Comparative analysis of effect of submucosal dexamethasone and methylprednisolone injection on post-operative sequelae after third molar surgery in a randomized double blind manner
Keywords:
pain control, third molar, dexamethasone, methylprednisoloneAbstract
Background: Postoperative oedema is a consequence of tissue injury during surgery and the raising of muscular attachments, and appears as a result of direct trauma to blood and lymph vessels. Postoperative pain is a common phenomenon after surgery, due to surgical trauma and the release of pain mediators. After surgical extraction of impacted lower third molars, the pain is most intense 3-5 hours following extraction, just after the cessation of local anesthesia. Several methods of controlling the immediate inflammatory response associated with the third molar surgery abound in the literature. Aim of the study: To compare the effect of submucosal dexamethasone and methylprednisolone injection on post-operative sequelae after third molar surgery in a randomized double blind manner. Materials and methods: 45 Subjects for the present study were selected and divided into 3 groups of 15 patients each (group I- submucosal dexamethasone, group II sub-mucosal methylprednisolone, group III – submucosal placebo, normal saline) from amongst the patients who reported to OPD, at random basis irrespective of side, age, caste, creed, gender and socioeconomic status. Study was carried out in those patients who required surgical removal of impacted mandibular 3rd molars.
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Alcantara, CEP, Falci, SGM, Ferreira FO, Santos, CRR & Pinheiro, MLP 2014, ‘Pre-emptive effect of dexamethasone and methylprednisolone on pain, swelling, and trismus after third molar surgery: a split-mouth randomized triple-blind clinical trial’, Int. J. Oral Maxillofac. Surg, 43, 93–98.
Grossi, GB, Maiorana C, Garramone, RA, Borgonovo, A, Beretta, M, Farronato, D & Santoro, F 2007, ‘Effect of submucosal injection of dexamethasone on postoperative discomfort after third molar surgery: a prospective study’, J Oral Maxillofac Surg 65, 2218-2226.
Markovic, A, Todorovic, LJ 2007, ‘Effectiveness of dexamethasone and low-power laser in minimizing oedema after third molar surgery: a clinical trial’, Int. J. Oral Maxillofac. Surg., 36, 226–229.
Markovic, AB, Todorovic, L & Montenegro 2006, ‘Postoperative analgesia after lower third molar surgery: contribution of the use of long-acting local anesthetics, low-power laser, and diclofenac’, Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102, E4-E8.
Ata, JA, Ata, FA, Oltra, DP & Peñarrocha, M 2011, ‘Corticosteroids use in controlling pain, swelling and trismus after lower third molar surgery’, J Clin Exp Dent. 3, 5, E469-75.
Garcia, AG, Sampedro, GF, Gandara, Rey, JG & Torreira, MG 1997, ‘Trismus and pain after removal of impacted lower third molars’, J Oral Maxillofac Surg 55, 223-1226.
Osunde, OD, Adebola, RA & Omeje, UK 2011, ‘Management of inflammatory complications in third molar surgery: a review of the literature’, African Health Sciences, 11, 3, 530 – 537.
Kocer, G, Yuce, E, Oncul AT, Dereci, O & Koskan, O, 2014, ‘Effect of the route of administration of methylprednisolone on oedema and trismus in impacted lower third molar surgery’, Int. J. Oral Maxillofac. Surg. 43, 639–643.
Troullos, ES, Hargreaves, KM, Butler, DP & Dionne, R 1990, ‘Comparison of non steroidal anti-inflammatory drugs ibuprofen and flurbiprofen, and with methylprednisolone for acute pain, swelling,and trismus’, J Oral Maxillofac Surg 48, 945-952.
Montgomery, MT, Hogg, JP, Roberts, DL & Redding, SW 1990, ‘The use of glucocorticosteroids to lessen the inflammatory sequelae following third molar surgery’, J Oral Maxillofac Surg 48,179-187.
Majid, OW 2011, ‘Submucosal dexamethasone injection improves quality of life measures after third molar surgery: a comparative study’, J Oral Maxillofac Surg 69, 2289-2297.
Gataa, IS & Nemat, AH 2009, ‘Evaluation of the effectiveness of two methods using methylprednisolone on post operative sequelae following lower third molar surgery’, Kufa Med.Journal, Vol.12, No2.
Landucci, AC, Wosny, LC, Uetanabaro, A, Moro, MR & Araujo 2016, ‘Efficacy of a single dose of low-level laser therapy in reducing pain, swelling, and trismus following third molar extraction surgery’, Int. J. Oral Maxillofac. Surg. 45, 392–398.
Graziani, F, D’aiuto, F, Arduino, PG, Tonelli M & Gabriele, M 2006, ‘Perioperative dexamethasone reduces post-surgical sequelae of wisdom tooth removal. A splitmouth randomized double-masked clinical trial’, Int. J. Oral Maxillofac. Surg. 35, 241–246.
Majid, OW, Mahmood, WK 2011, ‘Effect of submucosal and intramuscular dexamethasone on postoperative sequelae after third molar surgery: comparative study’, British Journal of Oral and Maxillofacial Surgery 49 647–652.
Ustun, Y, Erdogan O, Esen E, Karsli ED 2003, ‘Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery’, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 96, 535–539.
Esen, E, Tasar F, Akhan O 1999, ‘Determination of the anti-inflammatory effects of methylprednisolone on the sequelae of third molar surgery’, J Oral Maxillofac Surg, 57, 10, 1201-1206.
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