Role of human papillomavirus in the pathogenesis of oral lichen planus: A systematic review

Aswathy K. Vijayan; Arvind Muthukrishnan; Aparna M. Nair; Shiana Jo

doi:10.53730/ijhs.v6nS2.6532

Authors

Aswathy K. Vijayan
aswathykvijayan4@gmail.com
Reader, Department of Oral Medicine and Radiology, PMS College of Dental Science and Research, Vattapara, Thiruvananthapuram, India
Arvind Muthukrishnan Professor and Head, Department Of Oral Medicine and Radiology, Saveetha Dental College and Hospital, Saveetha Institute Of Medical and Technical Sciences, Saveetha University, Chennai, India
Aparna M. Nair Reader, Department of Periodontics, PMS College of Dental Science and Research, Vattapara, Thiruvananthapuram, India
Shiana Jo Assistant Professor, Department of Oral Medicine and Radiology, PMS College of Dental Science and Research, Vattapara, Thiruvananthapuram, India

Keywords:

HPV, OLP, DNA, oral cavity, premalignant lesion

Abstract

Oral Lichen Planus (OLP) is a chronic inflammatory disease with a cell-mediated immunopathologic response. Although OLP has been studied extensively for decades, its exactaetiologyremains unclear. Autoimmunity, viruses like Hepatitis C Virus (HCV), Human Papillomavirus (HPV), and stress have all beenhypothesized in recent articles. HPVs are epitheliotropic viruses with an affinity for keratinocytes and are principally found in the anogenital tract, urethra, skin, larynx, tracheobronchial and oral mucosa. This article aimed to review the frequency of HPV prevalence in OLP. A computer database search was performed through the use of PubMed from 1987 to 2021. The summary showed that the association of HPV and OLP varied significantly by geographic population. The correlation of HPV and erosive-atrophic oral lichen planus was comparable and well above that of HPV and non-EA-OLP. Among HPV genotypes, HPV 16 showed an extremely strong association with OLP, and HPV 18 showed a relatively strong one.

Downloads

Download data is not yet available.

References

Pindborg JJ, Reichart PA, Smith CJ, Sobin LH. WHO International Histological Classification of Tumors: Histological Typing of Cancer and Precancer of the Oral Mucosa. Berlin: Springer; 1997.

Miller CS, Epstein JB, Hall EH, Sirois D. Changing oral care needs in the United States: the continuing need for oral medicine. Oral Surg Oral Med Oral Pathol Oral RadiolEndod 2001;91:34- 44.

Silverman S, Gorsky M, Lozada-Nur F. A prospective follow-up study of 570 patients with oral lichen planus: persistence, remission, and malignant association. Oral Surg Oral Med Oral Pathol 1985;60:30-4.

Gorsky M, Raviv M, Moskona D, Laufer M, Bodner L. Clinical characteristics and treatment of patients with oral lichen planus in Israel. Oral Surg Oral Med Oral Pathol Oral RadiolEndod 1996;82:644-9.

Szarka K, Tar I, Feher E, Gall T, Kis A, Toth ED, et al. Progressive increase of human papillomavirus carriage rates in potentially malignant and malignant oral disorders with increasing malignant potential. Oral Microbiol Immunol. 2009; 24(4):314–8.

van der Meij EH, van der Waal I. Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications. J Oral Pathol Med 2003;32:507–12.

van der Meij EH, Mast H, van der Waal I. The possible premalignant character of oral lichen planus and oral lichenoid lesions: a prospective five-year follow-up study of 192 patients. Oral Oncol 2007;43:742–8

Campisi G, Panzarella V, Giuliani M, Lajolo C, Di Fede O, Falaschini S, et al. Human papillomavirus: Its identity and controversial role in oral oncogenesis, premalignant and malignant lesions (review). Int J Oncol 2007;30:813‐23.

Arirachakaran P, Chansaengroj J, Lurchachaiwong W, Kanjanabud P, Thongprasom K, Poovorawan Y. Oral lichen planus in that patients have a low prevalence of human papillomavirus. ISRN Dent. 2013; 2013:362750.

Sahebjamiee M, SandL, KarimiS, Jalil Momen et al J Oral MaxillofacPathol 2015 May-Aug; 19(2): 170–174.

Giovannelli L, Campisi G, Colella G, Capra G, Di Liberto C, Caleca MP, et al. Brushing of oral mucosa for diagnosis of HPV infection in patients with potentially malignant and malignant oral lesions. Mol Diagn Ther. 2006; 10(1):49–55.

Giovannelli L, Campisi G, Lama A, Giambalvo O, Osborn J, Margiotta V, et al. Human papillomavirus DNA in oral mucosal lesions. J Infect Dis. 2002; 185(6):833–6.

Maitland NJ, Cox MF, Lynas C, Prime SS, Meanwell CA, Scully C. Detection of human papillomavirus DNA in biopsies of human oral tissue. Br J Cancer. 1987; 56(3):245–50.

Debanth S, Singh PA, Mehrotra R, Singh M, Gupta SC, Pandya S, et al. Human papillomavirus infection and premalignant lesions of the oral cavity: A cross-sectional study in Allahabad, North India. Asia- Pac J Clin Oncol. 2009; 5(2):111–8.

