Moringa oleifera: A review of phytochemicals constituents and medicinal properties as a future source of new drugs

Jyoti Rathore; Chinmoyee Rani Das

doi:10.53730/ijhs.v6nS1.6471

Authors

Jyoti Rathore Research Scholar, Atal Bihari Vajpayee Vishwavidyalaya,Bilaspur 495001 (C.G.)
Chinmoyee Rani Das Department of Chemistry, Dr.J.P.Mishra Govt.Science College Mungeli, 495334 Bilaspur(C.G.)

Keywords:

Moringa oleifera, medicinal plants, phytochemicals constituents, pharmacological activities

Abstract

Moringa oleifera Lam (Moringaceae) is a highly desired plant that can be found in a variety of tropical and subtropical environments. The leaves, roots, seed, bark, and flower of this plant have anticancer, antipyretic, antiepileptic, anti-inflammatory, antiulcer, and antibacterial properties, and are used in indigenous medicine, especially in underdeveloped nations, to treat a number of maladies.The goal of this review is to give thorough information on the phytochemical compounds and pharmacological activities of Moringa oleifera, a therapeutic plant. The information provided in this study will be valuable in future investigations aimed at developing a revolutionary therapeutic medicine.

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References

Ullah et al., 2020;Ageel et al., 1986;Gamal et al., 2010 Purena et al.,2018

Varahachalam et al., 2021;Paliwal et al., 2020

Leone et al.,2015

Altemimi, A.; Lakhssassi, N.; Baharlouei, A.; Watson, D.G.Phytochemical: extraction,isolation, and identification of bioactive compounds from plant extracts.Plants 2017, 6, https://doi.org/10.3390/plants6040042.

Bennett,R.N.,Mellon,F.A.,Foidl,N.,Pratt,J.H.,Du pont,M.S.,Per kins,L.and Kroon,P.A.Profiling glucosinolates and phenolics in vegetative and reproductive tissues of the multi-purpose trees Moringa oleifera L. and Moringa stenopetala L.J Agric Food Chem 51(12),2003,3546-3553.

Saluja,M.P.,Kapil,R.S. and Popli,S.P.Studies in medicinal plants:Part VI Chemical constituents of Moringa oleifera Lam. And Isolation of 4-Hydroxymellein.Indian J Chem 16 B,1978,1044-1045.

PrasadRajbhar,Y.;Rajbhar,G.;Rawat,P.L.;Shukla,S.;Kumar,M.;Grow Moringa oleifera), the miracle tree on the earth. HortInt J 2018,2,166-172,http://doi.org/10.15406/hij.2018.02.00047.

Faizi,S.;Siddiqui,B.S.; Saleem,R.;Aftab,K.;Shaheen,F.;Gilani,A.U.H.Hypotensive constituents from the pods of Moringa oleifera.Planta Med 1998,64,225-228,http://doi.org/10.10.1055/s

Bhattacharya,S.B.,Das,A.K. and Banerji,N.Chemical investigations on the gum exudates from Sajna(Moringaoleifera)Carbohydr Res 102,1982,253-262.

Khare,G.C.,Singh,V.and Gupta,P.C.1997.A new Leucoanthocyanin from Moringa oleifera Gum. J Indian Chem Soc 74, 1997,247-248

Faizi,S.,Siddiqui,B.S.,Saleem,R.,Siddiqui,S. and Aftab,K.Isolation and structure elucidation of new nitrile and mustard oil glycosides from Moringa oleifera and their effect on blood pressure.J Nat Prod 57(9),1994,1256-1261.

Faizi,S.,Siddiqui,B.S.,Saleem,R.,Siddiqui,S. and Aftab,K. and Gilani,A.H.Fully acetylated carbamate and hypotensive thiocarbamate glycosides from Moringa oleifera.Phytochemistry 38(4),1995,957-963.

Waterman,C.;Cheng,D.M.;Rojas-Silva,P.;Poulev, A.; Dreifus, J.; Lila, M.A.; Raskin extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro.Phytochemistry 2014,103,114-122,https://doi.org/10.1016/j.phytochem.2014.03.028.)

