Low dose Lung-CT as COVID-19 diagnostic tool while waiting for RT-PCR result
Keywords:
lung-CT, COVID-19, RT-PCR, multi-detector scannerAbstract
Reverse transcription‐polymerase chain reaction (RT‐PCR) assay as the standard of COVID19 diagnosis takes time, can only be done in limited laboratories, and sometimes produced false negative result; which made diagnosis and intervention become delayed. Meanwhile, chest CT takes little time and has high sensitivity in diagnosing COVID19. This study aimed to see the correlation of Chest CT with RT-PCR results in COVID19 patients. We performed a retrospective cohort study from symptomatic patients at Pantai Indah Kapuk Hospital in Jakarta, Indonesia. Multi-detector scanner CT was done, RT-PCR samples were taken and sent to the government appointed laboratory. Main outcome measures include correlation of CT patterns and CT severity index with RT-PCR. Data were processed with SPSS ver. 25.0 using gamma coefficient measure of agreement. Seventy-three patients were included and underwent chest CT and compared the result with RT-PCR. This study showed the very strong correlation (Gamma +0.897, p-value <0.05, CI 95%) between CT pattern with RT-PCR and no correlation (Gamma +0.241, p-value = 0.379, CI 95%) between CT severity index with RT-PCR. Chest CT has proven its superiority to be used as one of the most capable diagnostic devices for COVID19 patients.
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