Synthesis of Novel Quinazolin-4-one hybrids as potential antimicrobial agents

Yogesh Kumar Lawaniya; Pradeep Kumar Goyal

doi:10.53730/ijhs.v6nS2.6573

Authors

Yogesh Kumar Lawaniya
yogeshlawaniya1984@gmail.com
Bhupal Noble's Institute of Pharmaceutical Sciences, Bhupal Nobles’, University, Udaipur -313001, India
Pradeep Kumar Goyal Bhupal Noble's Institute of Pharmaceutical Sciences, Bhupal Nobles’, University, Udaipur -313001, India

Keywords:

isoquinolines, N-acyl anthranilamides, potential antimicrobial

Abstract

We have developed an effortless and extremely efficient procedure for the synthesis of quinazolin-4-one derivatives via palladium-catalyzed C-Ccoupling of aryl amide with isocyanides. The reactions are operationally simple and avoid using toxic carbon monoxide and acid chloride, which must be used in an anhydrous system. The structure of the novel compounds was confirmed based on spectral data. We also demonstrated the biological potential of these compounds as novel Antifungal Activity. Based on the MIC results, the most active is 3g.

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References

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