Biochemical study of apelin hormone and its relationship to insulin and insulin resistance in the serum of obese patients in Nineveh Governorate
Keywords:
Obesity, Body mass index, Apelin, Insulin hormone and Insulin resistanceAbstract
The research included (117) cases collected from AL Salam Teaching Hospital in Mosul city, the cases were divided into two group, the first group included (93) patients with obesity either the second group included (24) healthy cases, both groups were divided into three subgroups: (20-35) (36-50) (51 and over) year, and included estimation of Apelin hormone, insulin hormone, insulin resistance, body mass index (BMI), sugar, creatinine, urea, phosphorus and unsaturated iron binding capacity (UIBC) in blood serum of the group of patients with obesity and comparing with control group, the results showed significant increase in alpine, insulin, insulin resistanse, urea, createnine, glogouse but significant decrease in uibc, bmi. The results also showed a positive correlation between Apelin and insulin, urea, creatinine, phosphorus and a negative correlation between Apelin and insulin resistance, glucose, UIBC, BMI.
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World Health Organization(WHO). 9 June 2021.Obesity and Overweight, https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
Matthias Helble and Azusa Sato, “WEALTHY BUT UNHEALTHY, Overweight and Obesity in Asia and the Pacific: Trends, Costs, and Policies for Better Health”, 2018, Asian Development Bank Institute(ADBI), Tokyo, Japan, p.3-4.
M. C. Tilinca, E. C. Barabas-Hajdu, G. T. Ferencz and E. Nemes-Nagy, Involvement of inflammatory cytokines in obesity and its complications, Romanian Journal of Laboratory Medicine, 2018, 26(3), 359-371.
F. Ekinci, D. Merder-Coşkun, B. Tuncel, D. Atila, H. Yıldız and A. Uzuner, Relationship between obesity and thyroid function in adults, Marmara Medical Journal, 2018; 31: 76-80.
S. Vandevijvere, C. C Chow, K. D Hall, E. Umalia & B. A Swinburn, Increased food energy supply as a major driver of the obesity epidemic: a global analysis, Bull World Health Organ 2015; 93:446–456. doi:http://dx.doi.org/10.2471/BLT.14.150565
E. Yildiz, M. Guldas, P. Ellergezen, A. G. Acar, O. Gurbuz, 2021, Obesity-associated Pathways of Anthocyanins, Food Sci. Technol, 41(1): 1-13.
Sant’Anna Jr M, Carvalhal RF, Oliveira FFB, Zin WA, Lopes AJ, Lugon JR, Guimarães FS, 2019, Respiratory mechanics of patients with morbid obesity, J Bras Pneumol. 2019;45(5):1-8. http://dx.doi.org/10.1590/1806-3713/e20180311
M. ALBashtawy, (2017) “Obesity and Body Image Perception among Adolescents”, EC Psychology and Psychiatry 4,(6), 216-217.
X Song, J Pitkaniemi, W Gao, RJ Heine, K Pyorala, S Soderberg, CDA Stehouwer, B Zethelius, J Tuomilehto, T Laatikainen, AG Tabak and Q Qiao, Relationship between body mass index and mortality among Europeans, European Journal of Clinical Nutrition, (2012) 66, 156–165.
Yarnell, J. (2009), Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet, 373, 1083-1096.
N. Sattar , I. B. McInnes, J. J.V. McMurray, 2020, Obesity Is a Risk Factor for SevereCOVID-19Infection,Circulation;142(1):4–6. DOI:10.1161/CIRCULATIONAHA.120.047659
Javaid F., Mehmood M.H. and Shaukat B., (2021), Hydroethanolic Extract of A. officinarum Hance Ameliorates Hypertension and Causes Diuresis in Obesogenic Feed-Fed Rat Model, Front. Pharmacol., 12:1-15. doi: 10.3389/fphar.2021.670433
K. M. Flegal, B. I. Graubard, D. F. Williamson, M. H. Gail, 2005, Excess Deaths Associated With Underweight, Overweight, and Obesity, JAMA;293:(15),1861-1867. Downloaded From: https://jamanetwork.com/ on 10/10/2021
O'Dowd, B. F.; Heiber, M.; Chan, A.; Heng, H. H. Q.; Tsui, L.-C.; Kennedy, J. L.; Shi, X.; Petronis, A.; George, S. R.; Nguyen, T., A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene 1993, 136, 355-360.
X.H. Yu, Z.B. Tang, L.J. Liu, H. Qian, S.L. Tang, D.W. Zhang, G.P. Tian, and C.K. Tang. Apelin and its receptor APJ in cardiovascular diseases. Clin. Chim. Acta. 428:1-8 (2014).
O’Carroll A.M., Lolait S.J., Harris L.E., Pope G.R., The apelin receptor APJ: Journey from an orphan to a multifaceted regulator of homeostasis. J Endocrinol. 2013;219:R13-35.
Narayanan, S.; Harris, D. L.; Maitra, R.; Runyon, S. P., Regulation of the apelinergic system and its potential in cardiovascular disease: Peptides and small molecules as tools for discovery. J. Med. Chem. 2015 ;58(20):7913-27. Article ASAP, DOI: 10.1021/acs.jmedchem.1025b00527.
