Assessing the relationship of vitamin D and Glycosylated haemoglobin to establish better therapeutic guidelines in type 2 diabetes mellitus

Irfan Ahmad Khan; Shalini Chandra; Mohan Lal Kanojia; Iram Shaifali

doi:10.53730/ijhs.v6nS3.6888

Authors

Irfan Ahmad Khan Ph.D. Scholar, BIU, Assistant Professor Department of Pharmacology, Mayo Institute of Medical Sciences, Barabanki, Lucknow. Uttar Pradesh India
Shalini Chandra Professor & Head Department of Pharmacology, Rohilkhand Medical College & Hospital Bareilly, Uttar Pradesh, India
Mohan Lal Kanojia Professor Department of General Medicine, Mayo Institute of Medical Sciences, Barabanki, Uttar Pradesh, Lucknow, India
Iram Shaifali Professor Department of Pharmacology, Rohilkhand Medical College & Hospital Bareilly, Uttar Pradesh, India

Keywords:

25 hydroxyvitamin D, fasting plasma glucose, basal metabolic index

Abstract

Type 2 diabetes mellitus affects millions of people worldwide. it is a disease considered a major public health problem in India. Vitamin D deficiency was found to be more prevalent in India despite having sunny weather. Its deficiency was found to be correlated with glycosylated hemoglobin. We conducted this study in an effort to better understand the relationship between vitamin D and glycosylated hemoglobin in non-obese. A total of 119 type 2 diabetes patients were recruited in this cross-sectional study. Patient details and biochemical parameters were collected. Participants were divided into groups with vitamin D deficiency 25(OH) D <20 ng/ml and without vitamin D deficiency 25(OH) D >20 ng/mL, Further subgrouping was done into male and female-only groups. Next, the subjects were divided into male and female groups according to their 25(OH)D levels. The finding showed a significantly higher level of HbA1c (8.02±0.35%) in the vitamin D deficiency group compared to (7.32±0.41%) without vitamin D deficiency (p <.001). And it was also true for creatinine (0.94±0.14 vs. 0.82±0.17) (p<.001) HbA1c and fasting plasma glucose both were significant negatively correlated with vitamin D deficient group only (r = - 0.49, p <.001), (r = - 0.40, p = 0.001).

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