Antidiabetic activities of  menthone on insulin resistant in 3T3-L1 adipocytes

M. Revathi; K. Padmalochana; C. Sankaranarayanan; S. Nalini; P. Ramya

doi:10.53730/ijhs.v6nS1.7360

Authors

M. Revathi Research scholar, Department of Biochemistry, Sri Akilandeswari Womens College,Vandavasi-604 408
K. Padmalochana
devnathyazhini@gmail.com
Department of Biochemistry, Sri AkilandeswariWomens College,Vandavasi--604 408
C. Sankaranarayanan Department of Biochemistry & Biotechnology, Annamalai University, Annamalai Nagar, Chidambaram- 608002
S. Nalini Department of Microbiology, Shree Ragavendra Arts and Science College, Keezhamoongiladi, Chidambaram-608102
P. Ramya Department of Microbiology, Shree Ragavendra Arts and Science College, Keezhamoongiladi, Chidambaram-608102

Keywords:

Antidiabetic, insulin resistant, 3T3-L1 adipocytes

Abstract

Background: Diabetes mellitus (DM) is a metabolic disorder characterised by chronic hyperglycaemia and metabolic consequences caused by insulin defects. Adipose tissue is an endocrine organ that influences glucose and lipid metabolism by releasing adipokines; adipose tissue is vital for the life of mammals. It represents the major source of fatty acid. Brown adipose tissue (BAT) and white adipose tissue (WAT) are the basic adipose tissue forms. They have different functions and cellular compositions and localization. They are essentially adversarial in terms of functionality. WAT is known to contain the most body fat; its involvement in the storage of excess dietary triglycerides. It is the source of free fatty aid used as energy substrates for the generation through oxidative phosphate of (ATP) high-energy bonds. During insulin resistance, the secretion of the hormone from the pancreatic islet cells cannot trigger glucose uptake in metabolic tissues, leading to elevated blood glucose and insulin levels. Menthone is cyclic monoterpenes and is reported to have several biological activities. This study, explores the potential antidiabetic effects invitro of menthone in the 3T3L1 adipocytes. Methods: The differentiation of 3T3-L1 preadipocytes into mature adipocytes were cultured and maintained.

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