Pitkin, S. L.; Maguire, J. J.; Bonner, T. I.; Davenport, A. P., International Union of Basic and Clinical Pharmacology. LXXIV. Apelin receptor nomenclature, distribution, pharmacology, and function. Pharmacol. Rev. 2010, 62, 331-342.
J. Roche, C. Ramé, M. Reverchon, N. Mellouk, A. Rak, P. Froment and J Dupont, Apelin (APLN) regulates progesterone secretion and oocyte maturation in bovine ovarian cells, Reproduction (2017) 153 589–603. DOI: 10.1530/REP-16-0677
Folino A, Montarolo PG, Samaja M, Rastaldo R. Effects of apelin on the cardiovascular system. Heart Fail Rev. 2015;20:505-18.
D. Cirakoglu, A. Cirakli, H. Erdem, E. Uzun, M. A. Celik, Variations in Apelin Expression Levels during Achilles Tendon Healing, Mid Blac Sea J Health Sci., 2021;7(1):57-63. DOI: 10.19127/mbsjohs.873010.
H. Nuru, N. Piaseu, R. Phuphaibu, U. Suthutvoravut, Predictors of Insulin Resistance in Indonesian Adolescents with Obesity, Pacific Rim Int J Nurs Res, 2017; 21(4) 280-290
W. T. Friedewald, R. I. Levy, and D. S. Fredrickson, “Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge,” Clin. Chem., vol. 18, no. 6, pp. 499–502, Jun. 1972, doi: 10.1093/clinchem/18.6.499.
A. A. ALhaboo and L. F. Bdaiwi, Evaluation the Role of Hepcidin in Women with Osteoporosis, Egypt. J. Chem. Vol. 64, No. 12, pp. 7183 - 7190 (2021).
A. A. Al-Fayyad, N. I. Al-Lehebe, Relation of Lipoxygenase Activity with Some Biochemical Parameters in Epilepsy Patients, Egypt. J. Chem. Vol. 64, No. 10, pp. 5619 - 5626 (2021).
Rahman, M.S.; Hossain, K.S.; Das, S.; Kundu, S.; Adegoke, E.O.; Rahman, M..A.; Hannan, M..A.; Uddin, M.J.; Pang, M.-G., Role of Insulin in Health and Disease: An Update. Int. J. Mol. Sci., 2021, 22,6403,1-19. https://doi.org/10.3390/ijms22126403
Y. T. Wondmkun, Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Dovepress, 2020:13, 3611–3616.
D. Ünal , A. Kara, S. Aksak, B. Z. Altunkaynak, S. Yıldırım, Insulin hormone: Mechanism and effects on the body and relationship with central nervous system, Dicle Medical Journal, 2012; 39 (2): 310-315. doi:10.5798/diclemedj.0921.2012.02.0149
E. Isganaitis, R. H. Lustig, Fast Food, Central Nervous System Insulin Resistance, and Obesity, Arterioscler Thromb Vasc Biol(ATVB), 2005;25:2451-2462. DOI: 10.1161/01.ATV.0000186208.06964.91
U. J. Jung and M. S. Choi, Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease, Int. J. Mol. Sci. 2014, 15, 6184-6223; doi:10.3390/ijms15046184
F. Imamura, R. Micha, J. H. Y. Wu, M. C. de Oliveira Otto, F.O. Otite, A. I. Abioye and D. Mozaffarian, Effects of Saturated Fat, Polyunsaturated Fat, Monounsaturated Fat, and Carbohydrate on Glucose-Insulin Homeostasis: A Systematic Review and Meta-analysis of Randomised Controlled Feeding Trials, PLoS Med,2016, 13(7):1-18.doi:10.1371/journal.pmed.1002087
C. B. Breneman and L. Tucker, Dietary fibre consumption and insulin resistance – the role of body fat and physical activity, British Journal of Nutrition (2013), 110, 375–383. doi:10.1017/S0007114512004953
H. Qu, Q. Li, A. R. Rentfro, S. P. Fisher-Hoch, J. B. McCormick, The Definition of Insulin Resistance Using HOMA-IR for Americans of Mexican Descent Using Machine Learning, PLoS ONE, 2011, 6(6): 1-4. e21041. doi:10.1371/journal.pone.0021041
D. Bhosle, A. Sayyed, A. Bhagat, H. Sheikh, V. Londhe, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) in the Diagnosis of Insulin Resistance and Prediabetes, JMSCR, 2016, 04(09), 12705-12710.
https://www.sciencedaily.com/releases/2009/03/090302115755.htm .
https://www.sciencedaily.com/releases/2009/03/090302115755.htm
Diabetes Care 2020;43:e15–e16 | https://doi.org/10.2337/dc19-1865
(Kleinz et al., 2005)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117999 /
Diabet).es Care 2020;43:e15–e16 | https://doi.org/10.2337/dc19-1865
(Castan-Laurell et al., 2008
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