A comparative study on visual evoked potential (VEP) wave P100 latency in hypothyroid and euthyroid individuals
Keywords:
comparative study, evoked potential, hypothyroid, euthyroidAbstract
Hypothyroidism is classified as congenital and acquired according to the time of onset. Consequences of thyroid gland dysfunction also depend on the life stage at which they occur. Peripheral and central nervous system dysfunction are important clinical features of congenital as well as acquired hypothyroidism. Although thyroid hormone effects on the brain are most prominent in development, also in adult-acquired hypothyroidism symptoms such as sensory impairments, disagreeable smells and taste, slowness of thought and action, changes of speech, irritability, headaches ,sleep disturbances, confusion up to delusions and Hallucinations, impairments of memory, of vision as well as of hearing frequently occur. The most prominent and first significant clinical symptom to develop in hypothyroidism is a slowing of speech and of visual perception. These findings indicate CNS involvement in hypothyroidism. VEP may be a useful test to detect these changes in early stage of disease.
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References
Unnikrishnan AG, Menon UV. Thyroid disorders in India:An epidemiological perspective. Indian J EndocrMetab 2011;15:S78-81.
Unnikrishnan AG, Kalra S, Sahay RK, Bantwal G, John Tewari N. Prevalence of hypothyroidism in adults: An epidemiological study in eight cities of India. Indian J EndocrMetab 2013;17:647-52
Karalı E, Güçlü E. Assessment of auditory brainstem responses in hypothyroidism and hyperthyroidism. J Clin Anal Med 2018;9(5): 411-5.
Davis JD, Tremont G. Neuropsychiatric aspects of hypothyroidism and treatmentreversibility. Minerva Endocrinol 2007; 32(1):49–65
Kowsalya V. et al. Electrophysiological changes on brainstem auditory evoked potentials in hypothyroid patients. Journal of Pharmacy Research 2011;4(8):2856-2859
B. Nazlıel et al. Pattern visual evoked potential (PVEP) evaluation in hypothyroidism. J. Endocrinol. Invest. 2002; 25: 955-958.
Gautam V, Paudel BH, Lamsal M, Agrawal K, Jha MK, Maharjan S, et al. Visual evoked potentials’ responses in hypothyroidism and hyperthyroidism. Int J Res Med Sci 2019;7:1589-93.
Mishra UK, Kalita J. Clinical Neurophysiology. Third Edition; 2004 Elsevier; New Delhi:283-308.
Thompson DA, Fritsch DM, Hardy SE. The changing shape of the ISCEV standard pattern onset VEP. Doc Ophthalmol. 2017;135(1):69-76.
Mishra UK, Kalita J. Brainstem auditory evoked potential.In: Binnie CD, Cooper R, Mauguiere F, Osselton J, Prior PF,Tedman BM, editors. Clinical Neurophysiology. 2nd ed.New Delhi: Elsevier; 2004. p. 329-45.
Ozata M, Ozkardes A, Corakci A, Gundogan MA. Subclinical hypothyroidism does not lead to alterations either in peripheral nerves or in brainstem auditory evoked potentials (BAEPs). Thyroid 1995;5:201-5.
Sharma K, Behera JK, Kumar N, Sood S, Madan HS, Das S. Brainstem evoked potential in newly diagnosed patients of subclinical hypothyroidism. North Am J Med Sci 2015;7:131-4.
V.Gowri. Evaluation of visual evoked potentials in type II diabetes mellitus subjects attending a tertiary care hospital. International Journal of Research in Medical Sciences 2018; 6(9):3025-3029
Gupta N, Arora M, Sharma R, Arora KS. Peripheral and central nervous system involvement in recently diagnosed cases of hypothyroidism: An electrophysiological study. Ann Med Health Sci Res 2016; 6:261-6.
Khedr EM, El-Toony LF, Tarkhan MN, and Abdella G. Peripheral and Central Nervous System Alterations in Hypothyroidism: Electrophysiological Findings. Neuro-psychobiology. 2000; 41(2): 88-94.
Gupta G, Sharma P, kumar P, Itagappa M, and Sharma R. correlation between thyroid stimulating hormone and body mass index in women with subclinical hypothyroidism. 2015 :Vol 8, Issue 4, 2015
Zhang J, Jiang R, Li L, Li P, Li X, Wang Z, et al. Serum thyrotropin is positively correlated with the metabolic syndrome components of obesity and dyslipidemia in chinese adolescents. Int J Endocrinol 2014;2014:289503
Paladugu S, Hanmayyagari BR, Kudugunti N, Reddy R, Sahay R, Ramesh J. Improvement in subclinical cognitive dysfunction with thyroxine therapy in hypothyroidism: A study from tertiary care center. Indian J Endocrinol Metab. 2015;196:829–33.
Jayanthi M, Vinodha R. Prolongation of VEP P100 latency in hypothyroidism. Int J Curr Res 2015;7:19645‑48
ProsolMW., and Ejma M. Assessment of Visual and Brainstem Auditory EvokedPotentials in Patients with Hashimoto’s Thyroiditis: Journal of Immunology Research, 2021, Article ID 3258942;1- 11. https://doi.org/10.1155/2021/3258942
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