OFlatharta C, Flint SR, Toner M, Butler D, Mabruk MJ. Investigation into a possible association between oral lichen planus, the human herpesviruses, and the human papillomaviruses. Mol Diagn. 2003; 7(2):73–83.

Sand L, Jalouli J, Larsson PA, Hirsch JM. Human papillomaviruses in oral lesions. Anticancer Res. 2000; 20(2B):1183–8.

Razavi SM, Ghalayani P, Salehi MR, Attarzadeh H, Shahmoradi M. Humanpapillomaviruss as a possible factor in the pathogenesis of oral lichen planus. Dent Res J (Isfahan). 2009; 6(2):82–6.

Sameera A, Kotikalpudi R, Patel RK, et al. Molecular detection of human papillomavirus DNA in oral lichen planus patients. J Clin Diagn Res 2019;13:Zc20-4.

Mattila R, Rautava J, Syrjänen S. Human papillomavirus in oral atrophic lichen planus lesions. Oral Oncol. 2012;48:980-84.

Pol CA, Ghige SK, Gosavi SR. Role of human papilloma virus-16 in the pathogenesis of oral lichen planus—an immunohistochemical study. Int Dent J. 2015; 65(1):11–4.

Yildirim B, Senguven B, Demir C. Prevalence of herpes simplex, Epstein Barr and human papillomaviruses in oral lichen planus. Med Oral Patol Oral Cir Bucal. 2011; 16(2):e170–4.

Harden me, Karlmunger k. Human papillomavirus molecular biology. Mutat Res Rev Mutat Res 2017; 772: 3– 12.

De Villiers EM, Fauquet C, Broker TR, Bernard HU, ZurHausen H. Classification of papillomaviruses. Virology 2004;324:17–27.

Bernard HU, Burk RD, Chen Z, Van Doorslaer K, Hau- sen H, DE Villiers EM. Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments. Virology 2010; 401: 70–79.

Bernard HB. Regulatory elements in the viral genome. Virology 2013; 445: 197–204.

Weissenborn SJ, DE Koning MN, Wieland U, Quint WG, Pfister HJ. Intrafamilial transmission and family-specific spectra of cutaneous beta-papillomaviruses. J Virol 2009; 83: 811–816.

Ragin C, Edwards R, Larkins‐Pettigrew M, Taioli E, Eckstein S, Thurman N, et al. Oral HPV infection and sexuality: A cross‐sectional study in women. Int J Mol Sci 2011;12:3928‐40.

Kreimer AR, Alberg AJ, Daniel R, Gravitt PE, Viscidi R, Garrett ES, et al. Oral human papillomavirus infection in adults is associated with sexual behaviour and HIV serostatus. J Infect Dis 2004;189:686‐98.

D’Souza G, Wentz A, Kluz N, Zhang Y, Sugar E, Youngfellow RM, Guo Y, Xiao W, Gillison ML. Sex differences in risk factors and natural history of oral human papillomavirus infection. J Infect Dis 2016; 213: 1893–1896.

Syrjänen S, Lodi G, von Bültzingslöwen I, Aliko A, Arduino P, Campisi G, et al. Human papillomaviruses in oral carcinoma and oral potentially malignant disorders: A systematic review. Oral Dis 2011;17 Suppl 1:58‐72.

Parsons RJ, Kidd JG. Oral papillomatosis of rabbit: a virus disease. J Exp Med 1943; 77: 233–250.

32.Young SK, Min KW. In situ DNA hybridization analysis of oral papillomas, leukoplakias, and carcinomas for human papilloma- virupapillomaviruss. Oral Surg Oral Med Oral Pathol 1991;71:726-9

Cox M, Maitland N, Scully C. Human herpes simplex-1 and papillomavirus type 16 homologous DNA sequences in normal, potentially malignant and malignant oral mucosa. Oral Oncol 1993;29B:215-9.

Miller CS, Johnstone BM. Human papillomavirus as a risk factor for oral squamous cell carcinoma: A meta‐analysis, 1982‐1997. Oral Surg Oral Med Oral Pathol Oral RadiolEndod 2001;91:622‐35.

Khovidhunkit SO, Buajeeb W, Sanguansin S, Poonsawat S, Weerapradist W. Detection of human papillomavirus in oral squamous cell carcinoma, leukoplakia and lichen planus in Thai patients. Asian Pac J Cancer Prev. 2008;4:771-75.

Braakhuis BJ, Brakenhoff RH, Meijer CJ, Snijders PJ, Leemans CR. Human papilloma virus in head and neck cancer: The need for a standardised assay to assess the full clinical importance. Eur J Cancer 2009;45:2935‐9.

Ma J, Zhang J, Zhang Y, et al. The magnitude of the association between human papillomavirus and oral lichen planus: a meta-analysis. PLoS One 2016;11:e0161339.

Smith EM, Ritchie JM, Summersgill KF, Hoffman HT, Wang DH, Haugen TH, et al. Human papillomavirus in oral exfoliated cells and risk of head and neck cancer. J Natl Cancer Inst 2004;96:449‐55.

Lodi G, Scully C, Carrozzo M, Griffiths M, Sugerman PB, Current TK. Controversies in oral lichen planus: report of an international consensus meeting. Part 2. Clinical management and malignant transformation. Oral Surg Oral Med Oral Pathol Oral RadiolEndod 2005;100:164-78.