Assessment of effects of antihypertensive agents on the quality of life in diabetic hypertensive patients
Keywords:
amlodipine, diabetes mellitus, hypertensionAbstract
Background: Hypertension affects a significant number of population and many of these affected individuals have no symptoms. The present study was conducted to assess effects of antihypertensive agents on the quality of life in diabetic hypertensive patients. Materials & Methods: 96 diabetic hypertensive patients of both genders were randomly divided into 4 groups based on antihypertensive medicines- group I comprises those taking amlodipine (2.5–10 mg/day), group II taking ramipril (2.5–10 mg/day), group III taking telmisartan (40–80 mg/day) and group IV taking combination of ramipril (1.25–5 mg/day) and telmisartan (20–40 mg/day) (RT). Parameters such as blood pressure (BP), pulse rate, blood sugar level, glycated hemoglobin (HbA1c) and QOLID-Punjabi version (PV) questionnaire at baseline and then at the 24th week of therapy. QoL of the patients was assessed by using the QOLID questionnaire Results: Group I had 12 males and 12 females, group II had 14 males and 10 females, group III had 15 males and 9 females and group IV had 10 males and 14 females.
Downloads
References
Agodoa LY, Appel L, Bakris GL, Beck G, Bourgoignie J, Briggs JP, et al. Effect of ramipril vs. amlodipine on renal outcomes in hypertensive nephrosclerosis: A randomized controlled trial. JAMA 2001;285:2719-28. DOI: https://doi.org/10.1001/jama.285.21.2719
Redon J, Mancia G, Sleight P, Schumacher H, Gao P, Pogue J, et al. Safety and efficacy of low blood pressures among patients with diabetes: Subgroup analyses from the ONTARGET (Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial). J Am Coll Cardiol 2012;59:74-83. DOI: https://doi.org/10.1016/j.jacc.2011.09.040
Gadge P, Gadge R, Paralkar N, Jain P, Tanna V. Effect of telmisartan on blood pressure in patients of type 2 diabetes with or without complications. Perspect Clin Res 2018;9:155-60.
Delles C, Raff U, Mimran A, Fauvel JP, Ruilope LM, Schmieder RE. Effects of telmisartan and ramipril on adiponectin and blood pressure in patients with type 2 diabetes. Am J Hypertens 2008;21:1330-6. DOI: https://doi.org/10.1038/ajh.2008.297
Morimoto S, Yano Y, Maki K, Sawada K. Renal and vascular protective effects of telmisartan in patients with essential hypertension. Hypertens Res 2006;29:567-72. DOI: https://doi.org/10.1291/hypres.29.567
Nakao N, Yoshimura A, Morita H, Takada M, Kayano T, Ideura T. Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): A randomised controlled trial. Lancet 2003;361:117-24. DOI: https://doi.org/10.1016/S0140-6736(03)12229-5
Kavi A, Walvekar P, Mallapur M. Assessment of health related quality of life of elderly diabetic patients attending urban primary health care facility-a cross sectional study. Int J Community Med Public Health 2017;3:2258-63. DOI: https://doi.org/10.18203/2394-6040.ijcmph20162580
Chaturvedi R, Desai C, Patel P, Shah A, Dikshit RK. An evaluation of the impact of antidiabetic medication on treatment satisfaction and quality of life in patients of diabetes mellitus. Perspect Clin Res 2018;9:15-22. DOI: https://doi.org/10.4103/picr.PICR_140_16
Prajapati VB, Blake R, Acharya LD, Seshadri S. Assessment of quality of life in type II diabetic patients using the modified diabetes quality of life (MDQoL)-17 questionnaire. Braz J Pharm Sci 2017;53; e17144-8. DOI: https://doi.org/10.1590/s2175-97902017000417144
Daivashiromani V, Kuna A, Devi SS, Kumari PA, Sowmya M. Effect of selected demographic characters on health- related quality of life (HRQOL) in Type 2 diabetic subjects of Hyderabad and Rangareddy districts of Telangana State. The J Res PJTSAU 2017;45:104-12.
Bhardwaj RK, Kazal H L, Kohli K, Raj R, Bansal N, Singh B, Arora H. Effects of antihypertensive agents on the quality of life in diabetic hypertensive patients: A prospective study. Perspect Clin Res
Akinyede AA, Nwaiwu O, Fasipe OJ, Olusanya A, Olayemi SO, Akande B. A prospective study of the effect of antihypertensive medications on the sexual functions of hypertensive adult male patients. Future Science OA. 2020 Jun 2;6(6):FSO479. DOI: https://doi.org/10.2144/fsoa-2020-0030
Matchar DB, McCrory DC, Orlando LA, Patel MR, Patel UD, Patwardhan MB, et al. Systematic review: Comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treating essential hypertension. Ann Intern Med 2008;148:16-29. DOI: https://doi.org/10.7326/0003-4819-148-1-200801010-00189
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.