(Fahey,J.W.; Olson,M.E.; Stephenson,K.K.;Wade, K.L.; Chodur,G.M.;Odee, D.; Nouman,W.;Massiah, M.; Alt, J.;Egner, P.A.;Hubbard, W.C. The diversity of chemoprotective glucosinolates in Moringaceae(Moringa spp.). Sci Rep 2018,8,1-14,https://doi.org/10.1038/s41598-018-26058-4.)

R.N.Bennett, F.A. Mellon, N. Foidl,J.H. P ratt, M.S. Dupont, L.Perkins, P.A. Kroon. J Agric Food Chem.2003,51(12),3546-3553.

Shikha Khandelwal and S.M.Paul Khurana(2019) Molecular docking studies and GC-MS analysis of the antimicrobial compounds isolated from leaves of Moringa oleifera.Indian Journals.com,11:95-103

Richard N.Bennett.;Fred A.Mellon.; Nikolaus Foidl.;John H.Pratt.;M. Susan Dupont.; Lionel Perkins.;Paul A.Kroon.;Profiling Glucosinolates and Phenolics in Vegetative and Reproductive Tissues of the Multi-Purpose Trees Moringa oleifera L(Horseradish Tree) and Moringa stenopetala L.Journal of Agriculture and food Chemistry,51,3546-3553.

Nitesh Bhalla.;Nitin Ingle.;Srilakshmi V.Patri.;D.Haranath.;Phytochemical analysis of Moringa Oleifera leaves extracts by GC-MS and free radical scavenging potency for industrial applications.;Saudi Journal of Biological Science 28,6915-6928.

Imran,M.;Salehi,B;Sharifi.Rad,J.;Gondal,T.A.;F.Saeed,F.;Imran,A,;Shahbaz,M.;Fokou,P.V.T.;Arshad,M.U.;Khan,H.;Guerreiro,S.G.;Martins,N.;Estevinho, L.M. Kaempferol : A key emphasis to its anticancer potential. Molecules 2019,24,1-16,https://doi.org/10.3390/molecules24122277.

Biswas,D.;Nandy,S.;Mukherjee, A.; Pandey,D.K.; Dey,A. Moringa oleifera Lam. And derived phytochemicals as promising antiviral agents, A review. S Afr J Bot 2020, 129, 272-282, https://doi.org/10.1016/j.sajb.2019.07.049.

Lam, M.; Kou,X.; Li, B.; Olayanju, J.B.;D rake, J.M.;Chen, N.Nutraceutical or pharmacological potential of Moringa oleifera Lam. Nutrients 2018,10,https://doi.org/10.3390/nu 10030343.

Popoola, J.O.; Aworunse, O.S.; Oyesola, O.L.; Akinnola, O.O.; Obembe, O.O. A systematic review of pharmacological activities and safety of Moringa oleifera. J HerbmedPharmacol 2020,9, 174-190, https://doi.org/10.34172/jhp.2020.24.

Memon,G.M.,Memon, S.A. and Memon,A.R.Isolation and structure elucidation of moringyne,a new glycoside from the seeds of Moringa oleifera. Pak J Sci Ind Res 28(1),1985,7-9

Caceres,A.,Saravia,A.,Rizzo,S.,Zabala, L., De Leon, E. and Nave,F.Pharmacological properties of Moringa oleifera 2: Screening for antispasmodic,anti-inflammatory and diuretic activity.J Ethnopharmacol 36(3),1992,233-237.

Lalas,S. and Tsaknis,J.Extraction and identification of natural antioxidant from the seeds of the Moringa oleifera tree variety of Malawi.J Am Oil Chemists Soc 79(7),2002, 677-683.

Caceres,A.,Cebreva,O.,Morales,O.,Miollinedo,P.and Mendia,P.Pharmacological properties of Morings oleifera: Preliliminary screening for antimicrobial activity.J Ethnopharmacol 33(3),1991,213-216.

Limaye,D.A.,Nimbakar.A.Y.,Jain.R.and Mansoor,A.Cardiovascullar effects of aqeous extract of Moringa pterygosperma.Phytother Res 9(1),1995,37-40.

