To compare the levels of salivary Interleukin 6 between oral potentially malignant disorders and oral squamous cell carcinoma
Keywords:
OSCC, OSMF, IL-6Abstract
To compare the levels of salivary Interleukin 6 between oral potentially malignant disorders and oral squamous cell carcinoma. After ethical clearance and informed consent, the saliva samples were collected from 20 patients of OPMD’S, 20 patients of OSCC and 10 controls. Salivary IL-6 levels were detected by enzyme linked Immunosorbent essay and appropriate statistical analysis was done. Significant differences in IL-6 concentration between OSCC, OPMD’S and controls were noted. Salivary IL-6 levels were higher in OSCC. The results of present study concluded that the level of salivary IL-6 in OSCC is significantly higher than oral potentially malignant disorders like OSMF and oral epithelial dysplasia and controls. This biomarker can be utilized as a major asset for early detection of cancer and can open a new horizon for treatment plans of targeted therapy.
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Balsaraf S, Bhambal A, Chole R. Study of oral potentially malignant disorders related to various risk factors amongst the patients attending hospitals in Bhopal, India. Med Pharm Rep. 2019 Jan;92(1):66-71. doi: 10.15386/cjmed-906. Epub 2019 Jan 15. PMID: 30957089; PMCID: PMC6448500. DOI: https://doi.org/10.15386/cjmed-906
Kaur J, Jacobs R. Proinflammatory cytokine levels in oral lichen planus, oral leukoplakia, and oral submucous fibrosis. J Korean Assoc Oral Maxillofac Surg. 2015 Aug;41(4):171-5. doi: 10.5125/jkaoms.2015.41.4.171. Epub 2015 Aug 21. PMID: 26339574; PMCID: PMC4558184. DOI: https://doi.org/10.5125/jkaoms.2015.41.4.171
Sahibzada HA, Khurshid Z, Khan RS, Naseem M, Siddique KM, Mali M, Zafar MS. Salivary IL-8, IL-6 and TNF-α as Potential Diagnostic Biomarkers for Oral Cancer. Diagnostics (Basel). 2017 Apr 9;7(2):21. doi: 10.3390/diagnostics7020021. PMID: 28397778; PMCID: PMC5489941. DOI: https://doi.org/10.3390/diagnostics7020021
Gan SD, Patel KR. Enzyme immunoassay and enzyme-linked immunosorbent assay. J Invest Dermatol. 2013 Sep;133(9):e12. doi: 10.1038/jid.2013.287. PMID: 23949770. DOI: https://doi.org/10.1038/jid.2013.287
Kapila SN, Natarajan S, Boaz K. A Comparison of Clinicopathological Differences in Oral Squamous Cell Carcinoma in Patients Below and Above 40 Years of Age. J Clin Diagn Res. 2017 Sep;11(9):ZC46-ZC50. doi: 10.7860/JCDR/2017/27828.10600. Epub 2017 Sep 1. PMID: 29207832; PMCID: PMC5713854. DOI: https://doi.org/10.7860/JCDR/2017/27828.10600
Abdulla R, Adyanthaya S, Kini P, Mohanty V, D'Souza N, Subbannayya Y. Clinicopathological analysis of oral squamous cell carcinoma among the younger age group in coastal Karnataka, India: A retrospective study. J Oral Maxillofac Pathol. 2018 May-Aug;22(2):180-187. doi: 10.4103/jomfp.JOMFP_16_18. PMID: 30158769; PMCID: PMC6097353. DOI: https://doi.org/10.4103/jomfp.JOMFP_16_18
Jethwa AR, Khariwala SS. Tobacco-related carcinogenesis in head and neck cancer. Cancer Metastasis Rev. 2017 Sep;36(3):411-423. doi: 10.1007/s10555-017-9689-6. PMID: 28801840; PMCID: PMC5709040. DOI: https://doi.org/10.1007/s10555-017-9689-6
Dineshkumar T, Ashwini BK, Rameshkumar A, Rajashree P, Ramya R, Rajkumar K. Salivary and Serum Interleukin-6 Levels in Oral Premalignant Disorders and Squamous Cell Carcinoma: Diagnostic Value and Clinicopathologic Correlations. Asian Pac J Cancer Prev. 2016 Nov 1;17(11):4899-4906. doi: 10.22034/APJCP.2016.17.11.4899. PMID: 28032493; PMCID: PMC5454693.
Shenoi R, Devrukhkar V; Chaudhuri, Sharma BK, Sapre SB, Chikhale A. Demographic and clinical profile of oral squamous cell carcinoma patients: a retrospective study. Indian J Cancer. 2012 Jan-Mar;49(1):21-6. doi: 10.4103/0019-509X.98910. PMID: 22842164. DOI: https://doi.org/10.4103/0019-509X.98910
Juretić M, Cerović R, Belušić-Gobić M, Brekalo Pršo I, Kqiku L, Špalj S, Pezelj-Ribarić S. Salivary levels of TNF-α and IL-6 in patients with oral premalignant and malignant lesions. Folia Biol (Praha). 2013;59(2):99-102. PMID: 23746176.
Babiuch K, Kuśnierz-Cabala B, Kęsek B, Okoń K, Darczuk D, Chomyszyn-Gajewska M. Evaluation of Proinflammatory, NF-kappaB Dependent Cytokines: IL-1α, IL-6, IL-8, and TNF-α in Tissue Specimens and Saliva of Patients with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders. J Clin Med. 2020 Mar 21;9(3):867. doi: 10.3390/jcm9030867. PMID: 32245251; PMCID: PMC7141524. DOI: https://doi.org/10.3390/jcm9030867
Brailo V, Vucicevic-Boras V, Lukac J, Biocina-Lukenda D, Zilic-Alajbeg I, Milenovic A, Balija M. Salivary and serum interleukin 1 beta, interleukin 6 and tumor necrosis factor alpha in patients with leukoplakia and oral cancer. Med Oral Patol Oral Cir Bucal. 2012 Jan 1;17(1):e10-5. doi: 10.4317/medoral.17323. PMID: 21743397; PMCID: PMC3448188. DOI: https://doi.org/10.4317/medoral.17323
Panneer Selvam N, Sadaksharam J. Salivary interleukin-6 in the detection of oral cancer and precancer. Asia Pac J Clin Oncol. 2015 Sep;11(3):236-41. doi: 10.1111/ajco.12330. Epub 2015 Jan 6. PMID: 25560781. DOI: https://doi.org/10.1111/ajco.12330
Park DG, Woo BH, Lee BJ, Yoon S, Cho Y, Kim YD, Park HR, Song JM. Serum Levels of Interleukin-6 and Titers of Antibodies Against Porphyromonas gingivalis Could Be Potential Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma. Int J Mol Sci. 2019 Jun 4;20(11):2749. doi: 10.3390/ijms20112749. PMID: 31167516; PMCID: PMC6600294 DOI: https://doi.org/10.3390/ijms20112749
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