Anti - diabetic activity of aeschynanthus sikkimensis (clarke) stapf. extract in streptozotocin induced hyperglycemic rats

Abhimanyu  Nepal; Mainak Chakraborty; Sandipan Jana; Pallab Kanti Haldar

doi:10.53730/ijhs.v6nS1.7355

Authors

Abhimanyu Nepal Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, West Bengal, India
Mainak Chakraborty Department of Pharmaceutical Technology, NSHM Knowledge Campus Kolkata Group of Institutions, 124, B.L Saha Road, Kolkata-700053, India
Sandipan Jana Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, West Bengal, India
Pallab Kanti Haldar
pallab_haldar@rediffmail.com
Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, West Bengal, India

Keywords:

Streptozotocin (STZ), Aeschynanthus sikkimensis (Clarke) Stapf., phytol, glibenclamide

Abstract

Objective: The research was design to conduct anti-diabetic activity of methanol extract of Aeschynanthus sikkimensis (Clarke) Stapf. in streptozotocin induce hyperglycemic rats. Material and method: Streptozotocin 35mg/kg body weight was injected intraperitoneal to produce hyperglycemia rats which were pretreated with a high fat diet.72 hours after introduction of STZ, the hyperglycemic rats received MEAS at dose 200 and 400 mg/kg body weight for 28 days. Reference drug used was Glibenclamide (0.5 mg/kg, orally). During the 28 days treatment fasting blood glucose level were determined on every 7^th day. Serum and hepato renal biochemical parameters were estimated. Result: MEAS at the dose of 200 and 400mg/kg outstandingly (P <0.05) and dosage dependently reduce blood glucose levels towards normal as differentiate to STZ control group Serum and hepato renal biochemical parameter were altogether (P<0.05) restore towards the typical levels in MEAS sedated rats as differentiated to STZ control group. Conclusion: It may be concluded that the whole plant extract of Aeschynanthus sikkimensis (Clarke) Stapf which belong to the family Gesneriaceae showed encouraging hypoglycemic action in STZ induced diabetic rats.

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