Analysis of clinicolaboratory profile and outcome in COVID-19 positive pediatric patients

https://doi.org/10.53730/ijhs.v6nS3.6633

Authors

  • Darshana Gaira
  • Nutan Singh
  • Ruchi Bhatt
  • Vinita Rawat
  • Abhinav Bisht

Keywords:

COVID-19, clincolaboratory profile, pediatrics patients

Abstract

COVID-19 infection in children has important public health, social, and economic implications, and even though children may have considerably milder symptoms than individuals >18 years of age, those infected seem to have the same levels of circulating virus in their body and may be as infectious as adults. The objective is to study clincolaboratory profile and outcome in COVID-19 positive pediatrics patients. This hospital based prospective observational study was conducted in the department of Pediatrics , Government Medical College , Haldwani  Uttarakhand. COVID 19 Positive Pediatric patient from birth to 18 years from September 2020 to September 2021 were enrolled in the study. Referred patients were 1 in moderate, 3 in severe and 1 in MIS-C group. Expired patients mostly belong to severe category. 1 patient expired due to celphos poisoning and was diagnosed as covid-19 on routine sampling. In conclusion these laboratory findings and clinical features should raise strong suspicion of COVID-19 infection and severity and could be used as a useful predictor for planning treatment in children with moderate to severe illness.

Downloads

Download data is not yet available.

References

World Health Organization. Coronavirus disease (COVID-19): Situation Report - 169. Geneva: WHO; 2020.

Andrews M.A, Areekal B, Rajesh K.R, Krishnan J, Suryakala R, Krishnan B, et al. First confirmed case of COVID-19 infection in India: A case report. Indian J Med Res 2020; 151 : 490-2.

Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID 19) outbreak in China: Summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA 2020;323:1239 42

Zimmermann P, Curtis N. Coronavirus infections in children including COVID-19: An overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children. Pediatr Infect Dis J 2020; 39 : 355-68.

Tan W.J, Zhao X, Ma X.J, Wang W, Niu P, Xu W, et al. A novel coronavirus genome identified in a cluster of pneumonia cases - Wuhan, China 2019-2020. China CDC Wkly 2020; 2 : 61-2

Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). Available from: https://www. who.int/docs/default-source/coronaviruse/who-china-jointmission-on-covid-19-final-report.pdf, accessed on March 31, 2020

Zhang Y, Chen C, Zhu S, Shu C, Wang D, Song J, et al. Isolation of 2019-nCoV from a stool specimen of a laboratoryconfirmed case of the coronavirus disease 2019 (COVID-19). China CDC Wkly 2020; 2 : 123-4.

Zeng H, Xu C, Fan J, Tang Y, Deng Q, Zhang W, et al. Antibodies in infants born to mothers with COVID-19 pneumonia. JAMA 2020; 323 : 1848-9

Lauer S.A, Grantz K.H, Bi Q, Jones F.K, Zheng Q, Meredith H.R, et al. The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: Estimation and application. Ann Intern Med 2020; 172 : 577-82

Liu Y, Yan L.M, Wan L, Xiang T.X, Le A, Liu J.M, et al. Viral dynamics in mild and severe cases of COVID-19. Lancet Infect Dis 2020; 20 : 656-7.

Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020; S0140e6736(20):30211e30217.

Dong Y, Mo X, Hu Y, et al. (2020) Epidemiological Characteristics of 2143 Paediatric Patients With 2019 Coronavirus Disease in China. Pediatrics.

Moreton E. (2020) Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. World Health Organisation.

Rodriguez-Morales A.J, Cardona-Ospina J.A, Gutierrez-Ocampo E, Villamizar Pena R, Holguin-Rivera Y, Escalera-Antezana J.P, et al. Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis. (2020) 34:101623. doi: 10.1016/j.tmaid.2020.101623

Centers for Disease Control and Prevention. Resources for Emergency Health Professionals. Health Alert Netw 2020 https://emergency.cdc.gov/han/2020/ han00432.asp (accessed June 3.

Wolff D, Nee S, Hickey N.S, Marschollek M. Risk factors for Covid 19 severity and fatality: A structured literature review. Infection 2021;49:15 28.

Bansal N, Ghafur A. COVID 19 in oncology settings. Cancer Res Stat Treat 2020;3 Suppl S1:13 4.

Liang W, Guan W, Chen R, Wang W, Li J, Xu K, et al. Cancer patients in SARS CoV 2 infection: Anationwide analysis in China. Lancet Oncol 2020;21:335 7

Marlais M, Wlodkowski T, Vivar elli M et al. The severity of COVID 19 in children on immunosuppressive edication. The Lancet Child and Adolescent Health 2020; 4(7): E17-E18

World Health Organization . Laboratory testing for coronavirus disease 2019 (COVID-19) in suspected humancases. Interim guidance, 2 March, 2020. Available from: https://apps.who.int/iris/handle/10665/331329, accessed on May 12, 2020.

Sethuraman N, Jeremiah S.S, Ryo A. Interpreting diagnostic tests for SARS-CoV-2. JAMA 2020. doi: 10.1001/ jama.2020.8259.

Englund J.A, Kim Y.J, McIntosh K, Human Corona Virus including middle east respiratory syndrome coronavirus. In Cherry JD, Harrison GJ, Kalpan SL, Steinbach WJ, Htez PJ, editorsFeigin and Cherry Textbook of Pediatric Infectious Diseases 8th edition. Philadelphia:Elsevier 2019: p 1846-1854

Sehgal.P, Kumar.B, Sharma.M, Salameh A.A, Kumar.S, Asha.P (2022), Role of IoT In Transformation Of Marketing: A Quantitative Study Of Opportunities and Challenges, Webology, Vol. 18, no.3, pp 1-11

Kumar, S. (2022). A quest for sustainium (sustainability Premium): review of sustainable bonds. Academy of Accounting and Financial Studies Journal, Vol. 26, no.2, pp. 1-18

Dr. Ritika Malik, Dr. Aarushi Kataria and Dr. Naveen Nandal, Analysis of Digital Wallets for Sustainability: A Comparative Analysis between Retailers and Customers, International Journal of Management, 11(7), 2020, pp. 358-370.

McIntosh K, Perlman S. Coronaviruses including Severe Acute Respiratory Distress Syndrome and Middle East Respiratory Syndrome. In Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas and Bennett’s Principles and Practicces of Infectious Diseases, *th edn. Philadelphia Elsevier, 2015; pp1928-1936

A day by day breakdown of Coronavirus symptoms how the disease, COVID-19, goes bad to worse https://www.businessinsider.in/science/news/a-day-by-day-breakdown-of-coronavirus-symptoms-shows-how-the-disease-COVID-19-goes-to-bad-to -worse/ articleshow/7425-7460; Accessed on 25th May,2020

Published

27-04-2022

How to Cite

Gaira, D., Singh, N., Bhatt, R., Rawat, V. ., & Bisht, A. (2022). Analysis of clinicolaboratory profile and outcome in COVID-19 positive pediatric patients. International Journal of Health Sciences, 6(S3), 3821–3829. https://doi.org/10.53730/ijhs.v6nS3.6633

Issue

Section

Peer Review Articles

Most read articles by the same author(s)