Role of optical coherence tomography angiography in early detection of retinal microvascular changes in adolescents with type 1 diabetes

https://doi.org/10.53730/ijhs.v6nS4.6049

Authors

  • Radwa A. Shamma Lecturer of Pediatrics, Department of Pediatrics, The Diabetes, Endocrine and Metabolism Pediatric Unit (DEMPU), an ESPE & ISPAD member, Faculty of Medicine, P.O. box: 11461, Cairo University, Cairo, Egypt
  • Yomna A. Hosni Assistant Lecturer of Pediatrics, Department of Pediatrics, The Diabetes, Endocrine and Metabolism Pediatric Unit (DEMPU), Faculty of Medicine, P.O. box: 11461, Cairo University, Cairo, Egypt
  • Mona M. Hassan Professor of Pediatrics, Department of Pediatrics, Head of the Diabetes Endocrine and Metabolism Pediatric Unit (DEMPU), an ESPE member, Faculty of Medicine, P.O. box: 11461, Cairo University, Cairo, Egypt
  • Nihal A. Hassan Professor of Ophthalmology, Department of Ophthalmology, Faculty of Medicine, P.O. box: 11461, Cairo University, Cairo, Egypt
  • Dina Khedr Lecturer of Pediatrics, Department of Pediatrics, The Diabetes, Endocrine and Metabolism Pediatric Unit (DEMPU), an ASPED member, Faculty of Medicine, P.O. box: 11461, Cairo University, Cairo, Egypt

Keywords:

diabetic retinopathy, type 1 diabetes, OCT, OCTA

Abstract

Purpose: Early detection of diabetic retinopathy can prevent progressive visual loss. Evaluate the role of Optical Coherence Tomography Angiography (OCTA) in early detection of diabetic retinopathy (DR) in type 1 diabetes (T1D) adolescents with normal fundus photography. Methods: Cross-sectional study included 150 eyes of 75 T1D adolescents from the Diabetes Endocrine and Metabolism Pediatric Unit, Children hospital, Cairo University. Their ages ranged from 10-18 years and diabetes duration 2 years or more. Fundus photography, OCT and OCTA were done in the diagnostic and laser unit, Ophthalmology department. Results: Twenty-eight patients (37.3%) had abnormalities in the OCTA despite normal fundus examination, photography and OCT. Diabetes duration, DKA at presentation and frequency, elevated blood pressure, limited joint mobility, elevated HbA1c and dyslipidemia had a negative correlation with OCTA measurements (foveal, parafoveal and perifoveal densities). Patients with abnormal OCTA had significantly higher mean age, higher DKA frequency, and lower height SDS (p=0.034, 0.011 and 0.001 respectively). Univariate and multivariate analysis revealed age and DKA at diabetes presentation are significant predictors for abnormal OCTA. Conclusion: OCTA can be used in early detection of diabetic retinopathy in T1D adolescents especially with risk factors (Elevated HbA1c, frequent DKA, decreased height SDS and limited joint mobility).

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Published

15-04-2022

How to Cite

Shamma, R. A., Hosni, Y. A., Hassan, M. M., Hassan, N. A., & Khedr, D. (2022). Role of optical coherence tomography angiography in early detection of retinal microvascular changes in adolescents with type 1 diabetes. International Journal of Health Sciences, 6(S4), 1337–1353. https://doi.org/10.53730/ijhs.v6nS4.6049

Issue

Vol. 6 No. S4 (2022)

Section

Peer Review Articles
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