Estimation the relationship between IL-17 and some biochemical parameters in patients with rheumatoid arthritis

Fatima Felaieh Hassan; Athmar Dhahir Muttashar; Eman J. Ali; Fatima K. Aziz; Salma Ismail Abbas

doi:10.53730/ijhs.v6nS4.6315

Authors

Fatima Felaieh Hassan
fatima.alhalaly@gmail.com
Al-Shatrah Hospital, Dhi Qar Health Department, Ministry of Health, Iraq
Athmar Dhahir Muttashar Al-Shattra Hospital, Thi-Qar Health Department, Ministry of Health, Iraq
Eman J. Ali Al-Shattra Hospital, Thi-Qar Health Department, Ministry of Health, Iraq
Fatima K. Aziz Al-Shattra Hospital, Thi-Qar Health Department, Ministry of Health, Iraq
Salma Ismail Abbas Al-Haboubi Hospital, Dhi Qar Health Department, Ministry of Health, Iraq

Keywords:

Rheumatoid arthritis, IL-17, Vitamin D, MDA, GSH

Abstract

Little information is available on the relationship between IL-17 with VD, ESR, MDA and GSH levels for patients with Rheumatoid Arthritis. This study aimed to determine the levels of IL-17, VD, ESR, MDA and GSH, also to determine the relationship between IL -17 with VD, ESR, MDA and GSH. The sample of this study consists of 30 patients and 30 apparently healthy individuals. The results showed that the levels of IL-17, MDA and ESR marked increase in patients group in compare with controls group (P≤0.05).While levels of VD and GSH shows marked decrease in patients group in comparison with the controls group (P≤0.05). It was found positive relationship between IL-17 and levels of MDA and ESR. Also it was found negative correlation between IL-17 and levels of the VD and GSH.

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References

Afzali B, Lombardi G, Lechler RI, Lord GM. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol 2007;148:32–46. DOI: https://doi.org/10.1111/j.1365-2249.2007.03356.x

Ballatori N. Glutathione dysregulation and the etiology and progression of human diseases. Biol. Chem. 2009;390:191–214. DOI: https://doi.org/10.1515/BC.2009.033

Safa Tahmasebi, Mohamed A El‐Esawi, Zaid Hameed Mahmoud, Anton Timoshin, Hamed Valizadeh, Leila Roshangar, Mojtaba Varshoch, Aydin Vaez, Saeed Aslani, Jamshid G Navashenaq, Leili Aghebati‐Maleki, Majid Ahmadi. Immunomodulatory effects of Nanocurcumin on Th17 cell responses in mild and severe COVID‐19 patients, Journal of cellular physiology, 236(7):5325-5338, 2021. DOI: https://doi.org/10.1002/jcp.30233

Chabaud M, Fossiez F, Taupin JL, Miossec P. Enhancing effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines. J Immunol. (1998) 161:409-14.

Chabaud M, Page G, Miossec P. Enhancing effect of IL-1, IL-17, and TNF-alpha on macrophage inflammatory protein-3alpha production in rheumatoid arthritis: regulation by soluble receptors and Th2 cytokines. J Immunol. (2001) 167:6015–20. DOI: https://doi.org/10.4049/jimmunol.167.10.6015

Chabaud M, Garnero P, Dayer JM, Guerne PA, Fossiez F, Miossec P. Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis. Cytokine. (2000) 12:1092–9. DOI: https://doi.org/10.1006/cyto.2000.0681

Chabaud M, Durand JM, Buchs N, Fossiez F, Page G, Frappart L, et al. Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum. (1999) 42:963-70 DOI: https://doi.org/10.1002/1529-0131(199905)42:5<963::AID-ANR15>3.0.CO;2-E

Ellman, G. L. Tissue sulfhydryl groups.Archeves Biochemistry and biophysics, 1959 82, 70-77. DOI: https://doi.org/10.1016/0003-9861(59)90090-6

Grossman, E.Does increased oxidative stress cause hypertension? Diabetes Care, 2008, 31(Suppl 2), S185–S189. DOI: https://doi.org/10.2337/dc08-s246

Hanan M. Al-Saadany a, Manal S. Hussein a, Rasha A. Gaber b, Hossam A. Zaytoun c Th-17 cells and serum IL-17 in rheumatoid arthritis patients: Correlation with disease activity and severity, The Egyptian Rheumatologist (2015). DOI: https://doi.org/10.1016/j.ejr.2015.01.001

Hirani, V. (2012) Vitamin D status and pain: analysis from the Health Survey for England among English adults aged 65 years and over. Br J Nutr 107: 1080–1084. DOI: https://doi.org/10.1017/S0007114511003965

Hewison M. (2012) Vitamin D and immune function: autocrine, paracrine or endocrine? Scand J Clin Lab Invest Suppl 243: 92–102.

