Comparative evaluation of various methods of diagnosis of malaria and assessment of hematological parameters in malarial infection: A three year prospective study in tertiary care hospital of western Odisha

Binod Kumar Sahu; Bikash Ranjan Panda; Shree Kumar Chinmayananda Mishra; Sanjukta Dixit

doi:10.53730/ijhs.v6nS2.6915

Authors

Binod Kumar Sahu Assistant Professor, Pathology, Vir Surendra Sai Institute Of Medical Sciences And Research (Vimsar), Burla
Bikash Ranjan Panda Assistant Professor, Pathology, Vir Surendra Sai Institute Of Medical Sciences And Research (Vimsar), Burla
Shree Kumar Chinmayananda Mishra
drskcmishra@gmail.com
Assistant Professor, Pathology, Prm Medical College, Baripada- 757107
Sanjukta Dixit Assistant Professor, Psychiatric Nursing, Kalinga Insitute Of Nuesing Science, Bhubaneswar

Keywords:

malaria, QBC, RDT, anemia, thrombocytopenia

Abstract

Background:Malaria remains a substantial health problem in many parts of world, especially in the tropical developing nations. Management of malaria requires early and accurate diagnosis. The aim of this study was to measure and compare the diagnostic accuracy of different methods of diagnosis of malaria and to study the limitations mostly due to low parasite density. We also evaluate the haematological changes in malaria patients.Material and methods: The study was conducted on blood samples of patients presenting with pyrexia, attending the various Departments of VSS Institute of Medical Science &Research,Burla, Sambalpur. Blood samples were subjected to thick and thin blood smear examination, QBC method and Rapid Diagnostic Tests (RDTs). Haematological parameters including haemoglobin, total leukocyte count, differential count and total platelet count of malaria positive cases were studied. Results: Out of 186 cases of fever, 105 patients were positive for malaria by thick peripheral blood smears. Plasmodium falciparum constitutes 86.66% whereas P. vivax and mixed infections constitute 8.57% and 4.77% respectively of total malaria . The sensitivity of QBC test approached 100% with parasite densities above 500/cu.mm.Antigen detection method was found to be highly sensitive (92.70%) for the diagnosis of P. falciparum infection.

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