Analysis of possible antidepressant effects of Cordia Myxa extract in male rats: Behavioral study

Yasser Jasib Habeeb; Selman Mohammed Selman; Alaa Jeafer Mahrath

doi:10.53730/ijhs.v6nS2.6512

Authors

Yasser Jasib Habeeb
yasserelyassery@gmail.com
Department of Pharmacology, College of Medicine, University of Babylon, Babel, Iraq
Selman Mohammed Selman Department of Pharmacology, College of Medicine, University of Babylon, Babel, Iraq
Alaa Jeafer Mahrath Department of Biochemistry, college of medicine, University of Babylon, Babel, Iraq

Keywords:

chronic mild stress, depression, cordia myxa, groomings, line croosings

Abstract

Depression is one of the most frequent psychiatric illnesses, and it is treated with a number of drugs that have serious side effects on human health and lead to a rise in suicide rates. Due to their safety, efficacy, and cost-effectiveness, herbal drugs have lately sparked a lot of interest in the treatment of depression. As a result, the goal of this study was to see how C.Myxa fruit extract affected a model of chronic unexpected stress (CUS). Six groups of sixty male rats were formed as a result. Group 1 (control) was not exposed to CUMS and did not receive any treatment, whereas group 2 was exposed to CUMS for 24 days and received normal saline treatment for 14 days, group 3 was exposed to CUMS for 24 days and received 10 mg/kg fluoxetine daily on day 10 for 14 days, and groups 4,5 and 6 were exposed to CUMS for 24 days and received C.Myxa extract (125, 250, and 500 mg/kg respectively) on day 10 for 14 days. Open field test groomings and line crossing frequency were used to assess the antidepressant impact of fluoxetine and C.Myxa extract.

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References

E. Jaddoa, “Analysis of rat brain lipids and metabolites after antidepressant drug treatment Analysis of rat brain lipids and metabolites after antidepressant drug treatment,” no. April, 2018.

J. F. Cryan, R. J. Valentino, and I. Lucki, “Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test,” Neurosci. Biobehav. Rev., vol. 29, no. 4–5, pp. 547–569, 2005, doi: 10.1016/j.neubiorev.2005.03.008.

A. Bajpai, A. K. Verma, M. Srivastava, and R. Srivastava, “Oxidative stress and major depression,” J. Clin. Diagnostic Res., vol. 8, no. 12, pp. CC04–CC07, 2014, doi: 10.7860/JCDR/2014/10258.5292.

M. Shen et al., “L-theanine ameliorate depressive-like behavior in a chronic unpredictable mild stress rat model via modulating the monoamine levels in limbic–cortical–striatal–pallidal–thalamic-circuit related brain regions,” Phyther. Res., vol. 33, no. 2, pp. 412–421, 2019, doi: 10.1002/ptr.6237.

A. Aberoumand and S. S. Deokule, “Determination of elements profile of some wild edible plants,” Food Anal. Methods, vol. 2, no. 2, pp. 116–119, 2009, doi: 10.1007/s12161-008-9038-z.

S. Salimimoghadam, A. Ashrafi, F. Kianidehkordi, and H. Najafzadehvarzi, “Hypoglycemic, Antitussive and Analgesic Effects of Nanoparticles of Cordia myxa Fruits Extract,” Int. J. Pharm. Investig., vol. 9, no. 4, pp. 205–209, 2019, doi: 10.5530/ijpi.2019.4.38.

M. Shahriari and D. Moghadamnia, “Protective effect of cordia myxa extract on changes in body weight, serum proteins, albumin and liver histology of adult male rats induced by cadmium chloride toxicity,” Iran. J. Toxicol., vol. 13, no. 2, pp. 43–49, 2021, doi: 10.32598/IJT.13.2.575.3.

M. Gazal et al., “Antidepressant-like effects of aqueous extract from Cecropia pachystachya leaves in a mouse model of chronic unpredictable stress,” Brain Res. Bull., vol. 108, pp. 10–17, 2014, doi: 10.1016/j.brainresbull.2014.07.007.

A. Sequeira-Cordero, A. Salas-Bastos, J. Fornaguera, and J. C. Brenes, “Behavioural characterisation of chronic unpredictable stress based on ethologically relevant paradigms in rats,” Sci. Rep., vol. 9, no. 1, pp. 1–21, 2019, doi: 10.1038/s41598-019-53624-1.

S. C. Dulawa, K. A. Holick, B. Gundersen, and R. Hen, “Effects of chronic fluoxetine in animal models of anxiety and depression,” Neuropsychopharmacology, vol. 29, no. 7, pp. 1321–1330, 2004, doi: 10.1038/sj.npp.1300433.

S. S. Valvassori, R. B. Varela, and J. Quevedo, Animal Models of Mood Disorders: Focus on Bipolar Disorder and Depression, Second Edi. Elsevier Inc., 2017.

Y. Zhang et al., “Optimized animal model to mimic the reality of stress-induced depression in the clinic,” BMC Psychiatry, vol. 17, no. 1, pp. 1–9, 2017, doi: 10.1186/s12888-017-1335-x.

D. Wang, S. C. An, and X. Zhang, “Prevention of chronic stress-induced depression-like behavior by inducible nitric oxide inhibitor,” Neurosci. Lett., vol. 433, no. 1, pp. 59–64, 2008, doi: 10.1016/j.neulet.2007.12.041.

A. Pałucha-Poniewiera, K. Podkowa, A. Rafało-Ulińska, P. Brański, and G. Burnat, “The influence of the duration of chronic unpredictable mild stress on the behavioural responses of C57BL/6J mice,” Behav. Pharmacol., vol. 31, no. 6, pp. 574–582, 2020, doi: 10.1097/FBP.0000000000000564.

R. Banerjee, S. Hazra, A. K. Ghosh, and A. C. Mondal, “Chronic administration of bacopa monniera increases BDNF protein and mRNA expressions: A study in chronic unpredictable stress induced animal model of depression,” Psychiatry Investig., vol. 11, no. 3, pp. 297–306, 2014, doi: 10.4306/pi.2014.11.3.297.

J. S. Knutson, “基因的改变NIH Public Access,” Bone, vol. 23, no. 1, pp. 1–7, 2014, [Online]. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624763/pdf/nihms412728.pdf.

D. Liu et al., “Histone acetylation and expression of mono-aminergic transmitters synthetases involved in CUS-induced depressive rats,” Exp. Biol. Med., vol. 239, no. 3, pp. 330–336, 2014, doi: 10.1177/1535370213513987.

G. H. Aljeboury, “Anti-Inflammatory Effect of Cordia Myxa Extract on Bacteria that Infected Wounds in Rats as a Model for Human,” vol. 25, no. 4, pp. 16040–16045, 2021.