Hemdan NY, Birkenmeier G, Wichmann G, Abu El-Saad AM, Krieger T, Conrad K, et al. Interleukin-17-producing T helper cells in autoimmunity. Autoimmun Rev 2010;9:785–92. DOI: https://doi.org/10.1016/j.autrev.2010.07.003

Ifigenia Kostoglou-Athanassiou, Panagiotis Athanassiou, Aikaterini Lyraki, Ioannis Raftakis and Christodoulos Antoniadis , Vitamin D and rheumatoid arthritis Ther Adv Endocrinol Metab (2012) 3(6) 181– 187. DOI: https://doi.org/10.1177/2042018812471070

Kim SK, Bae J, Lee H, Kim JH, Park S-H, Choe J-Y. Greater prevalence of seropositivity for anti-cyclic citrullinated peptide antibody in unaffected first-degree relatives in multicase rheumatoid arthritis-affected families. Korean J Intern Med. 2013;28(1):45-53. DOI: https://doi.org/10.3904/kjim.2013.28.1.45

Kim, T., Choi, S., Lee, Y., Song, G. and Ji, J. (2012) Combined therapeutic application of mTOR inhibitor and vitamin D(3) for inflammatory bone destruction of rheumatoid arthritis. Med Hypotheses 79: 757–760. DOI: https://doi.org/10.1016/j.mehy.2012.08.022

LequinR.(2005).Enzyme immunoassay(EIA) /Enzyme immunosorbent assay (ELISA). clin.chem.,51(12):2415-2418. DOI: https://doi.org/10.1373/clinchem.2005.051532

Lu S.C. Glutathione synthesis. Biochim. Biophys. Acta. 2013;1830(5):3143–3153. DOI: https://doi.org/10.1016/j.bbagen.2012.09.008

Muslih, R. D. , Al-Nimer, M. A. and Al-Zamely, O. M. 2002. “The Level of Malondialdehyde after Activation with H2O2 and CuSO4) and Inhibited by Desferoxamine and Molsidomine in the Serum of Patients with Acute Myocardial Infection.” Nat. J. Chem 5: 148–49.

M. Q. Hassan,1 R. A. Hadi,2 Z. S. Al-Rawi,3 V. A. Padron4 and S. J. Stohs, The Glutathione Defense System in the Pathogenesis of Rheumatoid Arthritis J. Appl. Toxicol 2001. 21, 69–73. DOI: https://doi.org/10.1002/jat.736

Mora J.R., Iwata M., von Andrian U.H. (2008) Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol 8: 685–698. DOI: https://doi.org/10.1038/nri2378

Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005;6:1133–41. DOI: https://doi.org/10.1038/ni1261

Robinson Brittanie, Munjal Shalok, Agostino Justin D., Venketaraman Vishwanath. Liposomal-Glutathione as a potential therapeutic agent to control HIV-1 infection and tubervulosis. Eur. Med. J. 2018;3(4):62–69.

Schulze-Koops H, Kalden JR. The balance of Th1/Th2 cytokines in rheumatoid arthritis. Best Pract Res Clin Rheumatol 2001;15:677–91. DOI: https://doi.org/10.1053/berh.2001.0187

Song, G., Bae, S. and Lee, Y. (2012) Association between vitamin D intake and the risk of rheumatoid arthritis: a meta-analysis. Clin Rheumatol 2 September [Epub ahead of print]. DOI: https://doi.org/10.1007/s10067-012-2080-7

Scott LJ. Tofacitinib: a review of its use in adult patients with rheumatoid arthritis. Drugs. 2013;73(8):857-874. DOI: https://doi.org/10.1007/s40265-013-0065-8

Weiss S. (2011) Bacterial components plus vitamin D: the ultimate solution to the asthma (autoimmune disease) epidemic? J Allergy Clin Immunol 127: 1128–1130. DOI: https://doi.org/10.1016/j.jaci.2011.02.025

Zhang C, Zhang J, Yang B, Wua C. Cyclosporin A inhibits the production of IL-17 by memory Th17 cells from healthy individuals and patients with rheumatoid arthritis. Cytokine 2008;42:345–52. DOI: https://doi.org/10.1016/j.cyto.2008.03.006