Estimation of C–reactive protein levels in COVID-19 patients: A laboratory based observational study

Priyanka M Mane; Makarand Mane; S. R. Patil

doi:10.53730/ijhs.v6nS2.7619

Authors

Priyanka M Mane Assistant Professor, Department of Microbiology, Krishna Institute of Medical Sciences Deemed to be University, Karad (Satara), India
Makarand Mane Associate Professor, Department of Medicine, Krishna Institute of Medical Sciences Deemed to be University, Karad (Satara), India
S. R. Patil
patil.drsatish@gmail.com
Professor, Department of Microbiology, Krishna Institute of Medical Sciences Deemed to be University, Karad (Satara), India

Keywords:

C-reactive protein, COVID-19, observational study

Abstract

COVID-19 is a health emergency due to its high infectiousness and high case fatality in critically ill patients. The pathological and physiological processes and diagnostic methods of COVID-19 are still in the exploratory stage. Clinical monitoring and appropriate treatment strategies are essential to improve case fatality. Aim of study was to detect the level of C- reactive protein in COVID-19 patients, prospective study was conducted in the Department of Microbiology, blood samples of the patient confirmed as COVID -19 positive patients were processed according to the standard laboratory Procedures. CRP was done by the commercially available kit (Rhelax CRP) based on the principle of latex agglutination. There were 13 males and 8 females within the young age group. They had CRP level 2.7524±3.69427 whereas 36 males and 7 females were in moderate grade of Covid 19 infection having CRP values 8.3140±23.01511 and at old age group had males 20 and females 14 with CRP values 6.5729±16.82460. CRP levels increased with disease progression. Conclusion- Higher levels of CRP indicate more severe disease course‐linked to lung injury and worse prognosis.

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References

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, Yu T. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The lancet. 2020 Feb 15;395(10223):507-13.

Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern. The lancet. 2020 Feb 15; 395(10223):470-3.

Young B, Gleeson M, Cripps AW. C-reactive protein: a critical review. Pathology. 1991 Jan 1;23(2):118-24.

Pepys MB, Hirschfield GM. C-reactive protein: a critical update. The Journal of clinical investigation. 2003 Jun 15;111(12):1805-12.

Lin C, Ding Y, Xie B, Sun Z, Li X, Chen Z, Niu M. Asymptomatic novel coronavirus pneumonia patient outside Wuhan: the value of CT images in the course of the disease. Clinical imaging. 2020 Jul 1; 63:7-9.

Tan C, Huang Y, Shi F, Tan K, Ma Q, Chen Y, Jiang X, Li X. C‐reactive protein correlates with computed tomographic findings and predicts severe COVID‐19 early. Journal of medical virology. 2020 Jul;92(7):856-62.

Tian W, Jiang W, Yao J, Nicholson CJ, Li RH, Sigurslid HH, Wooster L, Rotter JI, Guo X, Malhotra R. Predictors of mortality in hospitalized COVID‐19 patients: a systematic review and meta‐analysis. Journal of medical virology. 2020 Oct;92(10):1875-83.

Bassetti M, Vena A, Giacobbe DR. The novel Chinese coronavirus (2019‐nCoV) infections: Challenges for fighting the storm. European journal of clinical investigation. 2020 Mar; 50(3).

Xie J, Covassin N, Fan Z, Singh P, Gao W, Li G, Kara T, Somers VK. Association between hypoxemia and mortality in patients with COVID-19. InMayo Clinic Proceedings 2020 Jun 1 (Vol. 95, No. 6, pp. 1138-1147). Elsevier.

Xu X, Chen P, Wang J, Feng J, Zhou H, Li X, Zhong W, Hao P. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Science China Life Sciences. 2020 Mar; 63(3):457-60.

Bilgir O, Bilgir F, Calan M, Calan OG, Yuksel A. Comparison of pre-and post-levothyroxine high-sensitivity c-reactive protein and fetuin-a levels in subclinical hypothyroidism. Clinics. 2015; 70:97-101.

Li G, De Clercq E. Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nature reviews Drug discovery. 2020 Mar; 19(3):149-50.

Castell JV, Gómez-Lechón MJ, David M, Andus T, Geiger T, Trullenque R, Fabra R, Heinrich PC. Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes. FEBS letters. 1989 Jan 2;242(2):237-9.

Castell JV, David M, Klapproth J, Heinrich PC, Andus T, Geiger T, GÓMEZ-LECHÓN M, HIRANO T, KISHIMOTO T. Interleukin-6 is the major regulator of acute phase protein synthesis in rat and man. In Advances in immunopharmacology 1989 Jan 1 (pp. 191-201). Pergamon.

Sehgal PB. Interleukin-6: a regulator of plasma protein gene expression in hepatic and non-hepatic tissues. Molecular biology & medicine. 1990 Apr 1; 7(2):117-30.

Nishimoto N, Terao K, Mima T, Nakahara H, Takagi N, Kakehi T. Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti–IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease. Blood, The Journal of the American Society of Hematology. 2008 Nov 15;112(10):3959-64..

Yang ML, Wang CT, Yang SJ, Leu CH, Chen SH, Wu CL, Shiau AL. IL-6 ameliorates acute lung injury in influenza virus infection. Scientific reports. 2017 Mar 6;7(1):1-1..

Lauder SN, Jones E, Smart K, Bloom A, Williams AS, Hindley JP, Ondondo B, Taylor PR, Clement M, Fielding C, Godkin AJ. Interleukin‐6 limits influenza‐induced inflammation and protects against fatal lung pathology. European journal of immunology. 2013 Oct;43(10):2613-25.

Warusevitane A, Karunatilake D, Sim J, Smith C, Roffe C. Early diagnosis of pneumonia in severe stroke: clinical features and the diagnostic role of C-reactive protein. PloS one. 2016 Mar 3;11(3):e0150269.

Chalmers S, Khawaja A, Wieruszewski PM, Gajic O, Odeyemi Y. Diagnosis and treatment of acute pulmonary inflammation in critically ill patients: the role of inflammatory biomarkers. World journal of critical care medicine. 2019 Sep 11; 8(5):59.

Matsumoto H, Kasai T, Sato A, Ishiwata S, Yatsu S, Shitara J, Murata A, Kato T, Suda S, Matsue Y, Hiki M. Association between C-reactive protein levels at hospital admission and long-term mortality in patients with acute decompensated heart failure. Heart and vessels. 2019 Dec;34(12):1961-8.