Docking, synthesis and biological evaluation of pyridine ring containing Diaryl urea derivatives as anticancer agents

Vanita Marvaniya; Hirak V. Joshi; Ujashkumar A. Shah; Jayvadan K. Patel; Jimish R. Patel

doi:10.53730/ijhs.v6nS3.6200

Authors

Vanita Marvaniya Research Scholar, Sankalchand Patel University, Visnagar, Gujarat, India
Hirak V. Joshi Faculty of Pharmacy, Sankalchand Patel University, Visnagar, Gujarat, India
Ujashkumar A. Shah Faculty of Pharmacy, Sankalchand Patel University, Visnagar, Gujarat, India
Jayvadan K. Patel Faculty of Pharmacy, Sankalchand Patel University, Visnagar, Gujarat, India
Jimish R. Patel Department of Pharmaceutical Chemistry, Shri B M Shah College of Pharmaceutical Education and Research, College Campus, Dhansura Road, Modasa-383315, Gujarat, India

Keywords:

pyridine, diaryl urea, molecular docking, anticancer, MTT assay

Abstract

A novel series of pyridine ring containing diaryl urea derivatives (R1-R9) were synthesized in four chemical steps using pyridine-2-carboxylic acid as starting material. The synthesized compounds were design by using Autodock vina in the crystal structure of the Kinase domain of Human B-raf (PDB ID: 4DBN) to get insights into structural requirements for anticancer activity. In vitro anticancer activity against cell line (MCF-7) showed that compounds R3, R6 and R9 were found to be the most potent (Docking score: > -12, IC₅₀ = 17.39 µM) among the synthesized molecules.

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