Pseudomonas aeruginosa from intensive care units
Prevalence, clinical and antimicrobial profile
Keywords:
Pseudomonas aeruginosa, antimicrobial, infectionsAbstract
Infections caused by resistant organisms are increasing in hospitalised patients. Pseudomonas aeruginosa is one the important pathogen which is resistant to many antimicrobials and associated with infections in intensive care units with higher rates of morbidity and mortality. It can cause wide range of infection in ICU patients like, wound infections, septicaemia, urinary tract infection, cystitis, and rarely pneumonia. The study was carried out with an aim to study prevalence, clinical and antimicrobial profile of ICU infections caused by P. aeruginosa. Bacteriological study of total 589 clinical specimens from different ICU s was done. Prevalence of P. aeruginosa infection was 13.66 %. Age group 21- 40 and 41 to 60 was most affected (36.25 %). Maximum isolates were from medicine ICU (51.25 %) and from urine specimen (37.5 %). Piperacillin (48.75 %) and Amikacin (47.5 %) showed most susceptibility pattern. To conclude it is very important to have routine surveillance of ICU infections to prevent pan drug resistant Pseudomonas aeruginosa infection.
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Boucher HW, George H, Talbot J, et al. Bad bugs, No drugs: No ESKAPE! An update from the infectious diseases society of America. Clin Infect Dis. 2009;48(1):1e12.
Dereli N, Ozayar E, Degerli S, Sahin S, Koç F. Three-Year Evaluation of Nosocomial Infection Rates of the ICU. Braz J Anesthesiol. 2013;63(1):73-8.
Esposito S, Leone S. Antimicrobial treatment for intensive care unit (ICU) infections including the role of the infectious disease specialist. Int J Antimicrob Agents. 2007;29:494e500.
Moore LS, Freeman R, Gilchrist M, et al. Homogeneity of antimicrobial policy, yet heterogeneity of antimicrobial resistance: antimicrobial non-susceptibility among clinical isolates from primary, secondary and tertiary carevpatients in London. J Antimicrob Chemother. 2014;69(12):v3409e3422
Pachori P, Gothalwal R, Gandhi P. Emergence of antibiotic resistance Pseudomonas aeruginosa in intensive care unit; a critical review. Genes & diseases. 2019 Jun 1;6(2):109-19.
Oie S, Fukui Y, Yamamoto M, Masuda Y, Kamiya A. In vitro antimicrobial effects of aztreonam, colistin, and the 3-drug combination of aztreonam, ceftazidime and amikacin on metallo b-lactamase-producing Pseudomonas aeruginosa. BMC Infect Dis. 2009;9:123.
Collee JG, Miles RS, Watt B. Tests for identification of bacteria. In: Collee JG, Fraser AG, Marmion BP, Simmons A, Mackie, McCartney's, editors. Practical Medical Microbiology. 14th ed. Edinburgh: Churchill Livingstone; 1996. 131–150.
Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing; CLSI document M100-S30.2020
Gill JS, Arora S, Khanna SP, Kumar KH. Prevalence of multidrug-resistant, extensively drug-resistant, and pandrug-resistant Pseudomonas aeruginosa from a tertiary level intensive care unit. Journal of global infectious diseases. 2016 Oct;8(4): 155-159.
Loureiro MM, De Moraes BA, Mendonça VL, Quadra MR, Pinheiro GS, Asensi MD. Pseudomonas aeruginosa: study of antibiotic resistance and molecular typing in hospital infection cases in a neonatal intensive care unit from Rio de Janeiro City, Brazil. Memórias do Instituto Oswaldo Cruz. 2002; 97:387-94.
Javiya VA, Ghatak SB, Patel KR, Patel JA. Antibiotic susceptibility patterns of Pseudomonas aeruginosa at a tertiary care hospital in Gujarat, India. Indian journal of pharmacology. 2008 Oct;40(5):230-234
Peix, A., Ramírez-Bahena, M. H., & Velázquez, E. Historical evolution and current status of the taxonomy of genus Pseudomonas. Infection, Genetics and Evolution, 2009; 9(6), 1132-1147.
Moss, W. J., Beers, M. C., Johnson, E., Nichols, D. G., Perl, T. M., Dick, J. D., ... & Willoughby, R. E. Pilot study of antibiotic cycling in a pediatric intensive care unit. Critical care medicine, 2002; 30(8), 1877-1882.
Senthamarai S. Resistance pattern of Pseudomonas aeruginosa in a tertiary care hospital of Kanchipuram, Tamilnadu, India. Journal of clinical and diagnostic research: JCDR. 2014 May;8(5): DC30-DC32
Anupurba S, Battacharjee A, Garg A, Ranjansen M. The antimicrobial susceptibility of Psuedomonas aeruginosa isolated from wound infections. Indian J Dermatol. 2006; 51(4): 286-88.
OkonK O, Aguwe PC, Oladosu W,Balogun, Uba A, Antibiotic resistance patterns of Pseudomonas aeruginosa isolated from clinical specimens in a tertiary care hospital in Northeastern Nigeria. Journal of microbiology and antimicrobials. 2009, Vol 1(2); 019:026
Shah DA, Wasim S, Abdullah FE. Antibiotic resistance pattern of Pseudomonas aeruginosa isolated from urine samples of Urinary Tract Infections patients in Karachi, Pakistan. Pakistan journal of medical sciences. 2015 Mar;31(2):341-346
Sivanmaliappan TS, Sevanan M. Antimicrobial Susceptibility Patterns of Pseudomonas aeruginosa from Diabetes Patients with Foot Ulcers. International Journal of Microbiology. 2011 Nov 17; 2011:605195-
Ibukun A, Tochukwu N, Tolu O. Occurrence of ESBL and MBL in clinical isolates of Pseudomonas aeruginosa From Lagos, Nigeria. Journal of American Science. 2007; 3(4): 81-85.
Ayse Yüce, Nur Yapar, Oya Eren Kutsoylu. Evaluation of antibiotic resistance patterns of pseudomonas aeruginosa and Acinetobacter spp. strains isolated from intensive care patients between 2000-2002 and 2003-2006 periods in Dokuz Eylul University Hospital, Izmir Mikrobiyol Bul. 2009; 43(2):195-202
Mohanasundaram KM. The antimicrobial resistance pattern in the clinical isolates of Pseudomonas aeruginosa in a tertiary care hospital: 2008-2010(a 3-year study). Journal of Clinical and Diagnostic Research. 2011, Vol-5(3);491-94
Dwivedi M, Mishra A, Singh RK, Azim A, Baronia AK, Prasad KN. The nosocomial cross – transmission of Pseudomonas aeruginosabetween patients in a tertiary intensive care unit. Indian J Pathol Microbiol. 2009; 52(4): 509-13.
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