Synthesis, characterization and evaluation of the bacterial, antioxidant and anticancer activity of pyrimidine derivatives
Keywords:
heterocyclic sextants, pyrimidines, staphylococcus aureus, escherichia coli, antioxidant activity, breast cancerAbstract
In this paper, heterocyclic hexagonal rings were prepared for pyrimidine derivatives [I9-I16] by reacting a mole of gluconate derivatives with a mole of cyanoguanidine and using ethanol as a solvent. The accuracy of the compositions of the prepared compounds was confirmed by measuring the physical properties, including melting point, color, and molecular weight, as well as through spectroscopic measurements, including the infrared spectrum, the proton nuclear magnetic resonance spectrum, and the carbon-13 nuclear resonance spectrum. The biological activity of some prepared compounds and on two types of pathogenic bacteria, one of which is Gram-positive, which is Staphylococcus aureus, and one of which is Gram-negative, which is Escherichia coli, was studied. And the culture medium of the Multer Hinton Agar type was used, and chemical solutions were prepared for the two compounds (I9, I16) with concentrations (0,01, 0.001, 0.0001) mg /ml using a solvent dimethyl sulfoxide (DMSO). The sensitivity test of bacterial isolates used in the study was carried out by diffusion method, and the antibiotic Ciprofloxacin was used as a control sample. The effect of compound I15 on the removal of free radicals was also studied using DPPH root and at different concentrations.
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