger R, Falconi M, Petschelt A, et al. Influence of preliminary etching on the stability of bonds created by one-step self-etch bonding systems [Internet]. Vol. 120, European Journal of Oral Sciences. 2012. p. 239–48. Available from: http://dx.doi.org/10.1111/j.1600-0722.2012.00960.x
de Souza LC, Rodrigues NS, Cunha DA, Feitosa VP, Santiago SL, Reis A, et al. Two-year clinical evaluation of proanthocyanidins added to a two-step etch-and-rinse adhesive. J Dent. 2019 Feb;81:7–16.
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