Neurological complications in COVID 19
An analytical study
Keywords:
neurological complications, COVID 19, haemorrhage, ischemic stroke, parkinsonism, dementia, anxiety disorders, psychotic illnessAbstract
Long term effects of COVID-19 are not known and more studiesare needed to understand effects of COVID-19 on the brain, which have already been observed. An investigation on the incidence and relative risk of neurological and mental disorders after a COVID-19 diagnosis was part of this research. We used data from the electronic well-being records network in this review partner investigation. On or after June1st, 2021, members of all partners experienced a list occasion and were still living on December 31st, 2021, disregarding maturation, at the end of the year. All patients who had a confirmed finding of COVID-19 were allocated in this study. Patients with flu and those with any respiratory illness, including flu, were included in the second group of controls. The neurological symptoms were accessed and quantified according to the two groups and then statistically analysed for the significance. It was calculated that 82% of the 200 people identified with COVID-19 got a neurological or psychiatric diagnosis during the next six months.
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References
Rogers JP Chesney E Oliver D et al.Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic.Lancet Psychiatry. 2020; 7: 611-627
Ellul MA Benjamin L Singh B et al.Neurological associations of COVID-19.Lancet Neurol. 2020; 19: 767-783
Varatharaj A Thomas N Ellul MA et al.Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study.Lancet Psychiatry. 2020; 7: 875-882
Paterson RW Brown RL Benjamin L et al.The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings.Brain. 2020; 143: 3104-3120
Kremer S Lersy F Anheim M et al.Neurologic and neuroimaging findings in patients with COVID-19: a retrospective multicenter study.Neurology. 2020; 95: e1868-e1882
Pezzini A PadovaniALifting the mask on neurological manifestations of COVID-19.
Nat Rev Neurol. 2020; 16: 636-644
Raman B Cassar MP Tunnicliffe EM et al.Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge.EClinicalMedicine. 2021; 31100683
Iadecola C Anrather J Kamel HEffects of COVID-19 on the nervous system.Cell. 2020; 183: 16-27
Kreye J Reincke SM Prüss HDo cross-reactive antibodies cause neuropathology in COVID-19?.Nat Rev Immunol. 2020; 20: 645-646
Meinhardt J Radke J Dittmayer C et al.Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19.Nat Neurosci. 2021; 24: 168-175
Rhea EM Logsdon AF Hansen KM et al.The S1 protein of SARS-CoV-2 crosses the blood-brain barrier in mice.Nat Neurosci. 2021; 24: 368-378
Holmes EA O'Connor RC Perry VH et al.Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science.Lancet Psychiatry. 2020; 7: 547-560
Vindegaard N Benros MECOVID-19 pandemic and mental health consequences: systematic review of the current evidence.Brain Behav Immun. 2020; 89: 531-542
Taquet M Luciano S Geddes JR Harrison PJBidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA.Lancet Psychiatry. 2021; 8: 130-140
de Lusignan S Dorward J Correa A et al.Risk factors for SARS-CoV-2 among patients in the Oxford Royal College of General Practitioners Research and Surveillance Centre primary care network: a cross-sectional study.Lancet Infect Dis. 2020; 20: 1034-1042
Williamson EJ Walker AJ Bhaskaran K et al.Factors associated with COVID-19-related death using OpenSAFELY.Nature. 2020; 584: 430-436
Slooter AJC Otte WM Devlin JW et al.Updated nomenclature of delirium and acute encephalopathy: statement of ten Societies.Intensive Care Med. 2020; 46: 1020-1022
Oldham MA Slooter AJC Cunningham C et al.Characterising neuropsychiatric disorders in patients with COVID-19.Lancet Psychiatry. 2020; 7: 932-933
Austin PCAn introduction to propensity score methods for reducing the effects of confounding in observational studies.Multivariate Behav Res. 2011; 46: 399-424
Haukoos JS Lewis RJThe propensity score.JAMA. 2015; 314: 1637-1638
Royston P Parmar MKBFlexible parametric proportional-hazards and proportional-odds models for censored survival data, with application to prognostic modelling and estimation of treatment effects.Stat Med. 2002; 21: 2175-2197
Panigada M Bottino N Tagliabue P et al.Hypercoagulability of COVID-19 patients in intensive care unit: a report of thromboelastography findings and other parameters of hemostasis.J ThrombHaemost. 2020; 18: 1738-1742
Siow I Lee KS Zhang JJY Saffari SE Ng A Young BStroke as a neurological complication of COVID-19: a systematic review and meta-analysis of incidence, outcomes and predictors.J Stroke Cerebrovasc Dis. 2021; 30105549
Hernandez-Fernandez F Valencia HS Barbella-Aponte R et al.Cerebrovascular disease in patients with COVID-19: neuroimaging, histological and clinical description.Brain. 2020; 143: 3089-3103
Xie Y Bowe B Maddukuri G Al-Aly ZComparative evaluation of clinical manifestations and risk of death in patients admitted to hospital with COVID-19 and seasonal influenza: cohort study.BMJ. 2020; 371m4677
Keddie S Pakpoor J Mousele C et al.Epidemiological and cohort study finds no association between COVID-19 and Guillain-Barré syndrome.Brain. 2020; (published online Dec 14.)https://doi.org/10.1093/brain/awaa433
Hoffman LA Vilensky JAEncephalitis lethargica: 100 years after the epidemic.Brain. 2017; 140: 2246-2251
Watson CJ Thomas RH Solomon T Michael BD Nicholson TR Pollak TACOVID-19 and psychosis risk: real or delusional concern?.Neurosci Lett. 2021; 741135491
Casey JA Schwartz BS Stewart WF Adler NEUsing electronic health records for population health research: a review of methods and applications.Annu Rev Public Health. 2016; 37: 61-81
Docherty AB Harrison EM Green CA et al.Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.BMJ. 2020; 369m1985DOI: https://doi.org/10.1016/S2215-0366(21)00084-5
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