Study on immunoexpression of beta catenin and Ki 67 in oral squamous cell carcinomas
Keywords:
β-catenin, Aberrant expression, oral squamous cell carcinomasAbstract
Cancer is a global health problem. It is the third most common cause of death.1 Among the malignant lesions of the oral cavity squamous cell carcinoma represents the most common cancer. It comprises about 90% of oral cancers.2 To elucidate the expression of immunohistochemical localization of β-catenin, To evaluate proliferative index (ki 67) in oral squamous cell cancers. To stusdy the correlation between β-catenin expression, ki 67 expression and tumor differentiation. Comparative case control study. The study was done in Department of Pathology and E.N.T in a tertiary care hospital. 1 year. patients with signs and symptoms of oral squamous cell carcinoma and investigated in a tertiary care hospital setting. A total of 104 (84 Cases and 20 Controls) were included in the study. Biopsy specimens received to pathology department where gross examination of the specimens was done. Aberrant expression of β-catenin in different histological grades is statistically significant. The p-value is .001361. Aberrant expression of β-catenin increased with increase in histological grade. It can be concluded that β-catenin is a significant factor in predicting the histological grade in patients with SCC.
Downloads
References
Wunsch-filho v. The epidemiology of oral pharynx cancer in Brazil. Oral Onco 2002;38:737-46.
Gervasio OL, Dutra RA, Tartaglia SM, et al. Oral squamous cell carcinoma : a retrospective study of 740 cases in a Brazilian population. Braz Dent J 2001:12:57- 61.
Gupta PC, Warnakulasuriya S. Global epidemiology of areca nut usage. Addict Biol 2002;7:77-83.
Warnakulasuriya S. Causes of oral cancer-an appraisal of controversies.brdent J 2009; 207:471-5.
Gupta PC, Ray CS, Murti PR, Sinha DN. Rising incidence of oral cancer in Ahmedabad city. Indian J Cancer. 2014;51 Suppl 1:S67-72. Doi:10.4103/0019- 509X.147476.
Kaur J, Sawhney M, dattagupta S, Shukla NK, Srivastava A, Walfish PG, et al.
Clinical Significance of Altered Expression of β-catenin and E-Cadherin in Oral Dysplasia and Cancer: Potential Link with ALCAM Expression PLOS ONE 2013;8(6):e67361:1-12.
Ebrahimi M, Boldrup L, Wahlin YB, Coates PJ, Nylander K. Decreased expression of p63 related proteins β-catenin, E-cadherin and EGFR in oral lichen planus. Oral Oncology 2008;44:634-38.
Barth A. I., Nahke I. S., Nelson W. J. Cadherins, catenins, and APC protein: interplay between cytoskeletal complexes and signaling pathways. Curr. Opin. Cell Biol.1997, 9: 683-690.
Behrens J., von Kries J. P., Kuhl M., Bruhn L., Wedlich D., Grosschedl R., Birchmeier W. Functional interaction of β-catenin with the transcription factor LEF- 1. Nature (Lond.)1996, 382: 638-642.
Fillies t, woltering m,brandt b,van diest jp werkemeister r,joos u, buerger H.Cell Cycle regulatiog proteins P21 and P27 in prognosis of oral squamous cell carcinomas. Oncol Rep 2007:17:355-359.
De Moraes M, Monteiro Maia CAD, Freitas RDA. Cell proliferation markers in oral squamous cell carcinoma. J Mol Biomark Diagn. 2012;1(S2):930-935.
Cai zhi-gang,shi xiao-jian,wei ming-jie,wang cun-yu,yu gang-yan:β-catenin expression pattern in primary oral squamous cell carcinoma.china med J 2008;121(19):1866-1870.
Fernanda ferreira lopes,marcia cristina dacosta Miguel, Antonio Luiz Amaral Pereira, Maria Carmen Fontoura da Cruz, Roseana de Almeida Freitas, Leao Pereira Pinto, Leila Batista de Souza.Annals of diagnostic pathology13(2009) 22- 29.
Xia Yun1, Lihong Wang2,4, Lei Cao3, Norihiko Okada2 And Yoshio Miki1. Immunohistochemical study of β-catenin and functionally related molecular markers in tongue squamous cell carcinoma and its correlation with cellular proliferation. Oncology letters 2010:1: 437-443.
Partheeban Balasundaram,Manoj Kumar Singh,Amit Kumar Dinda,Alok Thakar,Rajni Yadav.Study of β-catenin ,E-Cadherin and vimentin in oral squamous cell squamous with and without lymphnode metastases.Diagnostic pathology 2014,9:145.
Lankesh B. Laxmidevi1), Punnya V. Angadi2), Rekha K. Pillai3) and Chethana Chandreshekar4). Aberrant β -catenin expression in the histologic differentiation of oral squamous cell carcinoma and verrucous carcinoma: an immunohistochemical study. Journal of Oral Science, Vol. 52, No. 4, 633-640, 2010.
Monica C. Assessment of proliferative potential of tumor cells using ki-67 expression and morphometrical analysis for prognostication of oral squamous cell carcinomas. 2015;4(4):820-826.
Birajdar SS, Radhika MB, Paremala K, Sudhakara M, Soumya M, Gadivan M. Expression of Ki-67 in normal oral epithelium , leukoplakic oral epithelium and oral squamous cell carcinoma. 2017;18(2):169-176.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.