Comparison of proteolytic enzymes vs corticosteroids in preventing postoperative sequelae in mandibular third surgery: A systematic review

Vivek D. Menon; M. R. Muthusekhar

doi:10.53730/ijhs.v6nS3.7450

Authors

Vivek D. Menon Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai
M. R. Muthusekhar
Muthusekar@saveetha.com
Professor and Head of Department, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai

Keywords:

pain, inflammation, impaction, enzymes, steroids

Abstract

Third molar removal is the most frequently done procedure. Pain, swelling, trismus, alveolar osteitis are the most common postoperative complications. Few authors have used certain drugs like corticosteroids and proteolytic enzymes in order to reduce the postoperative complications.The aim of this systematic review is to evaluate in an evidence based way, the effectiveness of oral proteolytic enzymes and corticosteroids in controlling postoperative complications following mandibular third molar surgery. The objective of this systematic review is to compare the effectiveness of oral proteolytic enzymes and corticosteroids in preventing postoperative sequelae following mandibular third molar surgery. The Databases of PubMed, Cochrane and Google scholar were searched for the related topics along with a complimentary manual search of all oral surgery journals till December 2020. Four articles were selected based on the inclusion criteria. One among the four clinical trials comparing oral proteolytic enzymes and corticosteroids, they show significant differences proving post-operative swelling and trismus are less in patients receiving oral proteolytic enzymes compared to corticosteroids. In the other three trials patients receiving corticosteroids showed decreased post-operative swelling compared to oral proteolytic enzymes.

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