The effect of sex hormones on progression of Leishmania donovani infection in liver and spleen of BALB/c mice
Keywords:
sex hormones, estradiol, testosterone, visceral leishmaniasis, Leishmania donovani, hepatosplenomegalyAbstract
Leishmania donovani invades and resides within tissue macrophages in the spleen, liver, and bone marrow leading to a histological change such as hepatosplenomegaly. In the present study we experimented the effect of gender and sex hormones on the progression of the visceral leishmaniasis disease in the liver and the spleen of BALB/c mice. The mice were divided into two groups, males and females, then male group was divided into three sub groups, first injected normal saline (control), the second injected with 107 promastigotes intraperitonially and the third injected with 107 promastigotes intraperitonially plus estradiol subcutaneously. Female group was divided into three groups, the first injected with normal saline, the second injected with 107 promastigotes and the third injected with 107 promastigotes intraperitonially plus testosterone subcutaneously. After six weeks, all animals were sacrificed and dissected then liver and spleen were removed, weighted and histological sections were made from them.
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