Ghasi,S.,Nwobodo,E. and Ofili,J.O. Hypocholesterolemic effects of crude extract of leaf of Moringa oleifera Lam.In high fat diet fed wistar rats.J Ethnopharmacol 69(1), 2000,21-25

Gupta,M.,Mazumdar,U.K. and Chakrabarti,S.CNS activities of methanolic extract extract of Moringa oleifera root in mice.Fitoterapia 70(3),1999,244-250.

Prakash,A.O.,Tewari,R.K.,Shukla,S.andTewati,K.K.Post-coital antifertility effect of some medicinal plants in rats.Indian Drugs 25(2),1987,40-44.

Guevara,A.P.,Vargas,C.,C.,Sakurai,Fuziwara,Y.,Hashimoto,K. and Maoka,T.an anti-tumor promoter from Moringa oleifera Lam.Mutation Res 440(2),1999,181-188.

Shanmugavel,G.;Prabakaran,K.;George,B.EvaluationofphytochemicalconstituentsofMoringaoleifera(Lam.)leaves collected fromPuducherryregion,South India. IntJZool ApplBiosci2018,3,1–8.

Ruckmani,K.,Kacimani,S.,Anandan,R.and Jaykar,B.Effect of Moringa oleifera Lam.On paracetamol induced hepatotoxicity. Indian J Pharm Sci 60(1),1998,33-35.

Pal,S.K.,Mukherjee,P.K.and Saha,B.P. Studies on the antiulcer activity of Moringa oleifera leaf extract on gastric ulcer models in rats.Phytother Res 9(6),1995,463-465.

Bamagous, G.A.; Al Ghamdi, S.S.; Abdel,I.; Ibrahim, A.; Mahfoz, A.M.; Afify, M.A. Antidiabetic andantioxidant activity of ethyl acetate extract fraction of Moringa oleifera leaves in streptozotocin-induceddiabetes rats via inhibition of inflammatory mediators. Asian Pac J Trop Biomed 2018, 8, 320–327,https://doi.org/10.4103/2221-1691.235327.

Shanmugavel,G.;Prabakaran,K.;George,B.EvaluationofphytochemicalconstituentsofMoringaoleifera(Lam.)leaves collected fromPuducherry Region, SouthIndia.Int JZoolAppl Biosci2018,3, 1–8.

Toma, A.; Deyno, S. Phytochemistry and pharmacological activities of Moringa oliefera. Int J Pharm SciRes2013,1, 222–231.

Prabakaran, M.; Kim, S.; Sasireka, A.; Chandrasekaran, M. Polyphenol composition and antimicrobialactivity of various solvent extracts from different plant parts of Moringa oleifera. Food Biosci2018, 26,23–29,https://doi.org/10.1016/j.fbio.2018.09.003.

Isitua, C.C.; Ibeh, I.N.; Olayinka, J.N. In vitro antifungal activity of Moringa oleifera Lam leaf on someselectedclinical fungal strains. Indian J Appl Res2016, 6,548–552.

Anitha, P.; Sakthivel, P.; Balamurugan, S.; Muruganantham, N.; Senthamilselvi, M.M. Pharmacologicalactivityofsilver nanoparticlesusingMoringaoleiferaflowerextracts. JInf ComputSci202010,224–235.

Suresh, S.; Su, A.; Gupta, M.; Lalotra, S.; Sisodia, S.S.; Baksi, R.; Nivsarkar, M. Phytochemical analysisand pharmacological evaluation of methanolic leaf extract of Moringa oleifera Lam in ovalbumin inducedallergicasthma. S Afr JBot2020,30, 484–493,https://doi.org/10.1016/j.sajb.2020.01.046.

Tshabalala,T.;Ndhlala,A.R.;Ncube,B.;Abdelgadir,H.A.;VanStaden,J.Potentialsubstitutionoftherootwith the leaf in the use of Moringa oleifera for antimicrobial, antidiabetic and antioxidant properties. S AfrJBot2020,129, 106–112,https://doi.org/10.1016/j.sajb.2019.01.029.